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    類別 日期 題名 關聯 檔案
    [廖倫德] 期刊論文 2024-10-24 Comprehensive validation of a compact laser speckle contrast imaging system for vascular function assessment: From the laboratory to the clinic -
    [廖倫德] 期刊論文 2024-10-14 Digital transformation of mental health therapy by integrating digitalized cognitive behavioral therapy and eye movement desensitization and reprocessing -
    [許佳賢] 期刊論文 2024-10-08 The hanging-heart chip: A portable microfluidic device for high-throughput generation of contractile embryonic stem cell-derived cardiac spheroids -
    [廖倫德] 期刊論文 2024-09-25 Exploring the use of deep learning models for accurate tracking of 3D zebrafish trajectories -
    [羅秀容] 期刊論文 2024-08-31 Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020 -
    [蘇勇曄] 期刊論文 2024-08-28 Clinical outcomes and histologic findings of patients with hepatocellular carcinoma with durable partial response or durable stable disease after receiving atezolizumab plus bevacizumab -
    [許佳賢] 期刊論文 2024-08-14 Tape-assisted fabrication method for constructing PDMS membrane-containing culture devices with cyclic radial stretching stimulation -
    [其他] 期刊論文 2024-02-10 Synthesis of porous TiO2/SiO2 monodisperse hollow spheres as a platform for phosphopeptide enrichment -
    [蘇勇曄] 期刊論文 2024-02-01 Outcomes of post-immunotherapy durable responders of advanced hepatocellular carcinoma- with emphasis on locoregional therapy for oligoprogression -
    [廖倫德] 期刊論文 2024-01-29 Improvement of clinical wound microcirculation diagnosis using an object tracking-based laser speckle contrast imaging system -
    [王朝永] 期刊論文 2024-01 2024 TSOC/TSPS joint consensus: Strategies for advanced vascular wound management in arterial and venous diseases -
    [杜鴻運] 期刊論文 2023-12-11 Pathological granuloma fibrosis induced by agar-embedded Mycobacterium abscessus in C57BL/6JNarl mice -
    [熊昭] 期刊論文 2023-12-01 Country-level factors associated with nurse salaries: Empirical evidence from organisation for economic co-operation and development countries and Taiwan -
    [許佳賢] 圖書 2023-10-25 Microfluidic diagnostics and drug-delivery platforms for the early diagnosis and treatment of bacterial diseases -
    [許佳賢] 期刊論文 2023-08-08 A microfluidic countercurrent reactor for accelerating enzymatic reactions -
    [許佳賢] 期刊論文 2023-06-05 Evaluating the biological effectiveness of boron neutron capture therapy by using microfluidics-based pancreatic tumor spheroids -
    [姜乃榕] 會議論文/會議摘要 2023-06 Phase 1 studies of D07001-F4 and D07001-softgel capsule: Oral metronomic gemcitabine in subjects with advanced solid tumors -
    [吳嘉文] 期刊論文 2022-12-01 Poly(acrylic acid)-grafted metal-organic framework carrying Mg ions for bone repair -
    [廖玉潔] 期刊論文 2022-11 Engineered multivalent DNA capsules for multiplexed detection of genotoxicants via versatile controlled release mechanisms -
    [陳立宗] 會議論文/會議摘要 2022-10 Outcomes of post-immunotherapy durable responders of advanced hepatocellular carcinoma - with emphasis on locoregional therapy for oligoprogression -
    [許佳賢] 期刊論文 2022-07 A micro-pupil device for point-of-care testing of viable Escherichia coli in tap water -
    [陳為堅] 期刊論文 2022-06-25 Mitochondrial DNA methylation profiling of the human prefrontal cortex and nucleus accumbens: Correlations with aging and drug use -
    [羅秀容] 期刊論文 2022-06 Genetic relatedness among azole-resistant Candida tropicalis clinical strains in Taiwan from 2014 to 2018 -
    [許佳賢] 圖書 2022-04-01 Nanotechnology in healthcare: Nanoparticles for diagnostic and therapy -
    [許佳賢] 期刊論文 2022-03-29 A microfluidic hanging drop-based spheroid co-culture platform for probing tumor angiogenesis -
    [許佳賢] 期刊論文 2022-02 A portable controllable compressive stress device to monitor human breast cancer cell protrusions at single-cell resolution -
    [姜乃榕] 會議論文/會議摘要 2022-02 Phase 1 study of nanoliposomal irinotecan in combination with trifluridine/tipiracil in refractory solid tumors -
    [杜鴻運] 期刊論文 2021-11-17 Alginate-capped silver nanoparticles as a potent anti-mycobacterial agent against mycobacterium tuberculosis -
    [許佳賢] 期刊論文 2021-11-08 Microfluidic technology for multiple single-cell capture -
    [許佳賢] 期刊論文 2021-10-29 Dual-well microfluidic technique for single cell isolation and long-term clonal culture -
    [杜鴻運] 期刊論文 2021-08-11 Characterization of virus replication, pathogenesis, and cytokine responses in syrian hamsters inoculated with SARS-CoV-2 -
    [許佳賢] 期刊論文 2021-08-01 A simple magnetic-assisted microfluidic method for rapid detection and phenotypic characterization of ultralow concentrations of bacteria -
    [江運金] 期刊論文 2021-05 Does Nicastrin inadequacy cause melanocytotoxicity in human skin as in the fish counterpart? -
    [杜鴻運] 期刊論文 2021-03 Activation of M1 macrophages in response to recombinant TB vaccines with enhanced Antimycobacterial Activity[Erratum:Frontiers in Immunology. 2020 Jun:Article number 01298.] -
    [許佳賢] 期刊論文 2020-09-18 High-sensitivity SERS based sensing on the labeling side of glass slides using low branched gold nanoparticles prepared with surfactant-free synthesis -
    [許佳賢] 期刊論文 2020-06-18 A microfluidic Single-Cell Cloning (SCC) device for the generation of monoclonal cells -
    [杜鴻運] 期刊論文 2020-06 Activation of M1 macrophages in response to recombinant TB vaccines with enhanced Antimycobacterial Activity -
    [許佳賢] 期刊論文 2020-05-10 Rabies virus glycoprotein-amplified hierarchical targeted hybrids capable of magneto-electric penetration delivery to orthotopic brain tumor -
    [林峯輝] 期刊論文 2020-04 The preparation of cell-containing microbubble scaffolds to mimic alveoli structure as 3D drug screening system for lung cancer -
    [陳立宗] 期刊論文 2020-04 Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours -
    [陳立宗] 期刊論文 2020-03 Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with intermediate and advanced/relapsed hepatocellular carcinoma: A TOS-ESMO initiative endorsed by CSCO, ISMPO, JSMO, KSMO, MOS and SSO -
    [許佳賢] 期刊論文 2020-02-27 Light energy conversion surface with gold dendritic nanoforests/Si chip for plasmonic polymerase chain reaction -
    [江運金] 期刊論文 2020-02 Nicastrin deficiency induces tyrosinase-dependent depigmentation and skin inflammation -
    [許佳賢] 會議論文/會議摘要 2020-02 A 3D culture combinatorial drug screening device -
    [許佳賢] 會議論文/會議摘要 2019-11 Microfluidic chip for single-cell interaction anaysis -
    [林名釗] 圖書 2019-10-31 Cardiac myopathy in conditional Hsp60 transgenic mice -
    [邱英明] 期刊論文 2019-10 Generation of high aspect-ratio pdms microfibers for 3D myelination culture of schwann cells -
    [許佳賢] 期刊論文 2019-09-27 Establishing single-cell based co-cultures in a deterministic manner with a microfluidic chip -
    [林名釗] 期刊論文 2019-07-31 A Tri-fusion reporter mouse reveals tissue-specific FGF1B promoter activity in vivo -
    [林峯輝] 期刊論文 2019-07-12 The effect of the repression of oxidative stress on tenocyte differentiation: A preliminary study of a rat cell model using a novel differential tensile strain bioreactor -
    [許佳賢] 期刊論文 2019-06 Multilayer architecture microfluidic network array for combinatorial drug testing on 3D-cultured cells -
    [許佳賢] 期刊論文 2019-05-02 Peanut detection using droplet microfluidic polymerase chain reaction device -
    [陳雅雯] 期刊論文 2019-04 Hydrodynamic shuttling for deterministic high-efficiency multiple single-cell capture in a microfluidic chip -
    [林峯輝] 期刊論文 2019-03 Drug-loaded hyaluronic acid hydrogel as a sustained-release regimen with dual effects in early intervention of tendinopathy -
    [許佳賢] 會議論文/會議摘要 2018-11 A microfluidic chip for multiple single-cell interaction analysis -
    [許佳賢] 會議論文/會議摘要 2018-11 Microfluidic chip for generating single cell-derived monoclonal cell populations -
    [李岳倫] 期刊論文 2018-10 Identification of novel Cdc7 kinase inhibitors as anti-cancer agents that target the interaction with Dbf4 by the fragment complementation and drug repositioning approach -
    [李岳倫] 期刊論文 2018-06-13 Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity -
    [許佳賢] 會議論文/會議摘要 2018-04-26 Generation of hanging drops with defined solution concentrations using a sliding hanging drop chip -
    [江運金] 期刊論文 2018-02 Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish -
    [杜鴻運] 期刊論文 2017-12 Genetic diversity of the Mycobacterium tuberculosis East African-Indian family in three tropical Asian countries -
    [許佳賢] 會議論文/會議摘要 2017-08-29 High-throughput formation and long-term culture of embryoid bodies using a microfluidic hanging drop chip -
    [杜鴻運] 期刊論文 2017-07-14 Combining molecular typing and spatial pattern analysis to identify areas of high tuberculosis transmission in a moderate-incidence county in Taiwan -
    [江運金] 會議論文/會議摘要 2017-07 Zebrafish nicastrin deficiency leads to a Tyrosinase-dependent depigmentation -
    [許佳賢] 期刊論文 2017-05 A novel compressive stress-based osteoarthritis-like chondrocyte system -
    [許佳賢] 期刊論文 2017-04-12 Development of a simple static microwell array with uniform cell seeding and a chemical concentration gradient -
    [許佳賢] 期刊論文 2017-02-02 Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus -
    [杜鴻運] 期刊論文 2017-01 Recombinant bacille Calmette–Guerin coexpressing Ag85b, CFP10, and interleukin-12 elicits effective protection against Mycobacterium tuberculosis -
    [許佳賢] 期刊論文 2016-12 C-phycocyanin alleviates osteoarthritic injury in chondrocytes stimulated with H2O2 and compressive stress -
    [許佳賢] 期刊論文 2016-12 Microfluidic tumor-mimicking in vitro cell culture methods -
    [許佳賢] 會議論文/會議摘要 2016-11-24 A microfluidic device for single cell isolation from rare samples -
    [許佳賢] 期刊論文 2016-10 Laminin modification subretinal bio-scaffold remodels retinal pigment epithelium-driven microenvironment in vitro and in vivo -
    [許佳賢] 期刊論文 2016-08-31 Continuous microfluidic assortment of interactive ligands (CMAIL) -
    [林名釗] 期刊論文 2016-08-02 Cardiac fibrosis in mouse expressing DsRed tetramers involves chronic autophagy and proteasome degradation insufficiency -
    [許佳賢] 期刊論文 2016-07-08 A High-throughput automated microfluidic platform for calcium imaging of taste sensing -
    [許佳賢] 期刊論文 2016-07-06 A PDMS-based microfluidic hanging drop chip for embryoid body formation -
    [劉滄梧] 期刊論文 2016-07 Characteristics of young lung cancer: Analysis of Taiwan's nationwide lung cancer registry focusing on epidermal growth factor receptor mutation and smoking status -
    [許佳賢] 期刊論文 2016-06-16 A microfluidic platform for high-throughput single-cell isolation and culture -
    [廖本揚] 期刊論文 2016-05 Proteins with highly evolvable domain architectures are non-essential but highly retained -
    [許佳賢] 期刊論文 2016-04-05 Enzyme-free dissociation of neurospheres by a microfluidic chip-based method -
    [許佳賢] 期刊論文 2016-01-26 Self-concentrating buoyant glass microbubbles for high sensitivity immunoassays -
    [杜鴻運] 期刊論文 2015-12-10 Draft genome sequence of mycobacterium tuberculosis clinical strain W06, a prevalent Beijing genotype isolated in Taiwan -
    [許佳賢] 期刊論文 2015-12 Fertilization of mouse gametes in vitro using a digital microfluidic system -
    [林名釗] 期刊論文 2015-10 Neonatal death and heart failure in mouse with transgenic HSP60 expression -
    [許佳賢] 期刊論文 2015-07 A microfluidic dual-well device for high-throughput single-cell capture and culture -
    [許佳賢] 會議論文/會議摘要 2015-07 Effects of culture medium and volume on preimplantation development of mouse embryos -
    [許佳賢] 會議論文/會議摘要 2015-07 Cell sorting in microfluidic systems using dielectrophoresis -
    [江運金] 期刊論文 2015-06-03 A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect -
    [許佳賢] 專利 2015-05-19 Microfluidic hanging drop chip -
    [許佳賢] 期刊論文 2015-03 Electronic hydroxyl radical microsensors based on the conductivity change of polyaniline -
    [許佳賢] 期刊論文 2015-03 Fast sorting of CD4+ T cells from whole blood using glass microbubbles -
    [許佳賢] 期刊論文 2015-03 Microwells support high-resolution time-lapse imaging and development of preimplanted mouse embryos -
    [邱英明] 期刊論文 2015-03 純機械式非酵素型神經球單細胞分離微流晶片 -
    [許佳賢] 會議論文/會議摘要 2015-01 In vitro dynamic fertilization by using EWOD device -
    [許佳賢] 會議論文/會議摘要 2014-10 Novel cholesterol sensor based on ultra-low detection limit hydrogen peroxide sensor -
    [許佳賢] 會議論文/會議摘要 2014-10 A novel ultra-low detection limit hydrogen peroxide sensor based on horseradish peroxidase immobilized polyaniline film -
    [許佳賢] 會議論文/會議摘要 2014-10 Measurement and modeling of M13 bacteriophages transport in conical-shaped nanopores -
    [許佳賢] 期刊論文 2014-09-15 Cost-effective and highly sensitive cholesterol microsensors with fast response based on the enzyme-induced conductivity change of polyaniline -
    [許佳賢] 專利 2014-07-11 微流體懸吊液珠晶片 -
    [林嬪嬪] 期刊論文 2014-06-13 TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways -
    [許佳賢] 期刊論文 2014-05-15 Realization of an ultra-sensitive hydrogen peroxide sensor with conductance change of horseradish peroxidase-immobilized polyaniline and investigation of the sensing mechanism -
    [江運金] 期刊論文 2014-04-08 New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens -
    [許佳賢] 期刊論文 2014-03 Investigation of C-terminal domain of SARS nucleocapsid protein - Duplex DNA interaction using transistors and binding-site models -
    [李岳倫] 期刊論文 2014-02 Structural basis for DNA-mediated allosteric regulation facilitated by the AAA(+) module of Lon protease -
    [許佳賢] 期刊論文 2013-11-28 Viscosity-dependent drain current noise of AlGaN/GaN high electron mobility transistor in polar liquids -
    [許佳賢] 期刊論文 2013-11 Single-cell enzyme-free dissociation of neurospheres using a microfluidic chip -
    [林名釗] 會議論文/會議摘要 2013-08 Transgenic expression of Heat Shock Protein 60 results in neonatal death and adult heart failure -
    [許佳賢] 期刊論文 2013-05 Human immunodeficiency virus drug development assisted with AlGaN/GaN high electron mobility transistors and binding-site models -
    [夏和雄(1996-2012)] 會議論文/會議摘要 2013-05 Concurrent chemoradiotherapy with cetuximab plus twice-weekly paclitaxel and cisplatin followed by esophagectomy for locally advanced esophageal squamous cell carcinoma -
    [許佳賢] 期刊論文 2013-03 AlGaN/GaN high electron mobility transistors for protein-peptide binding affinity study -
    [陳嘉祥(2009-2013)] 期刊論文 2012-08 Identification and characterization of three inherited genomic copy number variations associated with familial schizophrenia -
    [林名釗] 會議論文/會議摘要 2012-08 Transgenic expression of DsRed tetramers causes carditis and dilated heart failure -
    [林名釗] 期刊論文 2012-08 Ferritin-red fluorescent protein fusion reporter for magnetic resonance and optical imaging -
    [于重元] 期刊論文 2012-05 The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription -
    [陳立宗] 期刊論文 2011-12 Induction chemotherapy with gemcitabine, oxaliplatin, and 5-Fluorouracil/Leucovorin followed by concomitant chemoradiotherapy in patients with locally advanced pancreatic cancer: A Taiwan cooperative oncology group phase II study -
    [陳立宗] 期刊論文 2011-12 t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement -
    [江運金] 期刊論文 2011-12 Nitrite-Mediated S-Nitrosylation of Caspase-3 prevents hypoxia-induced endothelial barrier dysfunction -
    [林名釗] 會議論文/會議摘要 2011-10 An efficient voxel-driven system model for helical pinhole SPECT -
    [許佳賢] 會議論文/會議摘要 2011-10 Development of a microfluidic hanging droplet platform for 3D cell culture -
    [許佳賢] 會議論文/會議摘要 2011-10 A microfluidic device for sorting cancer cells based on cell motility -
    [姚晶(2001-2014)] 期刊論文 2011-07 Simple mobile single-sided NMR apparatus with a relatively homogeneous B0 distribution -
    [陳立宗] 期刊論文 2011-05 Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001 -
    [劉紹興] 會議論文/會議摘要 2011-01 The pilot study of specific biomarkers in health effects among engineered nanoparticles manufacturing workers -
    [李岳倫] 期刊論文 2010-12 Obtusilactone A and (-)-sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints -
    [林名釗] 期刊論文 2010-10 RU486-inducible recombination in the salivary glands of lactoferrin promoter-driven green fluorescent Cre transgenic mice -
    [林名釗] 期刊論文 2010-06 An additive poisson data modeling of attenuation map reconstruction from post-injection positron emission tomography transmission scan -
    [林名釗] 期刊論文 2010-04 Detection of experimentally induced pulmonary granuloma Inflammation in monocyte chemoattractant protein-1 reporter mice -
    [劉界元(2003-2010)] 期刊論文 2010-02-01 Modulation of human UMP/CMP kinase affects activation and cellular sensitivity of deoxycytidine analogs -
    [許佳賢] 會議論文/會議摘要 2010 Isolating cells from blood using buoyancy activated cell sorting (BACS) with glass microbubbles -
    [林名釗] 會議論文/會議摘要 2009-10-25 A voxel-driven system matrix design for multipinhole SPECT with overlapping projection -
    [林名釗] 期刊論文 2009-10 Noninvasive optical imaging for tracking gene delivery and recombination in tumor -
    [林名釗] 會議論文/會議摘要 2009-06 An accurate and efficient system model of iterative image reconstruction in high-resolution pinhole SPECT for small animal research -
    [林名釗] 會議論文/會議摘要 2009-05 Effect of geometric models on convergence rate in iterative PET image reconstructions -
    [陳立宗] 會議論文/會議摘要 2009-05 RAD001 (everolimus) suppresses growth of a gastric MALT lymphoma cell Line via downregulation of pAKT/mTOR and BAFF/NF-\#954;B signal transduction pathways -
    [其他] 期刊論文 2009-04-24 Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway -
    [林名釗] 會議論文/會議摘要 2008-10 On the convergence of iterative ordered-subset algorithms in small animal PET -
    [陳炯東] 期刊論文 2008-09 Human breast tumor cells express multimodal imaging reporter genes -
    [林名釗] 期刊論文 2008-07 Angiogenic evaluation of ginsenoside Rg(1) from Panax ginseng in fluorescent transgenic mice -
    [林名釗] 期刊論文 2008 An Investigation of geometric factor in interactive PET image reconstruction -
    [林名釗] 會議論文/會議摘要 2007-11 A unified segmentation method for CT image segmentation with contrast agent -
    [阮麗蓉(2000-2006)] 期刊論文 2006-11-01 The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression -
    [吳焜裕(2001-2008)] 期刊論文 2006-05 Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers -
    [陳立宗] 期刊論文 2006-03 Phase I-II trial of weekly gemcitabine plus high-dose 5-fluorouracil and leucovorin in advanced pancreatic cancer -
    [其他] 會議論文/會議摘要 2006-03 A voxel-based partial volume correction in nuclear medicine -
    [莊雙恩] 期刊論文 2006-01-06 A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation - Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus -
    [林名釗] 會議論文/會議摘要 2005-10 A row-action image reconstruction of short time frame for microPET dynamic study -
    [彭汪嘉康(1996-2007)] 期刊論文 2005-09-14 Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients -
    [其他] 會議論文/會議摘要 2005-03-28 Phase II study of weekly vinorelbine and 24-h infusion of high-dose 5-fluorouracil plus leucovorin as first-line treatment of advanced breast cancer -
    [劉界元(2003-2010)] 期刊論文 2005-03 Phosphorylation of cytidine, deoxycytidine, and their analog monophosphates by human UMP/CMP kinase is differentially regulated by ATP and magnesium -
    [彭汪嘉康(1996-2007)] 期刊論文 2005 Survival outcome of inoperable non-small cell lung cancer patients receiving conventional dose epirubicin and paclitaxel as first-line treatment -
    [其他] 期刊論文 2005 Phase II study of weekly paclitaxel and 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of recurrent or metastatic gastric cancer -
    [其他] 會議論文/會議摘要 2004-10 Finite aperture modeling in small animal pinhole SPECT Imaging -
    [阮麗蓉(2000-2006)] 期刊論文 2004-06-02 HCMV IE2-mediated inhibition of HAT activity downregulates p53 function -
    [其他] 期刊論文 2004-06 An investigation of block-sequential algorithms in statistical PET image reconstruction -
    [其他] 期刊論文 2004-05-04 Weekly gemcitabine plus 24-h infusion of high-dose 5-fluorouracil/leucovorin for locally advanced or metastatic carcinoma of the biliary tract -
    [彭汪嘉康(1996-2007)] 期刊論文 2003-06 Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma -
    [林名釗] 圖書 2003 Functional and molecular imaging using positron emission tomography -
    [莊雙恩] 期刊論文 2002-11 Induction of Epstein-Barr virus (EBV) reactivation in Raji cells by doxorubicin and cisplatin -
    [賴基銘(2004-2008)] 期刊論文 2000-02 Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis -
    [劉敏(1996-2007)] 期刊論文 1997-07 Weekly 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of advanced gastric cancers - An effective and low-toxic regimen for patients with poor general condition -

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