國家衛生研究院 NHRI:Item 3990099045/10155
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 908986      在线人数 : 965
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10155


    题名: Drosophila microRNA-34 impairs axon pruning of mushroom body gamma neurons by downregulating the expression of ecdysone receptor
    其它题名: Drosophila microRNA-34 impairs axon pruning of mushroom body γ neurons by downregulating the expression of ecdysone receptor
    作者: Lai, YW;Chu, SY;Wei, JY;Cheng, CY;Li, JC;Chen, PL;Chen, CH;Yu, HH
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: MicroRNA-34 (miR-34) is crucial for preventing chronic large-scale neurite degeneration in the aged brain of Drosophila melanogaster. Here we investigated the role of miR-34 in two other types of large-scale axon degeneration in Drosophila: axotomy-induced axon degeneration in olfactory sensory neurons (OSNs) and developmentally related axon pruning in mushroom body (MB) neurons. Ectopically overexpressed miR-34 did not inhibit axon degeneration in OSNs following axotomy, whereas ectopically overexpressed miR-34 in differentiated MB neurons impaired gamma axon pruning. Intriguingly, the miR-34-induced gamma axon pruning defect resulted from downregulating the expression of ecdysone receptor B1 (EcR-B1) in differentiated MB gamma neurons. Notably, the separate overexpression of EcR-B1 or a transforming growth factor- beta receptor Baboon, whose activation can upregulate the EcR-B1 expression, in MB neurons rescued the miR-34-induced gamma axon pruning phenotype. Future investigations of miR-34 targets that regulate the expression of EcR-B1 in MB gamma neurons are warranted to elucidate pathways that regulate axon pruning, and to provide insight into mechanisms that control large-scale axon degeneration in the nervous system.
    日期: 2016-12-23
    關聯: Scientific Reports. 2016 Dec 23;6:Article number 39141.
    Link to: http://dx.doi.org/10.1038/srep39141
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000390372700001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85007089967
    显示于类别:[陳俊宏] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB28008974.pdf2434KbAdobe PDF682检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈