國家衛生研究院 NHRI:作者相關文件

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"Shih, C"的相關文件

類別	日期	題名	關聯
[翁紹華] 期刊論文	2014-09	Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists	-
[翁紹華] 期刊論文	2017-01	Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists	-
[翁紹華] 期刊論文	2022-12-05	Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation	-
[翁紹華] 期刊論文	2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	-
[陳炯東] 期刊論文	2020-10-08	Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery	-
[翁紹華] 期刊論文	2019-04-01	The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone	-
[紀雅惠] 期刊論文	2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	-
[翁紹華] 期刊論文	2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	-
[翁紹華] 期刊論文	2014-08	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors	-
[葉修華] 期刊論文	2024-10-29	DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration	-
[葉修華] 期刊論文	2024-07-17	Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	-
[翁紹華] 期刊論文	2022-11	Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone	-
[紀雅惠] 期刊論文	2021-05-19	Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins	-
[伍素瑩] 期刊論文	2020-02-10	Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors	-
[葉修華] 期刊論文	2020-04	BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine	-
[鄒倫] 期刊論文	2019-07-11	Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates	-
[李秀珠] 期刊論文	2017-06-22	Targeting coronaviral replication and cellular JAK2 mediated dominant NF-kappaB activation for comprehensive and ultimate inhibition of coronaviral activity	-
[李秀珠] 期刊論文	2017-07	Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors	-
[翁紹華] 期刊論文	2017-05	1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine	-
[童俊維] 期刊論文	2017-01-31	SkinSensDB: A curated database for skin sensitization assays	-
[謝興邦] 期刊論文	2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[伍素瑩] 期刊論文	2016-04-12	Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)	-
[郭靜娟] 期刊論文	2015-12	Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model	-
[伍素瑩] 期刊論文	2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	-
[郭靜娟] 期刊論文	2015-08	Novel Nrf2/ARE activator, trans-coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38alpha/MAPKAPK-2 and PK-N3 signaling pathway	-
[謝興邦] 期刊論文	2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	-
[謝興邦] 期刊論文	2021-10-14	Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model	-
[蔣維棠] 期刊論文	2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	-
[徐祖安] 會議論文/會議摘要	2018-12	Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer	-
[郭書辰] 期刊論文	2018-06	Adding a C-terminal Cysteine (CTC) can enhance the bactericidal activity of three different Antimicrobial Peptides	-
[洪明秀] 會議論文/會議摘要	2016-12	Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy	-
[翁紹華] 期刊論文	2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	-
[陳慶餘(2006-2010)] 會議論文/會議摘要	2009-03	Relationship between serum uric acid and cerebral white matter lesion in the elderly	-
[郭書辰] 期刊論文	2014-10-06	The impact of dialysis therapy on older patients with advanced chronic kidney disease: A nationwide population-based study	-
[伍素瑩] 期刊論文	2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	-
[石全(2014-2017)] 會議論文/會議摘要	2020-08	BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification	-
[翁紹華] 會議論文/會議摘要	2019-07	Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216	-
[紀雅惠] 會議論文/會議摘要	2019-07	An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer	-

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