國家衛生研究院 NHRI:Item 3990099045/10273
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    题名: Serum uric acid levels and 20-year cardiovascular mortality: dual pathways of hemodynamics and renal function
    作者: Hsu, PF;Cheng, HM;Sung, SH;Chuang, SY;Yin, F;Lakatta, ED;Chou, P;Chen, CH
    贡献者: Division of Health Services and Preventive Medicine
    摘要: Background: The pathways between serum uric acid (UA) levels and future cardiovascular events remain unclear. We studied the contributions of conventional risk factors, hemodynamics, and renal function to the relationship between UA and cardiovascular mortality among generally healthy treatment naïve adults. Methods: A cohort of 624 normotensive and 633 untreated hypertensive Taiwanese participants (overall 669 men, aged 30–79 years) with complete demographic, cardiovascular, and biochemistry studies was drawn from a community-based survey. Fatal cardiovascular events within 20 years' follow-up (n=90) were ascertained with National Death Registry database. Results: UA correlated significantly with brachial systolic blood pressure (SBP) (r = 0.240, P<0.01) and estimated glomerular filtration rate (eGFR) (r=-0.423, P<0.01). In univariate Cox analysis, UA, SBP, and eGFR significantly predicted cardiovascular mortality [hazard ratios per 1SD and 95% confidence intervals: 1.37 (1.14–1.65), 2.26 (1.88–2.71), 0.42 (0.34–0.52), respectively]. SBP or eGFR but not UA was significantly predictive of cardiovascular mortality, in bi-variate and tri-variate analysis. In contrast, in a multivariate Cox model adjusted for age, sex, smoking, total cholesterol, high-density lipoprotein cholesterol, and fasting plasma glucose, UA was significantly independently predictive of cardiovascular mortality [1.26 (1.02–1.56)]. Conclusions: UA lost predictive power for cardiovascular mortality when either SBP or eGFR was added to the prediction models. Both hemodynamics and renal function are important pathways between the UA and cardiovascular mortality relationship.
    日期: 2016-08
    關聯: European Heart Journal. 2016 Aug;37(Suppl. 1):1333.
    Link to: https://academic.oup.com/eurheartj/issue/37/suppl_1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0195-668X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000383869506453
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