國家衛生研究院 NHRI:Item 3990099045/10171
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    題名: Serum DHEA-S concentration correlates with clinical symptoms and neurocognitive function in patients with bipolar II disorder: A case-controlled study
    作者: Lee, SY;Wang, LJ;Chang, CH;Wu, CC;Chen, HL;Lin, SH;Chu, CL;Lu, T;Lu, RB
    貢獻者: Center for Neuropsychiatric Research
    摘要: Objectives Dysregulation of the neuroendocrine system including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and pregnenolone may play a role in the pathophysiology of bipolar II disorder (BP-II). The aims of the current study are to determine (a) the differences in DHEA, DHEA-S and pregnenolone in patients with BP-II and controls; and (b) the correlation of levels of the above hormones, cognitive function, and clinical symptoms. Methods Patients diagnosed with BP-II and healthy controls were recruited from psychiatric department. Blood samples were collected to measure the levels of DHEA, DHEA-S and pregnenolone in all participants, followed by assessment of cognitive function using the Brief Assessment of Cognition in Affective Disorders (BACA). Results A total of 32 patients BP-II and 30 healthy control subjects were recruited. The BP-II group was found with significantly elder age, fewer years of education, and lower BACA composite scores compared to the healthy controls. The level of DHEA-S was significantly associated with performance in BACA when controlling for age, gender, years of education and having BP-II (P = 0.018). The DHEA-S level was significantly correlated with mania score (r = − 0.498, P = 0.010). Conclusion Our findings support that serum level of DHEA-S may be a biomarker representing clinical manic symptoms and cognitive performance.
    日期: 2017-03-03
    關聯: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017 Mar 3;74:31-35.
    Link to: http://dx.doi.org/10.1016/j.pnpbp.2016.11.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0278-5846&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000392894700004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85002781942
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