國家衛生研究院 NHRI:Item 3990099045/10004
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    题名: Warfarin and coumarin-like Murraya paniculata extract down-regulate EpCAM-mediated cell adhesion: Individual components versus mixture for studying botanical metastatic chemopreventives
    作者: Shao, JW;Zhou, SX;Jiang, Z;Chi, T;Ma, J;Kuo, ML;Lee, AYL;Jia, L
    贡献者: National Institute of Cancer Research
    摘要: We recently defined cancer metastatic chemoprevention as utilizing safe and effective molecules to comprehensively prevent the spark of activation-adhesion-extravasation-proliferation metastatic cascade caused by circulating tumor cells (CTCs). The strategy focuses on preventing the most important starting point of the cascade. We identified an extract from a well-known medical plant Murraya paniculata, which inhibited both embryonic implantation to human endometrium as traditionally-used for abortion and CTC adhesion to human endothelium. Here, we separated and characterized five coumarin-containing components (Z1-Z5) from the botanic extract. Flow cytometry revealed that within 1-100 mug/mL, Z3 and Z5 down-regulated EpCAM expression in human colon HCT116, whereas, Z1 and Z2 did oppositely. Warfarin and Z1-Z5 component mixture (CM) also down-regulated EpCAM expression. The down-regulation of EpCAM by Z3, Z5, CM and warfarin was confirmed by western blotting, and caused inhibition on adhesion of cancer cells to human endothelial cells. Rat coagulation study showed that warfarin prolonged prothrombin time, whereas, Z3 did not. The present studies revealed that, for the first time, warfarin and coumarin-like components Z3, Z5 and CM from Murraya paniculata could directly inhibit EpCAM-mediated cell-cell adhesion.
    日期: 2016-08-02
    關聯: Scientific Reports. 2016 Aug 2;6:Article number 30549.
    Link to: http://dx.doi.org/10.1038/srep30549
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000380632800001
    显示于类别:[李岳倫] 期刊論文

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