國家衛生研究院 NHRI:Item 3990099045/10232
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10232


    Title: Interplay between inflammation and stemness in cancer cells: The role of toll-like receptor signaling
    Authors: Yeh, DW;Huang, LR;Chen, YW;Huang, CYF;Chuang, TH
    Contributors: Immunology Research Center;Institute of Molecular and Genomic Medicine;National Institute of Cancer Research
    Abstract: Cancer stem cells (CSCs) are a small population of cancer cells that exhibit stemness. These cells contribute to cancer metastasis, treatment resistance, and relapse following therapy; therefore, they may cause malignancy and reduce the success of cancer treatment. Nuclear factor kappa B- (NF-B-) mediated inflammatory responses increase stemness in cancer cells, and CSCs constitutively exhibit higher NF-B activation, which in turn increases their stemness. These opposite effects form a positive feedback loop that further amplifies inflammation and stemness in cancer cells, thereby expanding CSC populations in the tumor. Toll-like receptors (TLRs) activate NF-B-mediated inflammatory responses when stimulated by carcinogenic microbes and endogenous molecules released from cells killed during cancer treatment. NF-B activation by extrinsic TLR ligands increases stemness in cancer cells. Moreover, it was recently shown that increased NF-B activity and inflammatory responses in CSCs may be caused by altered TLR signaling during the enrichment of stemness in cancer cells. Thus, the activation of TLR signaling by extrinsic and intrinsic factors drives a positive interplay between inflammation and stemness in cancer cells.
    Date: 2016-12-27
    Relation: Journal of Immunology Research. 2016 Dec 27;2016:Article number 4368101.
    Link to: http://dx.doi.org/10.1155/2016/4368101
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2314-8861&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000391977900001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85009351771
    Appears in Collections:[Tsung-Hsien Chuang] Periodical Articles
    [Li-Rung Huang] Periodical Articles
    [Ya-Wen Chen] Periodical Articles

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