國家衛生研究院 NHRI:Item 3990099045/10075
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    题名: Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-mCpG-Np95-Dnmt1 axis
    其它题名: Epigenetic Enhancement of the Post-replicative DNA Mismatch Repair of Mammalian Genomes by a Hemi-(m)CpG-Np95-Dnmt1 Axis
    作者: Wang, KY;Chen, CC;Tsai, SF;Shen, CJ
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: DNA methylation at C of CpG dyads (mCpG) in vertebrate genomes is essential for gene regulation, genome stability and development. We show in this study that proper functioning of post-replicative DNA mismatch repair (MMR) in mammalian cells relies on the presence of genomic mCpG, as well as on the maintenance DNA methyltransferase Dnmt1 independently of its catalytic activity. More importantly, high efficiency of mammalian MMR surveillance is achieved through a hemi-mCpG-Np95(Uhrf1)-Dnmt1 axis, in which the MMR surveillance complex(es) is recruited to post-replicative DNA by Dnmt1, requiring its interactions with MutSalpha, as well as with Np95 bound at the hemi-methylated CpG sites. Thus, efficiency of MMR surveillance over the mammalian genome in vivo is enhanced at the epigenetic level. This synergy endows vertebrate CpG methylation with a new biological significance and, consequently, an additional mechanism for the maintenance of vertebrate genome stability.
    日期: 2016-11-25
    關聯: Scientific Reports. 2016 Nov 25;6:Article number 37490.
    Link to: http://dx.doi.org/10.1038/srep37490
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000388481300001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84997514494
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