國家衛生研究院 NHRI:Item 3990099045/10242
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    题名: Association between hyperuricemia and risk of deep vein thrombosis a nationwide population-based cohort study
    作者: Chiu, CC;Chen, YT;Hsu, CY;Chang, CC;Huang, CC;Leu, HB;Li, SY;Kuo, SC;Huang, PH;Chen, JW;Lin, SJ
    贡献者: Division of Infectious Diseases
    摘要: Background: Although the association of hyperuricemia and cardiovascular diseases is well established by previous research studies, the relationship between hyperuricemia and deep vein thrombosis (DVT) remains unclear. We conducted a nationwide longitudinal cohort study to investigate the relationship between hyperuricemia and DVT. Methods: We used the Taiwan National Health Insurance Research Database to identify patients with hyperuricemia diagnosed in Taiwan during 2000–2011, and we followed up these patients to determine the incidence of DVT among them. Hyperuricemia was defined as having at least one episode of gout attack requiring long-term treatment with uric acid-lowering agents. The association between hyperuricemia and DVT was analyzed by cox proportional hazard model. Results: The study cohort included 35,959 patients with hyperuricemia and 35,959 matched controls without hyperuricemia. The prevalence of comorbidities such as cardiovascular risk factors and risk factors for DVT were similar between the hyperuricemia and control groups. During the median follow-up of 7.5±3.6 years, the incidence rate of DVT was significantly higher in patients with hyperuricemia than that in control group (13.48 versus 9.77 per 104 person-years, p<0.001). Kaplan-Meier analysis revealed a tendency toward DVT development in hyperuricemia patients (log rank test, p<0.001). In a Cox model, patients with hyperuricemia were found to have a 1.38-fold (95% confidence interval [CI], 1.18 to 1.62, p<0.001) higher risk of developing DVT. Conclusions: Hyperuricemia is a significant risk factor for DVT, which provides new insights into pathogenesis and future therapeutic strategies.
    日期: 2016-08
    關聯: European Heart Journal. 2016 Aug;37(Suppl. 1):658-659.
    Link to: http://spo.escardio.org/SessionDetails.aspx?eevtid=1127&sessId=19171&subSessId=5516#.WKEPu2996po
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0195-668X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000383869503188
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