| [伍素瑩] 期刊論文 |
2009-07-23 |
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity |
- |
 |
| [伍素瑩] 期刊論文 |
2006-08-24 |
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease |
- |
|
| [伍素瑩] 期刊論文 |
2006-06-15 |
Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies |
- |
|
| [伍素瑩] 期刊論文 |
2006-05-04 |
Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities |
- |
|
| [其他] 期刊論文 |
2009-04-24 |
Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway |
- |
|
| [喻秋華] 期刊論文 |
2019-10-08 |
Identification of two novel small compounds that inhibit liver cancer formation in zebrafish and analysis of their conjugation to nanodiamonds to further reduce toxicity |
- |
|
| [夏克山] 期刊論文 |
2015-02 |
Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors |
- |
|
| [張俊彥] 期刊論文 |
2024-05-09 |
Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function |
- |
|
| [張俊彥] 期刊論文 |
2019-12 |
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry |
- |
|
| [張俊彥] 期刊論文 |
2011-09 |
Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents |
- |
|
| [張俊彥] 期刊論文 |
2011-08 |
BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells |
- |
|
| [張俊彥] 期刊論文 |
2010-09 |
Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes |
- |
|
| [張俊彥] 期刊論文 |
2010-03-11 |
5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors |
- |
|
| [張俊彥] 期刊論文 |
2009-07-03 |
Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers |
- |
|
| [張俊彥] 期刊論文 |
2009-04-17 |
Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents |
- |
|
| [張俊彥] 期刊論文 |
2009-04 |
Aurora kinase inhibitors in preclinical and clinical testing |
- |
|
| [張俊彥] 期刊論文 |
2008-07-24 |
Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors |
- |
|
| [張俊彥] 期刊論文 |
2008-02 |
A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells |
- |
|
| [張俊彥] 期刊論文 |
2007-09-06 |
4-and 5-aroylindoles as novel classes of potent antitubulin agents |
- |
|
| [張俊彥] 期刊論文 |
2007-07-31 |
Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil |
- |
|
| [張俊彥] 期刊論文 |
2006-11-16 |
7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents |
- |
|
| [張俊彥] 期刊論文 |
2004-07-15 |
A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells |
- |
|
| [張俊彥] 期刊論文 |
2004-07-01 |
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo |
- |
|
| [張俊彥] 期刊論文 |
2003-03-10 |
Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents (vol 13, pg 101, 2003) |
- |
|
| [張俊彥] 期刊論文 |
2003-01-06 |
Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents |
- |
|
| [張文祥] 期刊論文 |
2010-06 |
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis |
- |
|
| [徐祖安] 專利 |
2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
- |
|
| [徐祖安] 專利 |
2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
- |
|
| [徐祖安] 專利 |
2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
- |
|
| [徐祖安] 專利 |
2009-06-09 |
Treatment of coronavirus infection |
- |
|
| [徐祖安] 專利 |
2008-02-11 |
一種抗病毒之醫藥組合物 |
- |
|
| [徐祖安] 會議論文/會議摘要 |
2014-03 |
DBPR112, a potent and selective EGFR kinase inhibitor in preclinical study |
- |
|
| [徐祖安] 會議論文/會議摘要 |
2011-03 |
Potent EGFR tyrosine kinase inhibitors as anticancer agents |
- |
|
| [徐祖安] 期刊論文 |
2015-01 |
Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity |
- |
|
| [徐祖安] 期刊論文 |
2014-05 |
Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014) |
- |
|
| [徐祖安] 期刊論文 |
2013-09-22 |
A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411] |
- |
|
| [徐祖安] 期刊論文 |
2013-05 |
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors |
- |
|
| [徐祖安] 期刊論文 |
2013-04-29 |
A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment |
- |
|
| [徐祖安] 期刊論文 |
2013-02-20 |
Parallel screening of Wild-Type and drug-resistant targets for anti-resistance neuraminidase inhibitors |
- |
|
| [徐祖安] 期刊論文 |
2012-02 |
Identification of BPR3P0128 as an Inhibitor of cap-snatching activities of influenza virus |
- |
|
| [徐祖安] 期刊論文 |
2012-01 |
A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors |
- |
|
| [徐祖安] 期刊論文 |
2010-01 |
BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses |
- |
|
| [徐祖安] 期刊論文 |
2009-02 |
Aurintricarboxylic acid inhibits influenza virus neuraminidase |
- |
|
| [徐祖安] 期刊論文 |
2008-05 |
Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana |
- |
|
| [徐祖安] 期刊論文 |
2005 |
Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3 '- digallate (TF3) |
- |
|
| [徐祖安] 期刊論文 |
2004-09-10 |
Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV |
- |
|
| [徐祖安] 期刊論文 |
2004-07 |
Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide |
- |
|
| [李秀珠] 會議論文/會議摘要 |
2004-09 |
Drug design of BPR0L075 as an anticancer agent |
- |
|
| [李秀珠] 會議論文/會議摘要 |
2004-07 |
Drug design for BPR0L075 as an anticancer agent |
- |
|
| [李秀珠] 會議論文/會議摘要 |
2003 |
The synthetic 1-aroylindoles and 3-aroylindoles derivatives, combretastatin A-4 analogues, as a novel class of potent anticancer agents |
- |
|
| [林峯輝] 期刊論文 |
2024-06-24 |
Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease |
- |
|
| [紀雅惠] 期刊論文 |
2018-05-10 |
Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition |
- |
|
| [葉修華] 期刊論文 |
2024-10-29 |
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration |
- |
|
| [葉修華] 期刊論文 |
2023-10-05 |
A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects |
- |
|
| [葉燈光] 會議論文/會議摘要 |
2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer |
- |
|
| [葉燈光] 會議論文/會議摘要 |
2017-04 |
Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation |
- |
|
| [葉燈光] 會議論文/會議摘要 |
2013-11 |
A development drug candidate targeting EGFR kinase for lung cancer: DBPR112 |
- |
|
| [葉燈光] 期刊論文 |
2007-07 |
Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes |
- |
|
| [蔣維棠] 專利 |
2012-04-21 |
吡咯啉啶化合物 |
- |
|
| [蔣維棠] 專利 |
2012-01-17 |
Pyrrolidine compounds |
- |
|
| [蔣維棠] 專利 |
2010-10-06 |
吡咯烷化合物 |
- |
|
| [蔣維棠] 專利 |
2010-03-30 |
Pyrrolidine compounds |
- |
|
| [蔣維棠] 專利 |
2008-09-16 |
Pyrrolidine compounds |
- |
|
| [蔣維棠] 專利 |
2008-07-21 |
吡咯啉啶化合物 |
- |
|
| [蔣維棠] 專利 |
2008-07-01 |
Pyrrolidine compounds |
- |
|
| [蔣維棠] 期刊論文 |
2007-03-01 |
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes |
- |
|
| [蔣維棠] 期刊論文 |
2006-06-15 |
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors |
- |
|
| [蔣維棠] 期刊論文 |
2006-01-12 |
2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV |
- |
|
| [謝興邦] 專利 |
2015-07-31 |
作為極光激酶抑制劑的稠合雙環嘧啶化合物 |
- |
|
| [謝興邦] 專利 |
2015-07-22 |
作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 |
- |
|
| [謝興邦] 專利 |
2015-04-14 |
Fused multicyclic compounds as protein kinase inhibitors |
- |
|
| [謝興邦] 專利 |
2014-10-29 |
作為極光激酶抑制劑的稠合雙環嘧啶化合物 |
- |
|
| [謝興邦] 專利 |
2014-10-21 |
化合物於製造治療病毒感染的藥物之用途 |
- |
|
| [謝興邦] 專利 |
2014-04-29 |
Quinoline compounds and their use for treating viral infection |
- |
|
| [謝興邦] 專利 |
2014-03-20 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
- |
|
| [謝興邦] 專利 |
2013-11-21 |
治療癌症的醫藥組成物 |
- |
|
| [謝興邦] 專利 |
2013-10-01 |
喹啉化合物及包含其之治療病毒感染之醫藥組成物 |
- |
|
| [謝興邦] 專利 |
2013-08-21 |
Fused multicyclic compounds as protein kinase inhibitors |
- |
|
| [謝興邦] 專利 |
2013-08-13 |
Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors |
- |
|
| [謝興邦] 專利 |
2013-07-01 |
做為蛋白質激酶抑制劑之稠合多環化合物 |
- |
|
| [謝興邦] 專利 |
2013-02-11 |
作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物 |
- |
|
| [謝興邦] 專利 |
2012-05-11 |
作為極光激酶抑制劑之稠合雙環嘧啶化合物 |
- |
|
| [謝興邦] 專利 |
2012-03-20 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
- |
|
| [謝興邦] 專利 |
2012-03-06 |
Indole compounds |
- |
|
| [謝興邦] 專利 |
2011-11-15 |
Coumarin compounds and their use for treating cancer |
- |
|
| [謝興邦] 專利 |
2011-07-11 |
抑制C型肝炎病毒感染之倍半帖內酯類化合物及其醫藥組成物 |
- |
|
| [謝興邦] 專利 |
2011-04-06 |
Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis related disorders |
- |
|
| [謝興邦] 專利 |
2010-12-01 |
吲哚化合物 |
- |
|
| [謝興邦] 專利 |
2010-12-01 |
抗肿瘤化合物 |
- |
|
| [謝興邦] 專利 |
2009-12-15 |
Indole compounds |
- |
|
| [謝興邦] 專利 |
2009-12-01 |
芳香羰吲哚化合物 |
- |
|
| [謝興邦] 專利 |
2009-05-05 |
Indole compounds |
- |
|
| [謝興邦] 專利 |
2008-12-11 |
吲哚化合物 |
- |
|
| [謝興邦] 專利 |
2008-11-25 |
Anti-tumor compounds |
- |
|
| [謝興邦] 專利 |
2008-11-11 |
Indole compounds |
- |
|
| [謝興邦] 專利 |
2008-05-01 |
抗腫瘤化合物 |
- |
|
| [謝興邦] 專利 |
2005-08-23 |
Indole compounds |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2023-10 |
Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2019-10 |
The molecular mechanisms of EpCAM in regulating tumor progression and development of anti-EpCAM antibodies for colon cancer diagnosis and therapy |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2018-07 |
Clinical candidate DBPR112: A novel epidermal growth factor receptor inhibitor as a promising treatment for non-small cell lung cancer |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2017-04 |
Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2017-04 |
One-pot tandem oxidative dearomatization/ 4+3 cycloaddition: Masked o-benzoquinone with diaza-oxyallyl cation |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2015-08 |
BPR2P001S0, a Coumarin derivative, induced cell cycle arrest in A549 through inhibiting PDPK1 activity |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2015-08 |
Optimization of furanopyrimidine-based kinase inhibitors: Identification of a BTK kinase inhibitor for the treatment of B cell lymphoma |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2015-08 |
Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2014-11 |
Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2014-10 |
Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2014-10 |
Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2014-03 |
Efficient virtual screening using ligand efficiency based approach |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-11 |
Peptide-mediated liposomal doxorubicin enhances drug delivery efficiency and therapeutic efficacy in lung cancer animal models |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-04-07 |
BPR000K, a novel Aurora kinase inhibitor |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-04-07 |
Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-04-07 |
3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-04-07 |
Development drug candidate targeting EGFR kinase: DBPR112 |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2013-04 |
Design and synthesis of Aurora kinase inhibitors as anticancer agents |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2012-03-25 |
Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2011-09-23 |
BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2011-04 |
Antivascular activities of novel tubulin binding agent BPR0L075 |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2011-03-27 |
Design and synthesis of potent Aurora kinase inhibitors |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2011-03 |
SAR studies of quinoline derivatives as novel anti-influenza agents |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2010-08 |
Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2009-09 |
Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2009-05 |
Down-regulation of survivin enhances sensitivity to BPROL075 in human cancer cells via caspase-independent mechanisms |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2009-03 |
Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2007-07 |
Anti-influenza drug discovery |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2007-07 |
From bench to drug candidate: Design and synthesis of 5,6-fused heteroaromatics as anticancer agents |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2006-09 |
MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2005-03 |
Promazine analogues as potential anti SARS-CoV drugs |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2005-03 |
Design, synthesis and sar of indole-based PPAR agonists |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2005-03 |
Design and structure-activity relationships of novel indole-based PPAR agonists as antidiabetic agents |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2004-08-22 |
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents |
- |
|
| [謝興邦] 會議論文/會議摘要 |
2002-08 |
Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents |
- |
|
| [謝興邦] 期刊論文 |
2024-06-24 |
Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment |
- |
|
| [謝興邦] 期刊論文 |
2023-11-03 |
Influence of ring strain on the formation of rearrangement vs cyclization isotwistane products in the acyl radical reaction of bicyclo[2.2.2]octanone |
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| [謝興邦] 期刊論文 |
2023-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer |
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| [謝興邦] 期刊論文 |
2022-09-12 |
A critical overview of current progress for COVID-19: Development of vaccines, antiviral drugs, and therapeutic antibodies |
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| [謝興邦] 期刊論文 |
2022-08-09 |
Recent advances in total synthesis of natural products by masked ortho-benzoquinones |
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| [謝興邦] 期刊論文 |
2022-05-09 |
Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer |
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| [謝興邦] 期刊論文 |
2022-04-06 |
Identification of entry inhibitors against delta and omicron variants of SARS-CoV-2 |
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| [謝興邦] 期刊論文 |
2021-11-15 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization |
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| [謝興邦] 期刊論文 |
2021-10-14 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model |
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| [謝興邦] 期刊論文 |
2021-04-16 |
Development of a robust scale-up synthetic route for BPR1K871: A clinical candidate for the treatment of acute myeloid leukemia and solid tumors |
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| [謝興邦] 期刊論文 |
2021-02-22 |
Mimicking H3 substrate arginine in the design of G9a lysine methyltransferase inhibitors for cancer therapy: A computational study for structure-based drug design |
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| [謝興邦] 期刊論文 |
2021-01-31 |
Briarenols W-Z: Chlorine-containing polyoxygenated briaranes from octocoral briareum stechei (Kükenthal, 1908) |
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| [謝興邦] 期刊論文 |
2021-01-15 |
One-pot synthesis of dibenzo[b,f]oxepines and total synthesis of bauhinoxepin C |
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| [謝興邦] 期刊論文 |
2021-01 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors |
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| [謝興邦] 期刊論文 |
2020-12-10 |
Tumor-agnostic inhibitors in oncology: A new phase for precision medicine |
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| [謝興邦] 期刊論文 |
2020-08 |
Design of a potent anticancer lead inspired by natural products from traditional Indian medicine |
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| [謝興邦] 期刊論文 |
2020-07 |
Design of drug-like hepsin inhibitors against prostate cancer and kidney stones |
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|
| [謝興邦] 期刊論文 |
2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors |
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|
| [謝興邦] 期刊論文 |
2020-03-01 |
A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis |
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|
| [謝興邦] 期刊論文 |
2020-01 |
Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening |
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|
| [謝興邦] 期刊論文 |
2019-11-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer |
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|
| [謝興邦] 期刊論文 |
2019-07-03 |
Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: A molecular dynamics study |
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|
| [謝興邦] 期刊論文 |
2019-07 |
Dual Kit/Aur inhibitors as chemosensitizing agents for the treatment of melanoma: Design, synthesis, docking studies and functional investigation |
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|
| [謝興邦] 期刊論文 |
2019-05-29 |
Insights for the design of protein lysine methyltransferase G9a inhibitors |
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|
| [謝興邦] 期刊論文 |
2018-11 |
Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D |
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|
| [謝興邦] 期刊論文 |
2017-08-11 |
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer |
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|
| [謝興邦] 期刊論文 |
2017-07 |
Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors |
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|
| [謝興邦] 期刊論文 |
2016-12 |
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation |
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|
| [謝興邦] 期刊論文 |
2016-11-29 |
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design |
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|
| [謝興邦] 期刊論文 |
2016-07 |
Therapeutic polymeric nanoparticles and the methods of making and using thereof: A patent evaluation of WO2015036792 |
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|
| [謝興邦] 期刊論文 |
2016-03 |
Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target survivin |
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|
| [謝興邦] 期刊論文 |
2015-06-29 |
Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification |
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| [謝興邦] 期刊論文 |
2014-12 |
BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71 |
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|
| [謝興邦] 期刊論文 |
2014-10 |
Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer |
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|
| [謝興邦] 期刊論文 |
2014-08 |
CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors |
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|
| [謝興邦] 期刊論文 |
2014-08 |
Ligand efficiency based approach for efficient virtual screening of compound libraries |
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|
| [謝興邦] 期刊論文 |
2014-07 |
Anaplastic lymphoma kinase (ALK) inhibitors: A review of design and discovery |
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| [謝興邦] 期刊論文 |
2014-05 |
Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach |
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| [謝興邦] 期刊論文 |
2013-07-25 |
Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway |
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|
| [謝興邦] 期刊論文 |
2013-06-28 |
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor |
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| [謝興邦] 期刊論文 |
2013-06 |
An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells |
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| [謝興邦] 期刊論文 |
2013-05 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules |
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| [謝興邦] 期刊論文 |
2013-01 |
3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor |
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|
| [謝興邦] 期刊論文 |
2013-01 |
Substituent effects on the photorearrangements of unsymmetrically substituted diazinobarrelenes |
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|
| [謝興邦] 期刊論文 |
2012-12 |
An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold |
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|
| [謝興邦] 期刊論文 |
2012-09 |
Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization |
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|
| [謝興邦] 期刊論文 |
2012-08-24 |
Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts |
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|
| [謝興邦] 期刊論文 |
2011-09 |
Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway |
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|
| [謝興邦] 期刊論文 |
2011-06 |
Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10) |
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|
| [謝興邦] 期刊論文 |
2011-04-28 |
Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents |
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|
| [謝興邦] 期刊論文 |
2010-06-15 |
Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification |
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|
| [謝興邦] 期刊論文 |
2010-02-25 |
Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives |
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|
| [謝興邦] 期刊論文 |
2010-02-01 |
Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor |
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|
| [謝興邦] 期刊論文 |
2010-02 |
Comparative molecular field analysis of anti-tubulin agents with indole ring binding at the colchicine binding site |
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|
| [謝興邦] 期刊論文 |
2009-08-13 |
Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach |
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|
| [謝興邦] 期刊論文 |
2009-04-23 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists |
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|
| [謝興邦] 期刊論文 |
2009-03 |
Advances in Aurora kinase inhibitor patents |
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|
| [謝興邦] 期刊論文 |
2009-02-26 |
Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity |
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|
| [謝興邦] 期刊論文 |
2008-12-25 |
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents |
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|
| [謝興邦] 期刊論文 |
2008-07 |
Anti-HSV activity of digitoxin and its possible mechanisms |
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|
| [謝興邦] 期刊論文 |
2008-03-13 |
Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors |
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|
| [謝興邦] 期刊論文 |
2008-03-10 |
Reactions of 2-hydroxybenzophenones with Corey-Chaykovsky reagent |
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|
| [謝興邦] 期刊論文 |
2008-03-01 |
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold |
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|
| [謝興邦] 期刊論文 |
2008-02-07 |
First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol |
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|
| [謝興邦] 期刊論文 |
2007-12 |
Strategies of development of antiviral agents directed against influenza virus replication |
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|
| [謝興邦] 期刊論文 |
2007-02-01 |
Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study |
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|
| [謝興邦] 期刊論文 |
2006-10-19 |
Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists |
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|
| [謝興邦] 期刊論文 |
2006-10 |
Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents |
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|
| [謝興邦] 期刊論文 |
2006-07 |
Antiviral drug discovery against SARS-CoV |
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|
| [謝興邦] 期刊論文 |
2006-05 |
Antitubulin agents for the treatment of cancer - a medicinal chemistry update |
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|
| [謝興邦] 期刊論文 |
2006-02-09 |
Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies |
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|
| [謝興邦] 期刊論文 |
2006-01-01 |
Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system |
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|
| [謝興邦] 期刊論文 |
2005-12-29 |
Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities |
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|
| [謝興邦] 期刊論文 |
2005-05 |
Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells - Role of NF-kappa B |
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|
| [謝興邦] 期刊論文 |
2005-05 |
Pharmaceutical design of antimitotic agents based on combretastatins |
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|
| [謝興邦] 期刊論文 |
2004-08-12 |
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents |
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|
| [謝興邦] 期刊論文 |
2004-05-20 |
Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents |
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|
| [謝興邦] 期刊論文 |
2003-12-01 |
Substituent effects on di-pi-methane and aza-di-pi-methane rearrangements of dibenzo[f,h]quinoxalinobarrelenes |
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|
| [謝興邦] 期刊論文 |
2002-06-06 |
Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents |
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|
| [賴基銘(2004-2008)] 期刊論文 |
2007-02-08 |
Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells |
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|
| [趙宇生(2002-2013)] 專利 |
2009-01-22 |
Pyrrolidine compounds |
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|
| [趙宇生(2002-2013)] 期刊論文 |
2010-10-28 |
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency |
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|
| [趙宇生(2002-2013)] 期刊論文 |
2010-10 |
Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists |
- |
|
| [趙宇生(2002-2013)] 期刊論文 |
2010-07 |
Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 |
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|
| [趙宇生(2002-2013)] 期刊論文 |
2010-02-23 |
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity |
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|
| [郭靜娟] 會議論文/會議摘要 |
2018-07 |
Blockage of EGFR signaling repurposes tumor metabolism through suppression of glycolysis and Kreb cycle in head and neck cancer |
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|
| [鄒倫] 期刊論文 |
2021-04-13 |
Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908) |
- |
|
| [陳怡榮] 期刊論文 |
2008-06-01 |
A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors |
- |
|
| [陳新(2002-2015)] 期刊論文 |
2008-04-15 |
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus |
- |
|
| [陳炯東] 會議論文/會議摘要 |
2018-01 |
Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer |
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|
| [陳炯東] 會議論文/會議摘要 |
2015-08 |
Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia |
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|
| [陳炯東] 期刊論文 |
2006-12 |
Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats |
- |
|
| [陳立宗] 期刊論文 |
2011-03-07 |
2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors |
- |
|
| [陳立宗] 期刊論文 |
2003-06-15 |
Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent |
- |
|
| [顏婉菁] 期刊論文 |
2022-01-21 |
Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma |
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|
| [黃明熙] 期刊論文 |
2021-07-16 |
Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens |
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