國家衛生研究院 NHRI:Item 3990099045/10289
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    题名: Down-regulation of RASA1 is associated with poor prognosis in human hepatocellular carcinoma
    作者: Chen, YL;Huang, WC;Yao, HL;Chen, PM;Lin, PY;Feng, FY;Chu, PY
    贡献者: Institute of Molecular and Genomic Medicine;National Institute of Cancer Research
    摘要: BACKGROUND/AIM: RASA1 (p120RasGAP), encodes Ras GTPase-activating protein 1 and, is a potent tumor suppressor gene that is frequently inactivated in several human cancer types. However, its precise role in hepatocellular carcinoma (HCC) has been blurred. MATERIALS AND METHODS: We hypothesized that RASA1 plays a crucial role in tumor pathogenesis and progression of HCC. RASA1 expression levels were analyzed in 226 cases of HCC by immunohistochemistry. RESULTS: It was found that 38.68% (41/106) of the high-grade HCC samples and 54.17% (65/120) of the low-grade HCC samples expressed RASA1 protein. The difference between RASA1 expression in high-grade and low-grade HCC was statistically significant (p=0.02). Additionally, RASA1 high expression was inversely associated with larger tumor size (p<0.001). Although RASA1 is known as a tumor suppressor, its role in overall survival (OS) in HCC is unclear. Kaplan-Meier survival analysis showed that patients with low level of RASA1 expression correlated with a significantly poorer survival compared to those with high level of RASA1 expression. CONCLUSION: These data support that RASA1 could serve as an independent prognostic marker for HCC patients.
    日期: 2017-02
    關聯: Anticancer Research. 2017 Feb;37(2):781-785.
    Link to: http://dx.doi.org/10.21873/anticanres.11377
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-7005&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000396901200048
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85013631809
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