國家衛生研究院 NHRI:Items for Author

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Items for Author "Ke, YY"

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Showing 45 items.

Collection	Date	Title	Relation
[石全(2014-2017)] 會議論文/會議摘要	2020-08	BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification	-
[紀雅惠] 會議論文/會議摘要	2019-07	An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer	-
[郭靜娟] 會議論文/會議摘要	2018-07	Blockage of EGFR signaling repurposes tumor metabolism through suppression of glycolysis and Kreb cycle in head and neck cancer	-
[葉燈光] 會議論文/會議摘要	2017-04	Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[謝興邦] 會議論文/會議摘要	2014-10	Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML	-
[謝興邦] 會議論文/會議摘要	2014-03	Efficient virtual screening using ligand efficiency based approach	-
[謝興邦] 期刊論文	2011-09	Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway	-
[謝興邦] 會議論文/會議摘要	2013-04-07	3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor	-
[謝興邦] 會議論文/會議摘要	2015-08	Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors	-
[陳炯東] 會議論文/會議摘要	2015-08	Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia	-
[謝興邦] 期刊論文	2019-07	Dual Kit/Aur inhibitors as chemosensitizing agents for the treatment of melanoma: Design, synthesis, docking studies and functional investigation	-
[葉燈光] 會議論文/會議摘要	2019-10	Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer	-
[黃智興] 期刊論文	2024-07-04	Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells	-
[夏克山] 期刊論文	2016-12-08	Bromomethylthioindole inspired carbazole hybrids as promising class of anti-MRSA agents	-
[謝興邦] 期刊論文	2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	-
[謝興邦] 期刊論文	2013-06-28	Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor	-
[謝興邦] 期刊論文	2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	-
[夏克山] 期刊論文	2015-02	Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors	-
[謝興邦] 期刊論文	2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	-
[謝興邦] 期刊論文	2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[葉修華] 期刊論文	2017-03	Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers	-
[李秀珠] 期刊論文	2017-07	Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors	-
[夏克山] 期刊論文	2018-02-08	Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond	-
[陳炯東] 期刊論文	2020-08	Artificial intelligence approach fighting COVID-19 with repurposing drugs	-
[李秀珠] 期刊論文	2020-08	Repurposing old drugs as antiviral agents for coronaviruses	-
[徐祖安] 期刊論文	2020-08-20	Discovery of M protease inhibitors encoded by SARS-CoV-2	-
[紀雅惠] 期刊論文	2021-05-19	Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins	-
[其他] 期刊論文	2021-11	Characterization of a mutated KCNJ5 gene, G387R, in unilateral primary aldosteronism	-
[翁紹華] 期刊論文	2022-11	Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone	-
[紀雅惠] 期刊論文	2024-06-01	Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus	-
[謝興邦] 期刊論文	2014-05	Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach	-
[徐祖安] 期刊論文	2015-01	Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity	-
[夏克山] 期刊論文	2018-07	Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology	-
[謝興邦] 期刊論文	2018-04-25	Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors	-
[紀雅惠] 期刊論文	2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	-
[翁紹華] 期刊論文	2019-04-01	The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone	-
[陳炯東] 期刊論文	2020-10-08	Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery	-
[夏克山] 期刊論文	2021-03-30	A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment	-
[張明姿] 期刊論文	2021-10	Chemoproteomic profiling reveals cellular targets of nitro-fatty acids	-
[翁紹華] 期刊論文	2022-12-05	Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation	-
[李靜琪] 期刊論文	2023-10-05	Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease	-
[謝興邦] 期刊論文	2016-11-29	Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design	-
[翁紹華] 期刊論文	2017-01	Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists	-
[謝興邦] 期刊論文	2013-01	3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor	-
[徐祖安] 期刊論文	2014-05	Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)	-

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Items for Author "Ke, YY"