國家衛生研究院 NHRI:Item 3990099045/10009
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    题名: Beta1 integrin as a prognostic and predictive marker in triple-negative breast cancer
    其它题名: β1 integrin as a prognostic and predictive marker in triple-negative breast cancer
    作者: Yin, HL;Wu, CC;Lin, CH;Chai, CY;Hou, MF;Chang, SJ;Tsai, HP;Hung, WC;Pan, MR;Luo, CW
    贡献者: National Institute of Cancer Research
    摘要: Triple negative breast cancer (TNBC) displays higher risk of recurrence and distant metastasis. Due to absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), TNBC lacks clinically established targeted therapies. Therefore, understanding of the mechanism underlying the aggressive behaviors of TNBC is required for the design of individualized strategies and the elongation of overall survival duration. Here, we supported a positive correlation between beta1 integrin and malignant behaviors such as cell migration, invasion, and drug resistance. We found that silencing of beta1 integrin inhibited cell migration, invasion, and increased the sensitivity to anti-cancer drug. In contrast, activation of beta1 integrin increased cell migration, invasion, and decreased the sensitivity to anti-cancer drug. Furthermore, we found that silencing of beta1 integrin abolished Focal adhesion kinese (FAK) mediated cell survival. Overexpression of FAK could restore cisplatin-induced apoptosis in beta1 integrin-depleted cells. Consistent to in vitro data, beta1 integrin expression was also positively correlated with FAK (p = 0.031) in clinical tissue. More importantly, beta1 integrin expression was significantly correlated with patient outcome. In summary, our study indicated that beta1 integrin could regulate TNBC cells migration, invasion, drug sensitivity, and be a potential prognostic biomarker in TNBC patient survival.
    日期: 2016-09
    關聯: International Journal of Molecular Sciences. 2016 Sep;17(9):Article number 1432.
    Link to: http://dx.doi.org/10.3390/ijms17091432
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000385525500059
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85016089903
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