國家衛生研究院 NHRI:Item 3990099045/10220

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Title:	Non-invasive photodynamic therapy in brain cancer by use of Tb3+-doped LaF3 nanoparticles in combination with photosensitizer through X-ray irradiation: A proof-of-concept study
Authors:	Chen, MH;Jenh, YJ;Wu, SK;Chen, YS;Hanagata, N;Lin, FH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed to a specific light wavelength produces the predominant cytotoxic agent, to destroy tumor cells. However, delivering an efficient light source to the brain tumor site is still a challenge. The light source should be delivered by placing external optical fibers into the brain at the time of surgical debulking of the tumor. Consequently, there exists the need for a minimally invasive treatment for brain cancer PDT. In this study, we investigated an attractive non-invasive option on glioma cell line by using Tb3+-doped LaF3 scintillating nanoparticles (LaF3:Tb) in combination with photosensitizer, meso-tetra(4-carboxyphenyl)porphyrin (MTCP), followed by activation with soft X-ray (80 kVp). Scintillating LaF3:Tb nanoparticles, with sizes of approximately 25 nm, were fabricated. The particles have a good dispersibility in aqueous solution and possess high biocompatibility. However, significant cytotoxicity was observed in the glioma cells while the LaF3:Tb nanoparticles with MTCP were exposed under X-ray irradiation. The study has demonstrated a proof of concept as a non-invasive way to treat brain cancer in the future.
Date:	2017-01-27
Relation:	Nanoscale Research Letters. 2017 Jan 27;12:Article number 62.
Link to:	http://dx.doi.org/10.1186/s11671-017-1840-3
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1931-7573&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000397571900002
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85010060303
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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