國家衛生研究院 NHRI:Item 3990099045/10106
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10106


    Title: Expressions of the CagA protein and CagA-signaling molecules predict H. pylori-dependence of early-stage gastric DLBCL
    Authors: Kuo, SH;Chen, LT;Lin, CW;Yeh, KH;Shun, CT;Tzeng, YS;Liou, JM;Wu, MS;Hsu, PN;Cheng, AL
    Contributors: National Institute of Cancer Research
    Abstract: We previously reported that early-stage gastric diffuse large B-cell lymphomas (DLBCLs), including DLBCLs with (DLBCL[MALT]) and without ('pure' DLBCL) the features of MALT lymphomas, can achieve long-term complete remission after frontline Helicobacter pylori (HP) eradication (HPE). We recently reported that expression of CagA and CagA-signaling molecules (p-SHP2 and p-ERK) is associated with the HP-dependence of gastric MALT lymphoma. However, the significance of CagA and CagA-signaling molecules in gastric DLBCL remains unexplored. The association between expression of CagA, p-SHP-2, and p-ERK in malignant B-cells and tumor response to HPE was evaluated in 63 patients with stage IE/IIE1 HP-positive gastric DLBCL who received HPE as frontline treatment. We detected CagA expression in 20 (47.6%) of 42 DLBCL(MALT) cases and in 13 (61.9%) of 21 'pure' DLBCL cases. CagA expression was higher in HP-dependent tumors than in HP-independent tumors (74.3% [26/35] versus 25.0% [7/28], P < .001). Patients with CagA expression responded to HPE quicker than those without expression (median time to complete remission, 4.0 months versus 5.0 months, P = .05). The expression of CagA was closely associated with p-SHP-2 (P < .001) and p-ERK (P = .002) expression. Combined CagA, p-SHP-2, and p-ERK expression showed an increased positive predictive value (81.8% versus 75.9%) and an increased specificity (84.0% versus 75.0%) for HP-dependence compared with CagA expression alone. Our results indicated that CagA and its signaling molecules can be detected in the malignant B-cells of gastric DLBCL, and the expression of these molecules is clinically and biologically associated with HP-dependence.
    Date: 2017-01
    Relation: Blood. 2017 Jan;129(2):188-198.
    Link to: http://dx.doi.org/10.1182/blood-2016-04-713719
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-4971&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000396528200015
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85018478922
    Appears in Collections:[Li-Tzong Chen] Periodical Articles

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