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    Items for Author "Jiaang, WT" 

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    Showing 64 items.

    Collection Date Title Relation Bitstream
    [郭靜娟] 期刊論文 2021-08-12 Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) -
    [陳炯東] 期刊論文 2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity -
    [蔣維棠] 期刊論文 2021-01 Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease -
    [蔣維棠] 期刊論文 2019-12 Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia -
    [翁紹華] 會議論文/會議摘要 2019-07 Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216 -
    [喻秋華] 期刊論文 2019-05-28 Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform -
    [伍素瑩] 期刊論文 2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants -
    [陳立宗] 期刊論文 2018-08-24 BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor -
    [陳炯東] 會議論文/會議摘要 2016-12 Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST -
    [蔡慧珍] 期刊論文 2016-10 BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia -
    [伍素瑩] 期刊論文 2016-04-12 Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK) -
    [蔣維棠] 期刊論文 2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations -
    [蔣維棠] 專利 2014-08-01 Pyrrolidine derivatives -
    [蔣維棠] 專利 2014-05-12 Pyrrolidine derivatives -
    [蔣維棠] 專利 2014-05-08 Pyrrolidine derivatives -
    [蔣維棠] 專利 2014-04-25 Pyrrolidine derivatives -
    [蔣維棠] 專利 2014-04-21 作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途 -
    [蔣維棠] 專利 2014-02-19 Pyrrolidine derivatives -
    [陳新(2002-2015)] 期刊論文 2014-02 Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation -
    [徐祖安] 期刊論文 2014-01-08 Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer -
    [岳嶽] 期刊論文 2014-01 A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease -
    [蔣維棠] 專利 2013-12-18 吡咯烷化合物 -
    [蔣維棠] 專利 2013-09-27 Pyrrolidine derivatives -
    [謝興邦] 期刊論文 2013-06-28 Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor -
    [蔣維棠] 期刊論文 2013-06 Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [蔣維棠] 專利 2013-04-30 Pyrrolidine derivatives -
    [蔣維棠] 專利 2013-02-11 吡咯啉啶化合物 -
    [陳新(2002-2015)] 專利 2013-02-11 吡咯啶化合物 -
    [岳嶽] 期刊論文 2013-02 Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems -
    [蔣維棠] 專利 2012-06-15 Pyrrolidine derivatives -
    [蔣維棠] 期刊論文 2012-06-07 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [蔣維棠] 專利 2012-04-21 吡咯啉啶化合物 -
    [蔣維棠] 專利 2012-01-17 Pyrrolidine compounds -
    [岳嶽] 期刊論文 2012-01 Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor -
    [徐祖安] 期刊論文 2012-01 BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML -
    [陳新(2002-2015)] 專利 2011-12-06 Pyrrolidine compounds -
    [蔣維棠] 專利 2011-09-20 Pyrrolidine derivatives -
    [蔣維棠] 期刊論文 2011-07 Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [陳新(2002-2015)] 期刊論文 2011-06 Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate -
    [蔣維棠] 期刊論文 2011-06 Current advances and therapeutic potential of agents targeting dipeptidyl peptidases-IV, -II, 8/9 and fibroblast activation protein -
    [蔣維棠] 專利 2011-05-25 Pyrrolidine derivatives -
    [蔣維棠] 期刊論文 2011-02 Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability -
    [蔣維棠] 專利 2010-10-06 吡咯烷化合物 -
    [陳新(2002-2015)] 期刊論文 2010-09 The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities -
    [趙宇生(2002-2013)] 期刊論文 2010-08 Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein -
    [陳新(2002-2015)] 期刊論文 2010-06-15 (2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV -
    [蔣維棠] 專利 2010-03-30 Pyrrolidine compounds -
    [伍素瑩] 期刊論文 2009-10 (1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases -
    [陳新(2002-2015)] 期刊論文 2009-07-15 Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor -
    [伍素瑩] 期刊論文 2009-06 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] -
    [蔣維棠] 期刊論文 2009-04-01 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors -
    [蔣維棠] 期刊論文 2009-03-15 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors -
    [趙宇生(2002-2013)] 專利 2009-01-22 Pyrrolidine compounds -
    [蔣維棠] 專利 2008-09-16 Pyrrolidine compounds -
    [伍素瑩] 期刊論文 2008-08 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors -
    [蔣維棠] 專利 2008-07-21 吡咯啉啶化合物 -
    [蔣維棠] 專利 2008-07-01 Pyrrolidine compounds -
    [蔣維棠] 期刊論文 2007-03-01 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes -
    [謝興邦] 會議論文/會議摘要 2006-09 MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes -
    [蔣維棠] 期刊論文 2006-06-15 Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors -
    [蔣維棠] 期刊論文 2006-01-12 2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV -
    [蔣維棠] 期刊論文 2005-07-01 Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors -
    [李秀珠] 期刊論文 2005-04-15 Benzothiazolium compounds: Novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFN gamma -
    [陳新(2002-2015)] 期刊論文 2005-02-01 Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8 -

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