國家衛生研究院 NHRI:Item 3990099045/10197
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 922182      線上人數 : 1359
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10197


    題名: Obesity, weight change, and chronic kidney disease in patients with Type 2 diabetes mellitus: A longitudinal study in Taiwan
    作者: Chung, HF;Al Mamun, A;Huang, MC;Long, KZ;Huang, YF;Shin, SJ;Hwang, SJ;Hsu, CC
    貢獻者: Division of Health Services and Preventive Medicine
    摘要: BACKGROUND: We investigated obesity and weight change in relation to risk of chronic kidney disease (CKD) in Asian patients with Type 2 diabetes using longitudinal data. METHODS: We recruited 1187 diabetic patients aged 30-70 years at baseline (2003-2005), and follow-up surveys were completed in 2008, 2009, and 2010. CKD was defined as having an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 ; body mass index (BMI; kg/m2 ) was categorised as normal (18.5-22.9), overweight (23-27.4), and obesity (>/=27.5); waist circumference (WC; cm) was categorised as normal and abdominal obesity (>/=80 for women, >/=90 for men). Weight/WC changes (%) were calculated between baseline and each follow-up survey. Generalized estimating equation models were used to estimate RR (95%CIs) of CKD. To estimate the risk for incident CKD, we examined the associations in patients without CKD at baseline (n = 881). RESULTS: During seven years of follow-up, obese BMI (RR:1.48, 1.08-2.04, p = 0.015) and excessive WC (RR:1.23, 1.00-1.52, p = 0.049) were associated with CKD after adjustment for covariates. Among CKD-free participants, patients who gained weight >10% (RR:1.43, 1.07-1.90, p = 0.015) and increased WC >15% (RR:1.37, 1.01-1.85, p = 0.045) had a higher risk of incident CKD compared with those who remained stable (+/-5%). The risks remained unchanged after adjusting for diabetic retinopathy and albuminuria. We also found a significant relationship between weight gain (per 1%) and eGFR decline (-0.04 mL/min/1.73 m2 /year, 95%CI:-0.07 to -0.02, p = 0.001). CONCLUSIONS: Diabetic patients with obese BMI and excessive central fat were more likely to have CKD. Large weight gain >10% and WC increase >15% independently predicted incident CKD.
    日期: 2016-12-15
    關聯: Journal of Diabetes. 2017 Nov;9(11):983-993.
    Link to: http://dx.doi.org/10.1111/1753-0407.12514
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1753-0393&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000413303300003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85013066201
    顯示於類別:[許志成] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB27976508.pdf481KbAdobe PDF237檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋