國家衛生研究院 NHRI:Item 3990099045/10205
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10205


    Title: Multipoint association mapping for longitudinal family data: An application to hypertension phenotypes
    Authors: Chiu, YF;Lee, CY;Hsu, FC
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: It is essential to develop adequate statistical methods to fully utilize information from longitudinal family studies. We extend our previous multipoint linkage disequilibrium approach-simultaneously accounting for correlations between markers and repeat measurements within subjects, and the correlations between subjects in families-to detect loci relevant to disease through gene-based analysis. Estimates of disease loci and their genetic effects along with their 95 % confidence intervals (or significance levels) are reported. Four different phenotypes-ever having hypertension at 4 visits, incidence of hypertension, hypertension status at baseline only, and hypertension status at 4 visits-are studied using the proposed approach. The efficiency of estimates of disease locus positions (inverse of standard error) improves when using the phenotypes from 4 visits rather than using baseline only.
    Date: 2016-10-18
    Relation: BMC Proceedings. 2016 Oct 18;10(Suppl. 7):Article number 54.
    Link to: http://dx.doi.org/10.1186/s12919-016-0049-2
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85015998165
    Appears in Collections:[Yen-Feng Chiu] Periodical Articles

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