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    Items for Author "Chao, YS" 

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    Showing 213 items.

    Collection Date Title Relation Bitstream
    [陳炯東] 會議論文/會議摘要 2019-07 BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy -
    [謝興邦] 專利 2015-07-31 作為極光激酶抑制劑的稠合雙環嘧啶化合物 -
    [謝興邦] 專利 2015-07-22 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 -
    [岳嶽] 專利 2015-06-01 治療C型肝炎病毒感染之醫藥組成物 -
    [陳志豪] 專利 2015-05-29 Proline derivatives -
    [謝興邦] 專利 2015-04-14 Fused multicyclic compounds as protein kinase inhibitors -
    [夏克山] 專利 2015-02-24 Pyrazole compounds -
    [夏克山] 專利 2015-02-11 吡唑類化合物 -
    [夏克山] 專利 2014-11-19 咪唑-4-酮及咪唑-4-硫酮化合物 -
    [謝興邦] 專利 2014-10-29 作為極光激酶抑制劑的稠合雙環嘧啶化合物 -
    [謝興邦] 專利 2014-10-21 化合物於製造治療病毒感染的藥物之用途 -
    [謝奉勳] 專利 2014-09-01 治療阿茲海默症或帕金森氏症之醫藥組成物 -
    [葉燈光] 專利 2014-08-15 Anticancer oral formulation -
    [蔣維棠] 專利 2014-08-01 Pyrrolidine derivatives -
    [夏克山] 專利 2014-07-30 Pyrazole compounds -
    [葉燈光] 專利 2014-06-04 抗癌口服制剂 -
    [蔣維棠] 專利 2014-05-12 Pyrrolidine derivatives -
    [李秀珠] 專利 2014-05-11 二苯並〔f,h〕異喹啉衍生物及其醫藥組成物 -
    [蔣維棠] 專利 2014-05-08 Pyrrolidine derivatives -
    [謝興邦] 專利 2014-04-29 Quinoline compounds and their use for treating viral infection -
    [蔣維棠] 專利 2014-04-25 Pyrrolidine derivatives -
    [夏克山] 專利 2014-04-21 咪唑-4-酮及咪唑-4-硫酮化合物 -
    [蔣維棠] 專利 2014-04-21 作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途 -
    [李靜琪] 專利 2014-04-15 Glycoside compounds -
    [謝興邦] 專利 2014-03-20 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors -
    [陳志豪] 專利 2014-03-11 脯胺酸衍生物 -
    [蔣維棠] 專利 2014-02-19 Pyrrolidine derivatives -
    [蔣維棠] 專利 2013-12-18 吡咯烷化合物 -
    [謝興邦] 專利 2013-11-21 治療癌症的醫藥組成物 -
    [謝興邦] 專利 2013-10-01 喹啉化合物及包含其之治療病毒感染之醫藥組成物 -
    [蔣維棠] 專利 2013-09-27 Pyrrolidine derivatives -
    [夏克山] 專利 2013-09-11 噻吩化合物及其醫藥組成物 -
    [謝興邦] 專利 2013-08-21 Fused multicyclic compounds as protein kinase inhibitors -
    [謝興邦] 專利 2013-08-13 Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors -
    [李秀珠] 專利 2013-07-16 Dibenzo[f,h]isoquinoline derivatives -
    [謝興邦] 專利 2013-07-01 做為蛋白質激酶抑制劑之稠合多環化合物 -
    [葉燈光] 專利 2013-06-05 Anticancer oral formulation -
    [蔣維棠] 專利 2013-04-30 Pyrrolidine derivatives -
    [李秀珠] 會議論文/會議摘要 2013-04-13 Exploration of the role of tylophorine E ring in anti-Coronavirus activity-Tylophorine derived dibenzoquinolines impart multi-biological activities as orally active agents -
    [陳志豪] 專利 2013-04-09 Proline derivatives -
    [謝興邦] 會議論文/會議摘要 2013-04-07 BPR000K, a novel Aurora kinase inhibitor -
    [李秀珠] 會議論文/會議摘要 2013-04 Tylophorine induces c-Jun protein accumulation through two discrete prolonged pathways NF-kappaB/PKCdelta/JNK and PI3K/PDK1/PP2A/eEF2 to promote G1 arrest in carcinoma cells -
    [李秀珠] 會議論文/會議摘要 2013-04 Identification of a quinone compound inhibits human glutaminase activity and induces autophagy in carcinoma cells -
    [夏克山] 專利 2013-03-27 Thiophene compounds -
    [蔣維棠] 專利 2013-02-11 吡咯啉啶化合物 -
    [葉燈光] 專利 2013-02-11 抗癌口服藥學組成物 -
    [謝興邦] 專利 2013-02-11 作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物 -
    [夏克山] 專利 2013-01-15 Imidazol-4-one and imidazole-4-thione compounds -
    [夏克山] 專利 2012-07-04 噻吩化合物 -
    [蔣維棠] 專利 2012-06-15 Pyrrolidine derivatives -
    [謝奉勳] 專利 2012-06-12 Treatment of neurodegenerative disorders with thiourea compounds -
    [謝興邦] 專利 2012-05-11 作為極光激酶抑制劑之稠合雙環嘧啶化合物 -
    [蔣維棠] 專利 2012-04-21 吡咯啉啶化合物 -
    [陳志豪] 專利 2012-04-11 咪唑啉酮及咪唑啉硫酮衍生物 -
    [謝興邦] 專利 2012-03-20 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors -
    [陳志豪] 專利 2012-03-01 C型肝炎病毒抑制劑 -
    [蔣維棠] 專利 2012-01-17 Pyrrolidine compounds -
    [謝興邦] 專利 2011-11-15 Coumarin compounds and their use for treating cancer -
    [夏克山] 專利 2011-10-01 硒吩化合物及其醫藥組成物 -
    [葉燈光] 專利 2011-09-27 Formulations of indol-3-yl-2-oxoacetamide compounds -
    [蔣維棠] 專利 2011-09-20 Pyrrolidine derivatives -
    [夏克山] 專利 2011-08-11 噁二唑化合物 -
    [徐祖安] 專利 2011-07-26 Hepatitis C virus inhibitors -
    [徐祖安] 專利 2011-06-21 抑制冠狀病毒之醫藥組合物 -
    [徐祖安] 專利 2011-06-21 抑制冠狀病毒之醫藥組合物 -
    [徐祖安] 專利 2011-06-21 抑制冠狀病毒之醫藥組合物 -
    [蔣維棠] 專利 2011-05-25 Pyrrolidine derivatives -
    [陳志豪] 專利 2011-05-10 Imidazolidinone and imidazolidinethione derivatives -
    [夏克山] 專利 2011-03-21 吡唑化合物及其醫藥組成物 -
    [陳志豪] 專利 2011-03-01 Thiourea derivatives -
    [謝興邦] 專利 2010-12-01 吲哚化合物 -
    [謝興邦] 專利 2010-12-01 抗肿瘤化合物 -
    [夏克山] 專利 2010-11-16 Thiophene compounds -
    [蔣維棠] 專利 2010-10-06 吡咯烷化合物 -
    [夏克山] 專利 2010-09-28 Selenophene compounds -
    [陳志豪] 專利 2010-08-21 硫尿化合物及抑制C型肝炎病毒感染之方法 -
    [夏克山] 專利 2010-04-27 Oxadiazole compounds -
    [蔣維棠] 專利 2010-03-30 Pyrrolidine compounds -
    [謝興邦] 會議論文/會議摘要 2009-09 Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development -
    [徐祖安] 專利 2009-06-09 Treatment of coronavirus infection -
    [趙宇生(2002-2013)] 專利 2009-01-22 Pyrrolidine compounds -
    [謝興邦] 專利 2008-12-11 吲哚化合物 -
    [謝興邦] 專利 2008-11-25 Anti-tumor compounds -
    [謝興邦] 專利 2008-11-11 Indole compounds -
    [蔣維棠] 專利 2008-09-16 Pyrrolidine compounds -
    [蔣維棠] 專利 2008-07-21 吡咯啉啶化合物 -
    [蔣維棠] 專利 2008-07-01 Pyrrolidine compounds -
    [謝興邦] 專利 2008-05-01 抗腫瘤化合物 -
    [李秀珠] 會議論文/會議摘要 2007-04-18 Identification of novel small-molecule inhibitors of transmissible gastroenteritis virus -
    [謝興邦] 會議論文/會議摘要 2005-03 Promazine analogues as potential anti SARS-CoV drugs -
    [謝興邦] 會議論文/會議摘要 2005-03 Design, synthesis and sar of indole-based PPAR agonists -
    [謝興邦] 會議論文/會議摘要 2005-03 Design and structure-activity relationships of novel indole-based PPAR agonists as antidiabetic agents -
    [徐祖安] 期刊論文 2004-07 Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide -
    [趙宇生(2002-2013)] 期刊論文 2004-09 Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone -
    [謝興邦] 期刊論文 2005-12-29 Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities -
    [蔣維棠] 期刊論文 2006-01-12 2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV -
    [謝興邦] 期刊論文 2006-02-09 Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies -
    [伍素瑩] 期刊論文 2006-05-04 Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities -
    [蔣維棠] 期刊論文 2006-06-15 Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors -
    [伍素瑩] 期刊論文 2006-06-15 Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies -
    [伍素瑩] 期刊論文 2006-08-24 Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease -
    [謝興邦] 期刊論文 2006-10-19 Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists -
    [謝興邦] 期刊論文 2007-02-01 Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study -
    [蔣維棠] 期刊論文 2007-03-01 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes -
    [葉燈光] 期刊論文 2007-07 Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes -
    [葉燈光] 期刊論文 2007-10-01 Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry -
    [李秀珠] 期刊論文 2007-11 Novel small-molecule inhibitors of transmissible gastroenteritis virus -
    [夏克山] 期刊論文 2008-02-07 Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists -
    [徐祖安] 期刊論文 2008-04-01 A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71 -
    [謝興邦] 期刊論文 2008-03-01 Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold -
    [陳怡榮] 期刊論文 2008-06-01 A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors -
    [徐祖安] 期刊論文 2008-05 Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana -
    [陳炯東] 期刊論文 2008-07-09 Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice -
    [謝興邦] 會議論文/會議摘要 2010-08 Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models -
    [謝興邦] 會議論文/會議摘要 2007-07 Anti-influenza drug discovery -
    [徐祖安] 期刊論文 2010-01 BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses -
    [伍素瑩] 期刊論文 2009-10 (1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases -
    [謝興邦] 期刊論文 2010-02-25 Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives -
    [趙宇生(2002-2013)] 期刊論文 2010-02-23 Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity -
    [趙宇生(2002-2013)] 期刊論文 2010-07 Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 -
    [徐祖安] 期刊論文 2011-04 Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors -
    [蔣維棠] 期刊論文 2011-02 Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability -
    [謝興邦] 會議論文/會議摘要 2011-03-27 Design and synthesis of potent Aurora kinase inhibitors -
    [謝興邦] 期刊論文 2011-09 Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway -
    [謝興邦] 會議論文/會議摘要 2011-09-23 BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo -
    [趙宇生(2002-2013)] 會議論文/會議摘要 2012-11 BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia -
    [謝興邦] 會議論文/會議摘要 2013-04-07 Development drug candidate targeting EGFR kinase: DBPR112 -
    [謝興邦] 會議論文/會議摘要 2013-04 Design and synthesis of Aurora kinase inhibitors as anticancer agents -
    [謝興邦] 會議論文/會議摘要 2013-04-07 3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor -
    [謝興邦] 會議論文/會議摘要 2012-03-25 Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors -
    [翁紹華] 期刊論文 2016-01 Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy -
    [陳志豪] 期刊論文 2017-01 A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide -
    [徐祖安] 期刊論文 2014-01-08 Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer -
    [黃嘯谷] 期刊論文 2013-09-11 Environmental alkylphenols modulate cytokine expression in plasmacytoid dendritic cells -
    [蔣維棠] 期刊論文 2012-06-07 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [謝興邦] 期刊論文 2012-09 Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization -
    [謝興邦] 期刊論文 2010-06-15 Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification -
    [洪明秀] 期刊論文 2010-10 Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities -
    [夏克山] 期刊論文 2010-09 Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist -
    [趙宇生(2002-2013)] 期刊論文 2010-08 Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein -
    [趙宇生(2002-2013)] 期刊論文 2010-11 Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus -
    [趙宇生(2002-2013)] 期刊論文 2010-10 Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists -
    [趙宇生(2002-2013)] 期刊論文 2012-02 Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents -
    [趙宇生(2002-2013)] 期刊論文 2011-01 Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay -
    [趙宇生(2002-2013)] 期刊論文 2010-10-28 Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency -
    [陳炯東] 期刊論文 2010-12 Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening -
    [趙宇生(2002-2013)] 期刊論文 2011-03 Successful propagation of flavivirus infectious cDNAs by a novel method to reduce the cryptic bacterial promoter activity of virus genomes -
    [李靜琪] 期刊論文 2011-07-25 The first total synthesis of cytopiloyne, an anti-diabetic, polyacetylenic glucoside -
    [蔣維棠] 期刊論文 2011-07 Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [岳嶽] 期刊論文 2012-01 Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor -
    [徐祖安] 期刊論文 2012-01 BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML -
    [夏克山] 期刊論文 2012-02 Discovery of novel stem cell mobilizers that target the CXCR4 receptor -
    [徐祖安] 期刊論文 2012-01 A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors -
    [徐祖安] 期刊論文 2012-06 EGFR and myosin II inhibitors cooperate to suppress EGFR-T790M-mutant NSCLC cells -
    [岳嶽] 期刊論文 2013-02 Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems -
    [葉燈光] 期刊論文 2012-12-13 Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: Exploration of the role of tylophorine e ring on biological activity -
    [李秀珠] 期刊論文 2013-06 c-Jun-mediated anti-cancer mechanisms of tylophorine -
    [謝興邦] 期刊論文 2013-05 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules -
    [徐祖安] 期刊論文 2013-05 Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors -
    [謝興邦] 期刊論文 2013-06-28 Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor -
    [葉燈光] 期刊論文 2013-11 BPR0C305, an orally active microtubule-disrupting anticancer agent -
    [夏克山] 期刊論文 2013-11-13 Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice -
    [李秀珠] 期刊論文 2014-08 Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells -
    [葉修華] 期刊論文 2014-12-01 Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling -
    [洪明秀] 期刊論文 2015-05 A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis -
    [趙宇生(2002-2013)] 期刊論文 2015-07 Pharmacological induction of human fetal globin gene in hydroxyurea-resistant primary adult erythroid cells -
    [李秀珠] 期刊論文 2017-06-22 Targeting coronaviral replication and cellular JAK2 mediated dominant NF-kappaB activation for comprehensive and ultimate inhibition of coronaviral activity -
    [李靜琪] 期刊論文 2019-03 Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors -
    [翁紹華] 期刊論文 2022-11 Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone -
    [伍素瑩] 期刊論文 2008-08 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors -
    [夏克山] 期刊論文 2008-09-11 Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists -
    [夏克山] 期刊論文 2008-09-21 Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists -
    [李秀珠] 期刊論文 2008-10-15 Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma -
    [徐祖安] 期刊論文 2009-02 Aurintricarboxylic acid inhibits influenza virus neuraminidase -
    [陳志豪] 期刊論文 2009-04-01 Design, synthesis, and anti-HCV activity of thiourea compounds -
    [蔣維棠] 期刊論文 2009-04-01 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors -
    [蔣維棠] 期刊論文 2009-03-15 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors -
    [謝興邦] 期刊論文 2009-02-26 Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity -
    [伍素瑩] 期刊論文 2009-06 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] -
    [謝興邦] 期刊論文 2009-04-23 Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists -
    [陳新(2002-2015)] 期刊論文 2009-07-15 Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor -
    [李秀珠] 期刊論文 2009-08-14 Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression -
    [陳志豪] 期刊論文 2009-08-01 Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors -
    [夏克山] 期刊論文 2009-07-23 Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice -
    [伍素瑩] 期刊論文 2009-07-23 Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity -
    [陳志豪] 期刊論文 2009-11-01 Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors -
    [陳炯東] 期刊論文 2010-02 Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91 -
    [謝興邦] 期刊論文 2010-02-01 Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor -
    [陳炯東] 期刊論文 2010-03 Synthesis and biological activities of 2-Amino-1-arylidenamino imidazoles as orally active anticancer agents -
    [陳新(2002-2015)] 期刊論文 2010-06-15 (2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV -
    [趙宇生(2002-2013)] 期刊論文 2010-09-01 Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors -
    [陳炯東] 期刊論文 2011-01 BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities -
    [趙宇生(2002-2013)] 期刊論文 2011-01-13 Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes -
    [李秀珠] 期刊論文 2011-11 Isolation and biological activities of phenanthroindolizidine and septicine alkaloids from the formosan tylophora ovata -
    [夏克山] 期刊論文 2011-06 Hot topic: Opportunities and potential challenges for the treatment of metabolic syndrome -
    [洪明秀] 期刊論文 2012-07 Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors -
    [陳炯東] 期刊論文 2012-09 Putative tumor metastasis-associated genes in human gastric cancer -
    [翁紹華] 期刊論文 2014-08 Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors -
    [李靜琪] 期刊論文 2018-01-01 Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 -
    [翁紹華] 期刊論文 2018-04 4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy -
    [陳志豪] 期刊論文 2019-04-01 A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus -
    [翁紹華] 期刊論文 2019-04-01 The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone -
    [鄒倫] 期刊論文 2021-01 BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy -
    [陳炯東] 期刊論文 2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity -
    [岳嶽] 期刊論文 2013-05 Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus -
    [蔣維棠] 期刊論文 2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations -
    [李靜琪] 期刊論文 2015-07 Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors -
    [蔣維棠] 期刊論文 2013-06 Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [翁紹華] 期刊論文 2014-09 Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists -
    [李靜琪] 期刊論文 2016-05 N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors -
    [謝興邦] 期刊論文 2012-12 An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold -
    [謝興邦] 期刊論文 2013-01 3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor -
    [黃嘯谷] 期刊論文 2013-06 A common environmental pollutant, 4-nonylphenol, promotes allergic lung inflammation in a murine model of asthma -

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