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http://ir.nhri.org.tw/handle/3990099045/10272
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| Title: | Lower carotid flow velocities were associated with impaired cognitive function in a community-based elderly population |
| Authors: | Chuang, SY;Cheng, HM;Hwang, AC;Chen, LK;Chen, CH;Wang, PN |
| Contributors: | Division of Health Services and Preventive Medicine |
| Abstract: | Background: Carotid atherosclerosis (high intima-media thickness) was recognized to associate with stroke and cognitive function impairment. However, few studies investigated the association between carotid flow velocities and cognitive function. This study investigated the association between carotid flow velocities and cognitive function. Materials and methods: A total of 1684 seniors aged more than 65 years and without dementia was recruited for this aging study. All seniors were receiving the physical and mental examinations and drawing fasting blood sample for testing biochemical markers. The Mini-Mental State Examination (MMSE) was used to evaluate the global cognitive function. We classified the subjects with poor (MMSE<24), normal (MMSE: 24–27) and well (MMSE: ≥28) cognitive function. We used the linear regression and logistic regression to evaluate the association between carotid flow velocity and cognitive function. Multivariate linear regression and ordinal logistic regression were used to evaluate the association between carotid flow velocities and cognitive function. Results: Old age, women gender, low education and high systolic blood pressure, poor nutritional status, worse glucose control and inflammation status were associated with cognitive function. We also found that the peak systolic velocity (PSV) in common carotid artery and in internal carotid artery (ICA), and end-diastolic velocity in the ICA were positively associated with well cognitive function. The multivariate linear regression showed low systolic blood pressure (beta=-0.010, p-value=0.0145) and high CCA PSV (beta = 0.026, p-value=0.026, p-value = 0.014) were independently associated with higher MMSE, after controlling the age, sex, education, nutritional status and smoking. Compared to the referent group with higher CCA_PSV (≥68 cm/sec), the group with lowest CCA_PSV (<60 cm/sec) significantly increased 54% risk (OR=1.54; 95% CI: 1.14–2.08), and those seniors with middle CCA_PWV slightly increased 27% risk (OR=1.28; 95% CI: 0.998–1.63) for impaired cognitive function in the multivariate logistic regression. Conclusion: Low carotid flow velocities were significantly associated with impaired cognitive function and this relationship needs further prospective studies to confirm. |
| Date: | 2016-08 |
| Relation: | European Heart Journal. 2016 Aug;37(Suppl. 1):740. |
| Link to: | https://academic.oup.com/eurheartj/issue/37/suppl_1 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0195-668X&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000383869503459 |
| Appears in Collections: | [莊紹源] 會議論文/會議摘要
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| ISI000383869503459.pdf | | 143Kb | Adobe PDF | 760 | View/Open |
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