國家衛生研究院 NHRI:Item 3990099045/10288

NHRI > Institute of Molecular and Genomic Medicine > Isao Matsuura > Conference Papers/Meeting Abstract > Item 3990099045/10288

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Title:	Carcinogen 7,12-dimethylbenz a anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice
Authors:	Liu, ZX;Kundu, TR;Matsuura, L;Wang, GN;Lin, Y;Lou, YR;Barnard, NJ;Wang, XF;Huang, MT;Suh, N;Liu, F
Contributors:	Institute of Molecular and Genomic Medicine
Abstract:	Smad3 plays an important role in inhibiting cell proliferation and promoting apoptosis. Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. Here we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumorigenesis in a mouse model. Our findings provide strong support that Smad3 has important tumor suppressor function for breast cancer.
Date:	2016-07
Relation:	Cancer Research. 2016 Jul;76(Suppl. 14):Meeting Abstract 4070.
Link to:	http://dx.doi.org/10.1158/1538-7445.am2016-4070
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000389969803043
Appears in Collections:	[Isao Matsuura] Conference Papers/Meeting Abstract

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