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    Items for Author "Hsieh HP" 

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    Showing 228 items.

    Collection Date Title Relation Bitstream
    [葉修華] 期刊論文 2024-10-29 DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration -
    [林峯輝] 期刊論文 2024-06-24 Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease -
    [謝興邦] 期刊論文 2024-06-24 Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment -
    [張俊彥] 期刊論文 2024-05-09 Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function -
    [謝興邦] 期刊論文 2023-11-03 Influence of ring strain on the formation of rearrangement vs cyclization isotwistane products in the acyl radical reaction of bicyclo[2.2.2]octanone -
    [葉修華] 期刊論文 2023-10-05 A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects -
    [謝興邦] 會議論文/會議摘要 2023-10 Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs -
    [謝興邦] 期刊論文 2023-02-07 Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer -
    [謝興邦] 期刊論文 2022-09-12 A critical overview of current progress for COVID-19: Development of vaccines, antiviral drugs, and therapeutic antibodies -
    [謝興邦] 期刊論文 2022-08-09 Recent advances in total synthesis of natural products by masked ortho-benzoquinones -
    [謝興邦] 期刊論文 2022-05-09 Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer -
    [謝興邦] 期刊論文 2022-04-06 Identification of entry inhibitors against delta and omicron variants of SARS-CoV-2 -
    [顏婉菁] 期刊論文 2022-01-21 Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma -
    [謝興邦] 期刊論文 2021-11-15 Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization -
    [謝興邦] 期刊論文 2021-10-14 Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model -
    [黃明熙] 期刊論文 2021-07-16 Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens -
    [謝興邦] 期刊論文 2021-04-16 Development of a robust scale-up synthetic route for BPR1K871: A clinical candidate for the treatment of acute myeloid leukemia and solid tumors -
    [鄒倫] 期刊論文 2021-04-13 Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908) -
    [謝興邦] 期刊論文 2021-02-22 Mimicking H3 substrate arginine in the design of G9a lysine methyltransferase inhibitors for cancer therapy: A computational study for structure-based drug design -
    [謝興邦] 期刊論文 2021-01-31 Briarenols W-Z: Chlorine-containing polyoxygenated briaranes from octocoral briareum stechei (Kükenthal, 1908) -
    [謝興邦] 期刊論文 2021-01-15 One-pot synthesis of dibenzo[b,f]oxepines and total synthesis of bauhinoxepin C -
    [謝興邦] 期刊論文 2021-01 Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors -
    [謝興邦] 期刊論文 2020-12-10 Tumor-agnostic inhibitors in oncology: A new phase for precision medicine -
    [謝興邦] 期刊論文 2020-08 Design of a potent anticancer lead inspired by natural products from traditional Indian medicine -
    [謝興邦] 期刊論文 2020-07 Design of drug-like hepsin inhibitors against prostate cancer and kidney stones -
    [謝興邦] 期刊論文 2020-05 Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors -
    [謝興邦] 期刊論文 2020-03-01 A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis -
    [謝興邦] 期刊論文 2020-01 Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening -
    [張俊彥] 期刊論文 2019-12 Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry -
    [謝興邦] 期刊論文 2019-11-27 Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer -
    [喻秋華] 期刊論文 2019-10-08 Identification of two novel small compounds that inhibit liver cancer formation in zebrafish and analysis of their conjugation to nanodiamonds to further reduce toxicity -
    [葉燈光] 會議論文/會議摘要 2019-10 Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer -
    [謝興邦] 會議論文/會議摘要 2019-10 The molecular mechanisms of EpCAM in regulating tumor progression and development of anti-EpCAM antibodies for colon cancer diagnosis and therapy -
    [謝興邦] 期刊論文 2019-07-03 Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: A molecular dynamics study -
    [謝興邦] 期刊論文 2019-07 Dual Kit/Aur inhibitors as chemosensitizing agents for the treatment of melanoma: Design, synthesis, docking studies and functional investigation -
    [謝興邦] 期刊論文 2019-05-29 Insights for the design of protein lysine methyltransferase G9a inhibitors -
    [謝興邦] 期刊論文 2018-11 Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D -
    [謝興邦] 會議論文/會議摘要 2018-07 Clinical candidate DBPR112: A novel epidermal growth factor receptor inhibitor as a promising treatment for non-small cell lung cancer -
    [郭靜娟] 會議論文/會議摘要 2018-07 Blockage of EGFR signaling repurposes tumor metabolism through suppression of glycolysis and Kreb cycle in head and neck cancer -
    [紀雅惠] 期刊論文 2018-05-10 Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition -
    [陳炯東] 會議論文/會議摘要 2018-01 Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer -
    [謝興邦] 期刊論文 2017-08-11 Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer -
    [謝興邦] 期刊論文 2017-07 Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors -
    [葉燈光] 會議論文/會議摘要 2017-04 Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation -
    [謝興邦] 會議論文/會議摘要 2017-04 Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone -
    [謝興邦] 會議論文/會議摘要 2017-04 One-pot tandem oxidative dearomatization/ 4+3 cycloaddition: Masked o-benzoquinone with diaza-oxyallyl cation -
    [謝興邦] 期刊論文 2016-12 Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation -
    [謝興邦] 期刊論文 2016-11-29 Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design -
    [謝興邦] 期刊論文 2016-07 Therapeutic polymeric nanoparticles and the methods of making and using thereof: A patent evaluation of WO2015036792 -
    [謝興邦] 期刊論文 2016-03 Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target survivin -
    [謝興邦] 會議論文/會議摘要 2015-08 BPR2P001S0, a Coumarin derivative, induced cell cycle arrest in A549 through inhibiting PDPK1 activity -
    [陳炯東] 會議論文/會議摘要 2015-08 Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia -
    [謝興邦] 會議論文/會議摘要 2015-08 Optimization of furanopyrimidine-based kinase inhibitors: Identification of a BTK kinase inhibitor for the treatment of B cell lymphoma -
    [謝興邦] 會議論文/會議摘要 2015-08 Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors -
    [謝興邦] 專利 2015-07-31 作為極光激酶抑制劑的稠合雙環嘧啶化合物 -
    [謝興邦] 專利 2015-07-22 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 -
    [謝興邦] 期刊論文 2015-06-29 Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification -
    [謝興邦] 專利 2015-04-14 Fused multicyclic compounds as protein kinase inhibitors -
    [夏克山] 期刊論文 2015-02 Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors -
    [徐祖安] 期刊論文 2015-01 Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity -
    [謝興邦] 期刊論文 2014-12 BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71 -
    [謝興邦] 會議論文/會議摘要 2014-11 Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent -
    [謝興邦] 專利 2014-10-29 作為極光激酶抑制劑的稠合雙環嘧啶化合物 -
    [謝興邦] 專利 2014-10-21 化合物於製造治療病毒感染的藥物之用途 -
    [謝興邦] 期刊論文 2014-10 Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer -
    [謝興邦] 會議論文/會議摘要 2014-10 Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML -
    [謝興邦] 會議論文/會議摘要 2014-10 Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma -
    [謝興邦] 期刊論文 2014-08 CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors -
    [謝興邦] 期刊論文 2014-08 Ligand efficiency based approach for efficient virtual screening of compound libraries -
    [謝興邦] 期刊論文 2014-07 Anaplastic lymphoma kinase (ALK) inhibitors: A review of design and discovery -
    [謝興邦] 期刊論文 2014-05 Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach -
    [徐祖安] 期刊論文 2014-05 Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014) -
    [謝興邦] 專利 2014-04-29 Quinoline compounds and their use for treating viral infection -
    [謝興邦] 專利 2014-03-20 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors -
    [徐祖安] 會議論文/會議摘要 2014-03 DBPR112, a potent and selective EGFR kinase inhibitor in preclinical study -
    [謝興邦] 會議論文/會議摘要 2014-03 Efficient virtual screening using ligand efficiency based approach -
    [謝興邦] 專利 2013-11-21 治療癌症的醫藥組成物 -
    [葉燈光] 會議論文/會議摘要 2013-11 A development drug candidate targeting EGFR kinase for lung cancer: DBPR112 -
    [謝興邦] 會議論文/會議摘要 2013-11 Peptide-mediated liposomal doxorubicin enhances drug delivery efficiency and therapeutic efficacy in lung cancer animal models -
    [謝興邦] 專利 2013-10-01 喹啉化合物及包含其之治療病毒感染之醫藥組成物 -
    [徐祖安] 期刊論文 2013-09-22 A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411] -
    [謝興邦] 專利 2013-08-21 Fused multicyclic compounds as protein kinase inhibitors -
    [謝興邦] 專利 2013-08-13 Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors -
    [謝興邦] 期刊論文 2013-07-25 Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway -
    [謝興邦] 專利 2013-07-01 做為蛋白質激酶抑制劑之稠合多環化合物 -
    [謝興邦] 期刊論文 2013-06-28 Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor -
    [謝興邦] 期刊論文 2013-06 An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells -
    [謝興邦] 期刊論文 2013-05 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules -
    [徐祖安] 期刊論文 2013-05 Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors -
    [徐祖安] 期刊論文 2013-04-29 A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment -
    [謝興邦] 會議論文/會議摘要 2013-04-07 BPR000K, a novel Aurora kinase inhibitor -
    [謝興邦] 會議論文/會議摘要 2013-04-07 Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis -
    [謝興邦] 會議論文/會議摘要 2013-04-07 3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor -
    [謝興邦] 會議論文/會議摘要 2013-04-07 Development drug candidate targeting EGFR kinase: DBPR112 -
    [謝興邦] 會議論文/會議摘要 2013-04 Design and synthesis of Aurora kinase inhibitors as anticancer agents -
    [徐祖安] 期刊論文 2013-02-20 Parallel screening of Wild-Type and drug-resistant targets for anti-resistance neuraminidase inhibitors -
    [謝興邦] 專利 2013-02-11 作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物 -
    [謝興邦] 期刊論文 2013-01 3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor -
    [謝興邦] 期刊論文 2013-01 Substituent effects on the photorearrangements of unsymmetrically substituted diazinobarrelenes -
    [謝興邦] 期刊論文 2012-12 An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold -
    [謝興邦] 期刊論文 2012-09 Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization -
    [謝興邦] 期刊論文 2012-08-24 Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts -
    [謝興邦] 專利 2012-05-11 作為極光激酶抑制劑之稠合雙環嘧啶化合物 -
    [蔣維棠] 專利 2012-04-21 吡咯啉啶化合物 -
    [謝興邦] 會議論文/會議摘要 2012-03-25 Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors -
    [謝興邦] 專利 2012-03-20 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors -
    [謝興邦] 專利 2012-03-06 Indole compounds -
    [徐祖安] 期刊論文 2012-02 Identification of BPR3P0128 as an Inhibitor of cap-snatching activities of influenza virus -
    [蔣維棠] 專利 2012-01-17 Pyrrolidine compounds -
    [徐祖安] 期刊論文 2012-01 A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors -
    [謝興邦] 專利 2011-11-15 Coumarin compounds and their use for treating cancer -
    [謝興邦] 會議論文/會議摘要 2011-09-23 BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo -
    [張俊彥] 期刊論文 2011-09 Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents -
    [謝興邦] 期刊論文 2011-09 Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway -
    [張俊彥] 期刊論文 2011-08 BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells -
    [謝興邦] 專利 2011-07-11 抑制C型肝炎病毒感染之倍半帖內酯類化合物及其醫藥組成物 -
    [徐祖安] 專利 2011-06-21 抑制冠狀病毒之醫藥組合物 -
    [徐祖安] 專利 2011-06-21 抑制冠狀病毒之醫藥組合物 -
    [徐祖安] 專利 2011-06-21 抑制冠狀病毒之醫藥組合物 -
    [謝興邦] 期刊論文 2011-06 Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10) -
    [謝興邦] 期刊論文 2011-04-28 Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents -
    [謝興邦] 專利 2011-04-06 Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis related disorders -
    [謝興邦] 會議論文/會議摘要 2011-04 Antivascular activities of novel tubulin binding agent BPR0L075 -
    [謝興邦] 會議論文/會議摘要 2011-03-27 Design and synthesis of potent Aurora kinase inhibitors -
    [陳立宗] 期刊論文 2011-03-07 2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors -
    [謝興邦] 會議論文/會議摘要 2011-03 SAR studies of quinoline derivatives as novel anti-influenza agents -
    [徐祖安] 會議論文/會議摘要 2011-03 Potent EGFR tyrosine kinase inhibitors as anticancer agents -
    [謝興邦] 專利 2010-12-01 吲哚化合物 -
    [謝興邦] 專利 2010-12-01 抗肿瘤化合物 -
    [趙宇生(2002-2013)] 期刊論文 2010-10-28 Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency -
    [蔣維棠] 專利 2010-10-06 吡咯烷化合物 -
    [趙宇生(2002-2013)] 期刊論文 2010-10 Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists -
    [張俊彥] 期刊論文 2010-09 Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes -
    [謝興邦] 會議論文/會議摘要 2010-08 Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models -
    [趙宇生(2002-2013)] 期刊論文 2010-07 Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 -
    [謝興邦] 期刊論文 2010-06-15 Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification -
    [張文祥] 期刊論文 2010-06 Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis -
    [蔣維棠] 專利 2010-03-30 Pyrrolidine compounds -
    [張俊彥] 期刊論文 2010-03-11 5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors -
    [謝興邦] 期刊論文 2010-02-25 Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives -
    [趙宇生(2002-2013)] 期刊論文 2010-02-23 Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity -
    [謝興邦] 期刊論文 2010-02-01 Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor -
    [謝興邦] 期刊論文 2010-02 Comparative molecular field analysis of anti-tubulin agents with indole ring binding at the colchicine binding site -
    [徐祖安] 期刊論文 2010-01 BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses -
    [謝興邦] 專利 2009-12-15 Indole compounds -
    [謝興邦] 專利 2009-12-01 芳香羰吲哚化合物 -
    [謝興邦] 會議論文/會議摘要 2009-09 Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development -
    [謝興邦] 期刊論文 2009-08-13 Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach -
    [伍素瑩] 期刊論文 2009-07-23 Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity -
    [張俊彥] 期刊論文 2009-07-03 Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers -
    [徐祖安] 專利 2009-06-09 Treatment of coronavirus infection -
    [謝興邦] 專利 2009-05-05 Indole compounds -
    [謝興邦] 會議論文/會議摘要 2009-05 Down-regulation of survivin enhances sensitivity to BPROL075 in human cancer cells via caspase-independent mechanisms -
    [其他] 期刊論文 2009-04-24 Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway -
    [謝興邦] 期刊論文 2009-04-23 Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists -
    [張俊彥] 期刊論文 2009-04-17 Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents -
    [張俊彥] 期刊論文 2009-04 Aurora kinase inhibitors in preclinical and clinical testing -
    [謝興邦] 期刊論文 2009-03 Advances in Aurora kinase inhibitor patents -
    [謝興邦] 會議論文/會議摘要 2009-03 Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors -
    [謝興邦] 期刊論文 2009-02-26 Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity -
    [徐祖安] 期刊論文 2009-02 Aurintricarboxylic acid inhibits influenza virus neuraminidase -
    [趙宇生(2002-2013)] 專利 2009-01-22 Pyrrolidine compounds -
    [謝興邦] 期刊論文 2008-12-25 Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents -
    [謝興邦] 專利 2008-12-11 吲哚化合物 -
    [謝興邦] 專利 2008-11-25 Anti-tumor compounds -
    [謝興邦] 專利 2008-11-11 Indole compounds -
    [蔣維棠] 專利 2008-09-16 Pyrrolidine compounds -
    [張俊彥] 期刊論文 2008-07-24 Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors -
    [蔣維棠] 專利 2008-07-21 吡咯啉啶化合物 -
    [蔣維棠] 專利 2008-07-01 Pyrrolidine compounds -
    [謝興邦] 期刊論文 2008-07 Anti-HSV activity of digitoxin and its possible mechanisms -
    [陳怡榮] 期刊論文 2008-06-01 A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors -
    [謝興邦] 專利 2008-05-01 抗腫瘤化合物 -
    [徐祖安] 期刊論文 2008-05 Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana -
    [陳新(2002-2015)] 期刊論文 2008-04-15 Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus -
    [謝興邦] 期刊論文 2008-03-13 Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors -
    [謝興邦] 期刊論文 2008-03-10 Reactions of 2-hydroxybenzophenones with Corey-Chaykovsky reagent -
    [謝興邦] 期刊論文 2008-03-01 Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold -
    [徐祖安] 專利 2008-02-11 一種抗病毒之醫藥組合物 -
    [謝興邦] 期刊論文 2008-02-07 First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol -
    [張俊彥] 期刊論文 2008-02 A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells -
    [謝興邦] 期刊論文 2007-12 Strategies of development of antiviral agents directed against influenza virus replication -
    [張俊彥] 期刊論文 2007-09-06 4-and 5-aroylindoles as novel classes of potent antitubulin agents -
    [張俊彥] 期刊論文 2007-07-31 Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil -
    [葉燈光] 期刊論文 2007-07 Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes -
    [謝興邦] 會議論文/會議摘要 2007-07 Anti-influenza drug discovery -
    [謝興邦] 會議論文/會議摘要 2007-07 From bench to drug candidate: Design and synthesis of 5,6-fused heteroaromatics as anticancer agents -
    [蔣維棠] 期刊論文 2007-03-01 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes -
    [賴基銘(2004-2008)] 期刊論文 2007-02-08 Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells -
    [謝興邦] 期刊論文 2007-02-01 Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study -
    [陳炯東] 期刊論文 2006-12 Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats -
    [張俊彥] 期刊論文 2006-11-16 7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents -
    [謝興邦] 期刊論文 2006-10-19 Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists -
    [謝興邦] 期刊論文 2006-10 Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents -
    [謝興邦] 會議論文/會議摘要 2006-09 MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes -
    [伍素瑩] 期刊論文 2006-08-24 Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease -
    [謝興邦] 期刊論文 2006-07 Antiviral drug discovery against SARS-CoV -
    [伍素瑩] 期刊論文 2006-06-15 Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies -
    [蔣維棠] 期刊論文 2006-06-15 Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors -
    [伍素瑩] 期刊論文 2006-05-04 Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities -
    [謝興邦] 期刊論文 2006-05 Antitubulin agents for the treatment of cancer - a medicinal chemistry update -
    [謝興邦] 期刊論文 2006-02-09 Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies -
    [蔣維棠] 期刊論文 2006-01-12 2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV -
    [謝興邦] 期刊論文 2006-01-01 Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system -
    [謝興邦] 期刊論文 2005-12-29 Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities -
    [謝興邦] 專利 2005-08-23 Indole compounds -
    [謝興邦] 期刊論文 2005-05 Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells - Role of NF-kappa B -
    [謝興邦] 期刊論文 2005-05 Pharmaceutical design of antimitotic agents based on combretastatins -
    [謝興邦] 會議論文/會議摘要 2005-03 Promazine analogues as potential anti SARS-CoV drugs -
    [謝興邦] 會議論文/會議摘要 2005-03 Design, synthesis and sar of indole-based PPAR agonists -
    [謝興邦] 會議論文/會議摘要 2005-03 Design and structure-activity relationships of novel indole-based PPAR agonists as antidiabetic agents -
    [徐祖安] 期刊論文 2005 Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3 '- digallate (TF3) -
    [徐祖安] 期刊論文 2004-09-10 Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV -
    [李秀珠] 會議論文/會議摘要 2004-09 Drug design of BPR0L075 as an anticancer agent -
    [謝興邦] 會議論文/會議摘要 2004-08-22 Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents -
    [謝興邦] 期刊論文 2004-08-12 Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents -
    [張俊彥] 期刊論文 2004-07-15 A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells -
    [張俊彥] 期刊論文 2004-07-01 BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo -
    [徐祖安] 期刊論文 2004-07 Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide -
    [李秀珠] 會議論文/會議摘要 2004-07 Drug design for BPR0L075 as an anticancer agent -
    [謝興邦] 期刊論文 2004-05-20 Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents -
    [謝興邦] 期刊論文 2003-12-01 Substituent effects on di-pi-methane and aza-di-pi-methane rearrangements of dibenzo[f,h]quinoxalinobarrelenes -
    [陳立宗] 期刊論文 2003-06-15 Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent -
    [張俊彥] 期刊論文 2003-03-10 Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents (vol 13, pg 101, 2003) -
    [張俊彥] 期刊論文 2003-01-06 Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents -
    [李秀珠] 會議論文/會議摘要 2003 The synthetic 1-aroylindoles and 3-aroylindoles derivatives, combretastatin A-4 analogues, as a novel class of potent anticancer agents -
    [謝興邦] 會議論文/會議摘要 2002-08 Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents -
    [謝興邦] 期刊論文 2002-06-06 Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents -

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