國家衛生研究院 NHRI:Item 3990099045/10015
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    题名: A novel application of E1A in combination therapy with EGFR-TKI treatment in breast cancer
    作者: Su, CM;Chang, TY;Hsu, HP;Lai, HH;Li, JN;Lyu, YJ;Kuo, KT;Huang, MT;Su, JL;Chen, PS
    贡献者: National Institute of Cancer Research
    摘要: Epidermal growth factor receptor (EGFR) is commonly overexpressed in breast cancer and is associated with poor clinical outcomes; however, an increasing number of patients have shown a poor effective response to EGFR tyrosine kinase inhibitors (EGFR-TKI). Here, we found that AXL expression was positively correlated with poor progression in breast cancer patients. Suppression of AXL by an anti-tumor protein, E1A, enhanced EGFR-TKI (gefitinib, erlotinib and lapatinib) sensitization, resulting in significant inhibition of tumor growth in breast cancer cells. Additionally, AXL overexpression dramatically impaired E1A-mediated EGFR-TKI sensitization. These findings show that downregulation of AXL expression by E1A contributes to sensitization to EGFE-TKI in breast cancer, suggesting that combinatorial therapy of AXL inhibitors or E1A gene therapy with EGFR-TKI may be a potential therapeutic strategy for treatment of breast cancer patients.
    日期: 2016-09
    關聯: Oncotarget. 2016 Sep;7(39):63924-63936.
    Link to: http://dx.doi.org/10.18632/oncotarget.11737
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000387167800087
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84993982792
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