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    Items for Author "Chen, CT" 

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    Showing 291 items.

    Collection Date Title Relation Bitstream
    [葉修華] 期刊論文 2024-10-29 DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration -
    [葉修華] 期刊論文 2024-07-17 Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia -
    [紀雅惠] 期刊論文 2024-06-01 Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus -
    [陳炯東] 期刊論文 2024-02-16 Postfermented tea extract potently alleviates glucose metabolism disorders in vitro and in vivo -
    [吳其炘] 期刊論文 2024-01-25 Unlocking the secrets behind advanced artificial intelligence language models in deidentifying Chinese-English mixed clinical text: Development and validation study -
    [吳嘉文] 期刊論文 2023-09-07 Controlled encapsulation of gold nanoparticles into Zr-metal-organic frameworks with improved detection limitation of volatile organic compounds via surface-enhanced raman scattering -
    [其他] 期刊論文 2023-09 Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway -
    [李秀珠] 期刊論文 2023-07-20 Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin -
    [羅履維] 期刊論文 2023-06-02 Illuminating and radiosensitizing tumors with 2DG-bound gold-based nanomedicine for targeted CT imaging and therapy -
    [謝興邦] 期刊論文 2023-02-07 Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer -
    [李秀珠] 期刊論文 2023-01-19 The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b [Erratum:Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.] -
    [翁紹華] 期刊論文 2022-12-05 Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation -
    [劉士任] 期刊論文 2022-12-02 Omicron-specific mRNA vaccine induced cross-protective immunity against ancestral SARS-CoV-2 infection with low neutralizing antibodies -
    [陳炯東] 期刊論文 2022-11-15 BPR0C261, an analogous of microtubule disrupting agent D-24851 enhances the radiosensitivity of human non-small cell lung cancer cells via p53-dependent and p53-independent pathways -
    [陳炯東] 期刊論文 2022-11-01 Peritoneal effluent MicroRNA profile for detection of encapsulating peritoneal sclerosis -
    [翁紹華] 期刊論文 2022-11 Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone -
    [陳炯東] 期刊論文 2022-10-13 Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate -
    [夏克山] 期刊論文 2022-10-03 Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention -
    [李秀珠] 期刊論文 2022-07-21 The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b -
    [羅履維] 期刊論文 2022-07-13 Multimodal magnetic resonance and photoacoustic imaging of tumor-specific enzyme-responsive hybrid nanoparticles for oxygen modulation -
    [鄒倫] 期刊論文 2022-06-21 Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids -
    [余冠儀] 期刊論文 2022-05-02 Furin and TMPRSS2 resistant spike induces robust humoral and cellular immunity against SARS-CoV-2 lethal infection -
    [張俊彥] 期刊論文 2022-03-02 Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy -
    [鄒倫] 期刊論文 2022-02-15 Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates -
    [陳炯東] 期刊論文 2021-12 Implanted islet mass influences the effects of dipeptidyl peptidase-IV inhibitor LAF237 on transplantation outcomes in diabetic mice -
    [謝興邦] 期刊論文 2021-11-15 Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization -
    [謝興邦] 期刊論文 2021-10-14 Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model -
    [陳炯東] 期刊論文 2021-10-01 Engineering nano- and microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport -
    [李秀珠] 期刊論文 2021-08-13 Remdesivir and cyclosporine synergistically inhibit the human coronaviruses OC43 and SARS-CoV-2 -
    [陳炯東] 期刊論文 2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity -
    [陳炯東] 期刊論文 2021-08 A noninvasive gut-to-brain oral drug delivery system for treating brain tumors -
    [紀雅惠] 期刊論文 2021-05-19 Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins -
    [陳主智] 期刊論文 2021-03 Projection of future temperature extremes, related mortality, and adaptation due to climate and population changes in Taiwan -
    [蕭金福] 期刊論文 2021-01 Use of a two-sided tolerance interval in the design and evaluation of biosimilarity in clinical studies -
    [鄒倫] 期刊論文 2021-01 BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy -
    [蔣維棠] 期刊論文 2021-01 Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease -
    [李秀珠] 期刊論文 2020-12-14 Inhibition of SARS-CoV-2 by highly potent broad-spectrum anti-coronaviral tylophorine-based derivatives -
    [陳炯東] 期刊論文 2020-11 Molecular profiling of afatinib-resistant non-small cell lung cancer cells in vivo derived from mice -
    [陳炯東] 期刊論文 2020-10-08 Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery -
    [陳炯東] 期刊論文 2020-10 A bubble bursting-mediated oral drug delivery system that enables concurrent delivery of lipophilic and hydrophilic chemotherapeutics for treating pancreatic tumors in rats -
    [蕭金福] 期刊論文 2020-10 Operational experiences in China and statistical issues on the conduct of clinical trials during the COVID-19 pandemic -
    [徐祖安] 期刊論文 2020-08-20 Discovery of M protease inhibitors encoded by SARS-CoV-2 -
    [陳炯東] 期刊論文 2020-08 Artificial intelligence approach fighting COVID-19 with repurposing drugs -
    [李秀珠] 期刊論文 2020-08 Repurposing old drugs as antiviral agents for coronaviruses -
    [石全(2014-2017)] 會議論文/會議摘要 2020-08 BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification -
    [羅履維] 期刊論文 2020-05-20 Annealing-modulated nanoscintillators for nonconventional X-ray activation of comprehensive photodynamic effects in deep cancer theranostics -
    [劉滄梧] 期刊論文 2020-02-18 Impacts of intralipid on nanodrug abraxane therapy and on the innate immune system -
    [岳嶽] 期刊論文 2019-12 A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses -
    [蔣維棠] 期刊論文 2019-12 Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia -
    [謝興邦] 期刊論文 2019-11-27 Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer -
    [羅履維] 期刊論文 2019-11 A novel mouse model of sporadic colon cancer induced by combination of conditional Apc genes and chemical carcinogen in the absence of cre recombinase -
    [顏婉菁] 會議論文/會議摘要 2019-10 Inhibition of Rspo-Wnt pathway facilitates checkpoint blockade therapy by anti-RSPO3 antibody (DBPR117) -
    [陳炯東] 期刊論文 2019-09 Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1 -
    [岳嶽] 期刊論文 2019-08-27 A dengue virus type 2 (DENV-2) NS4B-interacting host factor, SERP1, reduces DENV-2 production by suppressing viral RNA replication -
    [鄒倫] 期刊論文 2019-07-11 Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates -
    [陳炯東] 期刊論文 2019-07 Citronellol induces necroptosis of human lung cancer cells via TNF-alpha pathway and reactive oxygen species accumulation -
    [翁紹華] 會議論文/會議摘要 2019-07 Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216 -
    [陳炯東] 會議論文/會議摘要 2019-07 BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy -
    [紀雅惠] 會議論文/會議摘要 2019-07 An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer -
    [陳炯東] 期刊論文 2019-06-15 Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems -
    [其他] 會議論文/會議摘要 2019-05 Assessment of photodynamic therapy (PDT) efficacy of X-ray activated nanoscintillators using F-18-HT in PET -
    [伍素瑩] 期刊論文 2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants -
    [陳志豪] 期刊論文 2019-04-01 A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus -
    [翁紹華] 期刊論文 2019-04-01 The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone -
    [羅履維] 期刊論文 2019-04 Highly sensitive electron paramagnetic resonance nanoradicals for quantitative intracellular tumor oxymetric images -
    [陳炯東] 期刊論文 2019-03-28 Phase-changeable nanoemulsions for oral delivery of a therapeutic peptide: Toward targeting the pancreas for antidiabetic treatments using lymphatic transport -
    [李靜琪] 期刊論文 2019-03 Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors -
    [岳嶽] 期刊論文 2019-03 Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A -
    [陳炯東] 期刊論文 2019-01 CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma -
    [陳炯東] 期刊論文 2019-01 CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-Beta Wnt and STAT3 signaling pathways -
    [徐祖安] 會議論文/會議摘要 2018-12 Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer -
    [徐祖安] 會議論文/會議摘要 2018-12 Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer -
    [郭書辰] 期刊論文 2018-10 Community-acquired bloodstream infections caused by Acinetobacter baumannii: A matched case-control study -
    [陳立宗] 期刊論文 2018-08-24 BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor -
    [蕭金福] 圖書 2018-08-21 Design and data analysis of multiregional clinical trials (MRCTs)—Theory and practice -
    [陳炯東] 期刊論文 2018-07 An intestinal "Transformers"-like nanocarrier system for enhancing the oral bioavailability of poorly water-soluble drugs -
    [翁紹華] 會議論文/會議摘要 2018-07 4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo -
    [郭書辰] 期刊論文 2018-06 Risk of mortality of Catheter-Related Bloodstream Infections caused by acinetobacter species: Is early removal of the catheters associated with a better survival outcome? -
    [郭書辰] 期刊論文 2018-05 Biofilm formation is not associated with worse outcome in Acinetobacter baumannii bacteraemic pneumonia -
    [陳炯東] 期刊論文 2018-04 Effects of female sex hormones on folic acid-induced anti-angiogenesis -
    [陳炯東] 期刊論文 2018-04 PSPC1 mediates TGF-beta1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis -
    [夏克山] 期刊論文 2018-02-08 Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond -
    [李靜琪] 期刊論文 2018-01-01 Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 -
    [陳炯東] 會議論文/會議摘要 2018-01 Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer -
    [郭靜娟] 期刊論文 2017-12 Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells -
    [鄒小蕙] 期刊論文 2017-09 A tolerance interval approach to assessing the biosimilarity of follow-on biologics -
    [郭書辰] 期刊論文 2017-09 Multicenter study of the relationship between carbapenem MIC values and clinical outcome of patients with Acinetobacter Bacteremia -
    [郭書辰] 期刊論文 2017-09 Multicenter study of clinical features of breakthrough acinetobacter bacteremia during carbapenem therapy -
    [羅履維] 期刊論文 2017-09 Rapid measurement of fluorescence lifetimes using SiPM detection and waveform sampling -
    [羅履維] 期刊論文 2017-08 Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions -
    [陳炯東] 期刊論文 2017-07-07 CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-kappaB pathways -
    [李秀珠] 期刊論文 2017-07 Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors -
    [鄒倫] 期刊論文 2017-07 Targeting tumor associated phosphatidylserine with new zinc dipicolylamine-based drug conjugates -
    [翁紹華] 期刊論文 2017-05 1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine -
    [葉燈光] 會議論文/會議摘要 2017-04 Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation -
    [謝興邦] 期刊論文 2016-12 Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation -
    [陳炯東] 會議論文/會議摘要 2016-12 Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST -
    [蕭金福] 會議論文/會議摘要 2016-11-11 Assessing benefit and consistency of treatment effect under a discrete random effects model in multiregional clinical trials -
    [羅履維] 會議論文/會議摘要 2016-10-29 Rapid measurement of fluorescence lifetimes using SIPM detection and waveform sampling -
    [蔡慧珍] 期刊論文 2016-10 BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia -
    [陳炯東] 會議論文/會議摘要 2016-10 Multifunctional nanoparticles for oral protein drug delivery -
    [陳炯東] 會議論文/會議摘要 2016-08 Dipeptidyl peptidase-4 inhibitor LAF-237 improves glucose tolerance and expends graft beta cell mass in diabetic mice transplanted with a sufficient number of islets -
    [蕭金福] 期刊論文 2016-06 Assessing the consistency of the treatment effect under the discrete random effects model in multiregional clinical trials -
    [李靜琪] 期刊論文 2016-05 N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors -
    [楊重熙] 會議論文/會議摘要 2016-05 In Vivo PET/CT neuroimaging of radiolabeled nanocarriers following intranasal drug delivery (INDD): Validation using Ex Vivo PET/CT, gamma counting and autoradiography -
    [羅履維] 會議論文/會議摘要 2016-05 Experimental model validation for x-ray induced luminescence imaging in tissue phantoms with europium-doped nanophosphors -
    [羅履維] 期刊論文 2016-02 Dynamic in vivo SPECT imaging of neural stem cells functionalized with radiolabeled nanoparticles for tracking of glioblastoma -
    [陳炯東] 會議論文/會議摘要 2016-02 Multifunctional nanoparticles for oral protein drug delivery -
    [陳炯東] 期刊論文 2015-09 Self-assembling bubble carriers for oral protein delivery -
    [郭書辰] 期刊論文 2015-08 Risk factors and outcome for colistin resistant acinetobacter nosocomialis bacteraemia in patients without previous colistin exposure -
    [郭靜娟] 期刊論文 2015-08 Novel Nrf2/ARE activator, trans-coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38alpha/MAPKAPK-2 and PK-N3 signaling pathway -
    [陳炯東] 會議論文/會議摘要 2015-08 Zinc-dipicolylamine directed pharmaceutical delivery system (ZAPS) as an innovative cancer drug delivery platform -
    [陳炯東] 會議論文/會議摘要 2015-08 Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia -
    [蔣維棠] 期刊論文 2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations -
    [羅履維] 會議論文/會議摘要 2015-05 Evaluation of X-ray fuorescence emission tomography for real-time assessment of photodynamic therapy effect -
    [劉柯俊] 期刊論文 2015-04 IL-1beta promotes malignant transformation and tumor aggressiveness in oral cancer -
    [夏克山] 期刊論文 2015-03 Stem cell mobilizers targeting chemokine receptor CXCR4: Renoprotective application in acute kidney injury -
    [羅履維] 期刊論文 2014-11 Radioluminescence characterization of in situ x-ray nanodosimeters: Potential real-time monitors and modulators of external beam radiation therapy -
    [謝興邦] 會議論文/會議摘要 2014-11 Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent -
    [陳炯東] 會議論文/會議摘要 2014-10 YYEI motif is critical to oncogenicity of 14-3-3 proteins -
    [謝興邦] 會議論文/會議摘要 2014-10 Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma -
    [葉燈光] 專利 2014-08-15 Anticancer oral formulation -
    [羅履維] 期刊論文 2014-08-07 Significant inhibition of tumor growth following single dose nanoparticle-enhanced photodynamic therapy -
    [陳炯東] 期刊論文 2014-08-04 Effects of dipeptidyl peptidase-4 inhibition with MK-0431 on syngeneic mouse islet transplantation -
    [葉燈光] 專利 2014-06-04 抗癌口服制剂 -
    [羅履維] 期刊論文 2014-05-30 Enhanced plasmonic resonance energy transfer in mesoporous silica-encased gold nanorod for two-photon-activated photodynamic therapy -
    [羅履維] 會議論文/會議摘要 2014-05 Nanoparticle-engineered probing of neural stem cells targeted therapy for glioblastoma -
    [羅履維] 會議論文/會議摘要 2014-05 Direct x-ray luminescence tomography using selective plane illumination -
    [陳炯東] 期刊論文 2014-04 Treatment of chemotherapy-induced neutropenia in a rat model by using multiple daily doses of oral administration of G-CSF-containing nanoparticles -
    [羅履維] 圖書 2014-03 Silica nanoparticle platform -
    [徐祖安] 會議論文/會議摘要 2014-03 DBPR112, a potent and selective EGFR kinase inhibitor in preclinical study -
    [徐祖安] 期刊論文 2014-01-08 Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer -
    [羅履維] 期刊論文 2013-12 Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy -
    [鄒小蕙] 期刊論文 2013-11 A 12-Year ecological study of hip fracture rates among older Taiwanese adults -
    [葉燈光] 期刊論文 2013-11 BPR0C305, an orally active microtubule-disrupting anticancer agent -
    [葉燈光] 會議論文/會議摘要 2013-11 A development drug candidate targeting EGFR kinase for lung cancer: DBPR112 -
    [陳炯東] 期刊論文 2013-10 Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats -
    [陳炯東] 期刊論文 2013-10 Combination therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT -
    [羅履維] 會議論文/會議摘要 2013-09-08 Nanoparticle-programmed self-destructive neural stem cells for targeted glioblastoma therapy -
    [羅履維] 期刊論文 2013-07 Theranostic applications of mesoporous silica nanoparticles and their organic/inorganic hybrids -
    [陳炯東] 期刊論文 2013-07 Andrographis paniculata extract and andrographolide modulate the hepatic drug metabolism system and plasma tolbutamide concentrations in rats -
    [謝興邦] 期刊論文 2013-06-28 Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor -
    [葉燈光] 專利 2013-06-05 Anticancer oral formulation -
    [蔣維棠] 期刊論文 2013-06 Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [陳炯東] 期刊論文 2013-06 Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence -
    [陳炯東] 期刊論文 2013-05 H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline in senescent human fetal mesenchymal stem cells -
    [謝興邦] 期刊論文 2013-05 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules -
    [謝興邦] 會議論文/會議摘要 2013-04-07 BPR000K, a novel Aurora kinase inhibitor -
    [謝興邦] 會議論文/會議摘要 2013-04-07 Development drug candidate targeting EGFR kinase: DBPR112 -
    [謝興邦] 會議論文/會議摘要 2013-04 Design and synthesis of Aurora kinase inhibitors as anticancer agents -
    [葉燈光] 專利 2013-02-11 抗癌口服藥學組成物 -
    [夏興國] 期刊論文 2013-02 Targeted endostatin-cytosine deaminase fusion gene therapy plus 5-fluorocytosine suppresses ovarian tumor growth -
    [陳炯東] 期刊論文 2013-01-23 In vivo imaging of brain infarct with the novel fluorescent probe psvue 794 in a rat middle cerebral artery occlusion-reperfusion model -
    [陳炯東] 期刊論文 2013-01 Effects of pH on molecular mechanisms of chitosan–integrin interactions and resulting tight-junction disruptions -
    [羅履維] 期刊論文 2012-12 Recent advances in nanoparticle-based föster resonance energy transfer for biosensing, molecular imaging and drug release profiling -
    [趙宇生(2002-2013)] 會議論文/會議摘要 2012-11 BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia -
    [陳炯東] 期刊論文 2012-09 Elucidating the signaling mechanism of an epithelial tight-junction opening induced by chitosan -
    [李靜琪] 期刊論文 2012-09 Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors -
    [蕭金福] 期刊論文 2012-09 Design and evaluation of multiregional trials with heterogeneous treatment effect across regions -
    [陳炯東] 期刊論文 2012-09 Putative tumor metastasis-associated genes in human gastric cancer -
    [陳炯東] 期刊論文 2012-09 HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy -
    [林名釗] 期刊論文 2012-08 Ferritin-red fluorescent protein fusion reporter for magnetic resonance and optical imaging -
    [蔣維棠] 期刊論文 2012-06-07 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [陳炯東] 會議論文/會議摘要 2012-06 Involvement of transcriptional regulator Ndt80 in stress responses of Candida albicans -
    [羅履維] 期刊論文 2012-04-19 Visualizing dynamics of sub-hepatic distribution of nanoparticles using intravital multiphoton fluorescence microscopy -
    [陳炯東] 期刊論文 2012-04 Securin enhances the anti-cancer effects of 6-Methoxy-3-(3′,4′,5′-Trimethoxy-Benzoyl)-1H-Indole (BPR0L075) in human colorectal cancer cells -
    [羅履維] 會議論文/會議摘要 2012-03-25 Biocompatible gold nanomaterials for optoacoustic imaging (OAI) -
    [羅秀容] 期刊論文 2012-03 R432 is a key residue for the multiple functions of Ndt80p in Candida albicans -
    [趙宇生(2002-2013)] 期刊論文 2012-02 Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents -
    [夏克山] 期刊論文 2012-02 Discovery of novel stem cell mobilizers that target the CXCR4 receptor -
    [徐祖安] 期刊論文 2012-01 BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML -
    [林嬪嬪] 期刊論文 2012-01 Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models -
    [陳炯東] 期刊論文 2011-11 Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins -
    [陳炯東] 期刊論文 2011-10 Antiproliferative effects of N-heterocyclic indolyl glyoxylamide derivatives on human lung cancer cells -
    [葉燈光] 專利 2011-09-27 Formulations of indol-3-yl-2-oxoacetamide compounds -
    [陳炯東] 會議論文/會議摘要 2011-09 Effects of dipeptidyl peptidase 4 inhibition with MK-0431 on syngeneic mouse islet transplantation -
    [蕭樑基] 期刊論文 2011-07 Immune response and pathophysiological features of Klebsiella pneumoniae liver abscesses in an animal model -
    [蔣維棠] 期刊論文 2011-07 Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [陳炯東] 期刊論文 2011-05 Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4 -
    [陳炯東] 會議論文/會議摘要 2011-05 Study of glioblastoma multiforme metastatic and invasive mechanism by polycistronic imaging probe in tumor implanted animal model -
    [謝興邦] 會議論文/會議摘要 2011-03-27 Design and synthesis of potent Aurora kinase inhibitors -
    [趙宇生(2002-2013)] 期刊論文 2011-01-13 Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes -
    [陳炯東] 期刊論文 2011-01 BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities -
    [陳炯東] 期刊論文 2010-12 Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening -
    [陳炯東] 期刊論文 2010-11 Self-assembled pH-sensitive nanoparticles: A platform for oral delivery of protein drugs -
    [陳炯東] 期刊論文 2010-11 Do neutrophils play a role in establishing liver abscesses and distant metastases caused by Klebsiella pneumoniae? -
    [趙宇生(2002-2013)] 期刊論文 2010-10-28 Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency -
    [林名釗] 期刊論文 2010-10 RU486-inducible recombination in the salivary glands of lactoferrin promoter-driven green fluorescent Cre transgenic mice -
    [陳炯東] 期刊論文 2010-09 Intravenous paclitaxel against metastasis of human gastric tumors of diffuse type -
    [羅履維] 期刊論文 2010-08 Tri-functionalization of mesoporous silica nanoparticles for comprehensive cancer theranostics-the trio of imaging, targeting and therapy -
    [謝興邦] 會議論文/會議摘要 2010-08 Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models -
    [羅履維] 期刊論文 2010-07 Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles -
    [趙宇生(2002-2013)] 期刊論文 2010-07 Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 -
    [陳新(2002-2015)] 期刊論文 2010-06-15 (2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV -
    [陳炯東] 專利 2010-05-11 咪唑胺化合物 -
    [陳志豪] 專利 2010-05-11 咪唑啉酮化合物 -
    [陳炯東] 專利 2010-04-21 吲哚-3-基-2-氧乙醯胺衍生物之新化合物及其醫藥組合物與製備方法 -
    [林名釗] 期刊論文 2010-04 Detection of experimentally induced pulmonary granuloma Inflammation in monocyte chemoattractant protein-1 reporter mice -
    [何英剛(2006-2011)] 期刊論文 2010-03 Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice -
    [陳炯東] 期刊論文 2010-03 Synthesis and biological activities of 2-Amino-1-arylidenamino imidazoles as orally active anticancer agents -
    [陳淑貞(1998-2001)] 專利 2010-02-16 Methods of 1H-indol-3-yl-2-oxoacetamide compounds -
    [蔡世峯] 期刊論文 2010-02-09 ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway -
    [陳炯東] 期刊論文 2010-02 Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91 -
    [陳炯東] 期刊論文 2010-02 Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice -
    [羅履維] 期刊論文 2010-01 Enhanced photoacoustic stability of gold nanorods by silica matrix confinement -
    [蔡世峯] 期刊論文 2009-10-09 KEAP1 E3 Ligase-Mediated Downregulation of NF-kappaB Signaling by Targeting IKKbeta -
    [林名釗] 期刊論文 2009-10 Noninvasive optical imaging for tracking gene delivery and recombination in tumor -
    [伍素瑩] 期刊論文 2009-10 (1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases -
    [蕭子凱(2001-2004)] 專利 2009-08-21 一種定量迦瑪射線能量、高峰時間及衰減時間常數的裝置及其使用方法 -
    [謝興邦] 期刊論文 2009-08-13 Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach -
    [陳炯東] 專利 2009-08-04 Imidazolamino compounds -
    [伍素瑩] 期刊論文 2009-07-23 Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity -
    [葉燈光] 期刊論文 2009-07 Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes -
    [蕭子凱(2001-2004)] 專利 2009-06-19 A device and method for digitizing pet radiation events -
    [蔣維棠] 期刊論文 2009-04-01 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors -
    [陳炯東] 期刊論文 2009-04 In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery -
    [張文祥] 期刊論文 2009-04 ALA-PDT results in phenotypic changes and decreased cellular invasion in surviving cancer cells -
    [蕭子凱(2001-2004)] 專利 2009-03-19 A device and method for digitizing gamma ray energy and characterizing peak time and decay time constant without the use of ADC -
    [蔣維棠] 期刊論文 2009-03-15 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors -
    [陳志豪] 專利 2009-03-10 Imidazolidinone compounds -
    [羅秀容] 期刊論文 2009-03 Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells -
    [羅履維] 期刊論文 2009-01-23 Near-infrared mesoporous silica nanoparticles for optical imaging: Characterization and in vivo biodistribution -
    [蕭子凱(2001-2004)] 專利 2009-01-02 A device and method for digitizing gamma ray energy and characterizing peak time and decay time constant without the use Of ADC -
    [陳炯東] 專利 2008-12-09 Imidazolamino compounds -
    [陳炯東] 期刊論文 2008-11-28 Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10) -
    [陳炯東] 期刊論文 2008-09 Human breast tumor cells express multimodal imaging reporter genes -
    [陳炯東] 期刊論文 2008-07-09 Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice -
    [陳炯東] 專利 2008-07-08 Use of 1H-indol-3-yl-2-oxoacetamide compounds -
    [陳炯東] 期刊論文 2008-06 Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation -
    [蕭子凱(2001-2004)] 專利 2008-03-11 Device and method for digitizing PET radiation events -
    [黃秀芬] 期刊論文 2008-03 Decreased expression of UK114 is related to the differentiation status of human hepatocellular carcinoma -
    [葉燈光] 期刊論文 2008-02-28 Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet -
    [林名釗] 會議論文/會議摘要 2007-11 A unified segmentation method for CT image segmentation with contrast agent -
    [其他] 會議論文/會議摘要 2007-10 Least-square pinhole SPECT calibration using a forward projector modeling misalignment -
    [梁賡義] 期刊論文 2007-08 A randomised placebo-controlled trial of a traditional chinese herbal formula in the treatment of primary dysmenorrhoea -
    [葉燈光] 期刊論文 2007-07 Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes -
    [陳志豪] 專利 2007-06-01 咪唑啉酮化合物 -
    [其他] 期刊論文 2007-06 Improved accuracy of brain MRI/SPECT registration using a two-cluster SPECT normalization algorithm and a combinative similarity measure: application to the evaluation of Parkinson's disease -
    [其他] 期刊論文 2007-05 An automatic MRI/SPECT registration algorithm using image intensity and anatomical feature as matching characters: application on the evaluation of Parkinson's disease -
    [蕭子凱(2001-2004)] 專利 2007-04-03 Device and method for digitizing gamma ray energy and characterizing peak time and decay time constant without the use of ADC -
    [陳炯東] 期刊論文 2007-03-14 Novel nanoparticles for oral insulin delivery via the paracellular pathway -
    [蔣維棠] 期刊論文 2007-03-01 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes -
    [陳炯東] 期刊論文 2007-03 Effects of paclitaxel and doxorubicin in histocultures of hepatocelular carcinomas -
    [蕭子凱(2001-2004)] 專利 2007-02-11 一種數位化正子斷層掃瞄發射裝置及其使用方法 -
    [謝興邦] 期刊論文 2007-02-01 Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study -
    [陳炯東] 期刊論文 2007-01 Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery -
    [其他] 會議論文/會議摘要 2007 A system model for pinhole SPECT simulating edge penetration, detector and pinhole response and non-uniform attenuation -
    [陳炯東] 期刊論文 2006-12 Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats -
    [葉燈光] 期刊論文 2006-11-25 The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes -
    [陳志豪] 專利 2006-10-31 Imidazolidinone compounds -
    [其他] 會議論文/會議摘要 2006-10 New ray-driven system matrix for small-animal pinhole-SPECT with detector blur, geometric response and edge penetration modeling -
    [陳炯東] 專利 2006-09-19 Imidazolamino compounds -
    [謝興邦] 會議論文/會議摘要 2006-09 MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes -
    [陳炯東] 期刊論文 2006-08 Impaired phagocytosis of capsular serotypes K1 or K2 Klebsiella pneumoniae in type 2 diabetes mellitus patients with poor glycemic control -
    [羅秀容] 期刊論文 2006-07 Non-lethal Candida albicans cph1/cph1 efg1/efg1 transcription factor mutant establishing restricted zone of infection in a mouse model of systemic infection -
    [蔣維棠] 期刊論文 2006-06-15 Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors -
    [伍素瑩] 期刊論文 2006-05-04 Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities -
    [陳炯東] 期刊論文 2006-03 Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system for the treatment of liver cancer -
    [陳炯東] 期刊論文 2006-03 Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system against cultured HepG2 cells -
    [其他] 會議論文/會議摘要 2006-03 A novel model of the geometric and detector response for limited angular sampling pinhole SPECT -
    [蔣維棠] 期刊論文 2006-01-12 2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV -
    [謝興邦] 期刊論文 2005-12-29 Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities -
    [林名釗] 會議論文/會議摘要 2005-10 A row-action image reconstruction of short time frame for microPET dynamic study -
    [蕭子凱(2001-2004)] 期刊論文 2005-08 A new approach for pulse processing in positron emission tomography -
    [陳炯東] 期刊論文 2005-05 Loading of a novel angiogenic agent, ginsenoside Rg(1) in an acellular biological tissue for tissue regeneration -
    [陳炯東] 期刊論文 2005-04 A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration -
    [陳炯東] 專利 2005-03-01 一種用以抑制癌細胞之醫藥組合物 -
    [陳炯東] 期刊論文 2005-03 Preparation of nanoparticles composed of chitosan/poly-gamma-glutamic acid and evaluation of their permeability through Caco-2 cells -
    [涂醒哲(2003-2004)] 期刊論文 2005-03 SARS in Taiwan: an overview and lessons learned -
    [謝興邦] 會議論文/會議摘要 2005-03 Design, synthesis and sar of indole-based PPAR agonists -
    [謝興邦] 會議論文/會議摘要 2005-03 Design and structure-activity relationships of novel indole-based PPAR agonists as antidiabetic agents -
    [其他] 會議論文/會議摘要 2004-10 A preliminary experimental valiadation of a new approach for pulse processing in PET -
    [李秀珠] 會議論文/會議摘要 2004-09 Drug design of BPR0L075 as an anticancer agent -
    [陳炯東] 期刊論文 2004-08-10 Inhibition of human vascular endothelial cells proliferation by terbinafine -
    [張俊彥] 期刊論文 2004-07-01 BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo -
    [李秀珠] 會議論文/會議摘要 2004-07 Drug design for BPR0L075 as an anticancer agent -
    [陳炯東] 期刊論文 2004-04 Central pressor effects of CART peptides in anesthetized rats -
    [周玉山(1996-2005)] 期刊論文 2004-03-19 Diverse cellular transformation capability of overexpressed genes in human hepatocellular carcinoma -
    [莊聲宏(1997-2004)] 期刊論文 2004-03 Expression of cytoplasmic-domain substituted epidermal growth factor receptor inhibits tumorigenicity of EGFR-overexpressed human glioblastoma multiforme -
    [陳炯東] 期刊論文 2004-02 A simple quantitative method for evaluation of angiogenesis activity -
    [張文祥] 會議論文/會議摘要 2004 ALA-mediated photodynamic therapy decreases the ability of cellular invasion in CL1-5 human lung adenocarcinoma cells -
    [陳炯東] 會議論文/會議摘要 2004 Acellular biological tissues loaded with a novel angiogenic agent (ginsenoside Rg1) as a tissue-engineering extracellular matrix -
    [其他] 會議論文/會議摘要 2004 Modular detector systems for nuclear medicine imaging -
    [張文祥] 會議論文/會議摘要 2004 ALA-mediated photodynamic therapy decreases the ability of cellular invasion in CL1-5 human lung adenocarcinoma cells -
    [蕭子凱(2001-2004)] 會議論文/會議摘要 2003-10 A new approach for pulse processing in PET -
    [陳炯東] 期刊論文 2003-04-24 Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents -
    [林名釗] 圖書 2003 Functional and molecular imaging using positron emission tomography -
    [彭汪嘉康(1996-2007)] 期刊論文 2002-05 Phase II and pharmacokinetic study of GL331 in previously treated Chinese gastric cancer patients -
    [陳炯東] 會議論文/會議摘要 2002-03 Sympathoinhibitory action of nociceptin in the rat spinal cord -
    [陳炯東] 期刊論文 2001-06 Time- and concentration-dependent penetration of doxorubicin in prostate tumors -
    [其他] 期刊論文 1998-10 Characterization of p96(h2bk): Immunoreaction with an anti-Erk (extracellular-signal-regulated kinase) peptide antibody and activity in Xenopus oocytes and eggs -

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