國家衛生研究院 NHRI:Item 3990099045/16294
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    题名: Differentiating the Abeta42 aggregation states via intrinsic tyrosine fluorescence spectrum
    其它题名: Differentiating the Aβ42 aggregation states via intrinsic tyrosine fluorescence spectrum
    作者: Yang, CT;Cheng, PY;Tsao, YC;Chen, HY;Wu, TH;Kao, TL;Kung, LC;Lin, SY;Chu, LK;Chiu, CC
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Aggregation of amyloid β-peptide (Aβ) into β-sheet-rich fibrils is central to the development of Alzheimer's disease, with Aβ42 more prone to aggregation over Aβ40. Using the intrinsic tyrosine fluorescence spectrum, we show that Aβ42 exhibits a biphasic fluorescence pattern featuring a broad band and a narrow one, distinct from Aβ40 and dissolved tyrosine. Molecular dynamics simulations highlighted the differences in tyrosine's rotamer populations and dynamics between dissolved and aggregated amyloids. Fibrillar Aβ42 shows slower, more uniform tyrosine rotations, corresponding to the narrower fluorescence band. This approach offers a rapid means to differentiate Aβ42 aggregates, benefiting Aβ-related research.
    日期: 2025-01
    關聯: Chemical Physics Letters. 2025 Jan;858:Article number 141739.
    Link to: http://dx.doi.org/10.1016/j.cplett.2024.141739
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-2614&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85208667817
    显示于类别:[林淑宜] 期刊論文

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