國家衛生研究院 NHRI:Item 3990099045/10246
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 908662      線上人數 : 1062
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10246


    題名: Genetic and functional analysis of EGR family genes in schizophrenia
    作者: Cheng, MC;Chuang, YA;Hsu, SH;Chen, CH
    貢獻者: Center for Neuropsychiatric Research
    摘要: Background: Early growth response genes (EGR1, 2, 3, and 4) encode a family of nuclear proteins that function as transcriptional regulators, and are involved in the regulation of synaptic plasticity, learning, and memory. Recent studies implicate that this gene family might be involved in the pathogenesis of schizophrenia. Methods: We conducted a genetic association analysis of 14 SNPs selected from the EGR1, 2, 3, and 4 genes in 564 patients with schizophrenia and 564 control subjects. We also conducted Western blot analysis and promoter activity assay to characterize the genetic association of the EGR gene family and schizophrenia. Results: We detected a significant over-representation of the C/C genotype of the rs9990(p=0.012) and the haplotype C-G-C of the EGR2 gene (p=0.015) in female schizophrenia. Further study showed that the mRNA levels of the EGR2 in the lymphoblastoid cell lines in female schizophrenia were significantly higher than that in female control subjects (p=0.002). In addition, we detected 4 SNPs (rs6747506, rs6718289, rs2229294, and rs3813226) of the EGR4 gene associated with male schizophrenia. Reporter gene assay of the haplotypes derived from two promoter SNPs (rs6747506 and rs6718289) showed that the haplotype T-A that was associated with male schizophrenia had significantly reduced promoter activity. No association of theEGR1 and 3 genes with schizophrenia was detected in this study. Discussion: Our data indicate that elevated expression of the EGR2 might be associated with the pathogenesis of schizophrenia in females, while reduced EGR4 expression might be associated with schizophrenia in males.
    日期: 2012-04
    關聯: Schizophrenia Research. 2012 Apr;136(Suppl. 1):S130.
    Link to: http://www.schres-journal.com/article/S0920-9964(12)70422-X/pdf
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0920-9964&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000209842101132
    顯示於類別:[陳嘉祥(2009-2013)] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000209842101132.pdf64KbAdobe PDF346檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋