國家衛生研究院 NHRI:Item 3990099045/10296
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10296


    Title: Differential effects of stress and African ancestry on preterm birth and related traits among US born and immigrant Black mothers
    Authors: Tsai, HJ;Surkan, PJ;Yu, SM;Caruso, D;Hong, X;Bartell, TR;Wahl, AD;Sampankanpanich, C;Reily, A;Zuckerman, BS;Wang, XB
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Preterm birth (PTB, <37 weeks of gestation) is influenced by a wide range of environmental, genetic and psychosocial factors, and their interactions. However, the individual and joint effects of genetic factors and psychosocial stress on PTB have remained largely unexplored among U.S. born versus immigrant mothers.We studied 1121 African American women from the Boston Birth Cohort enrolled from 1998 to 2008. Regression-based analyses were performed to examine the individual and joint effects of genetic ancestry and stress (including lifetime stress [LS] and stress during pregnancy [PS]) on PTB and related traits among U.S. born and immigrant mothers.Significant associations between LS and PTB and related traits were found in the total study population and in immigrant mothers, including gestational age, birthweight, PTB, and spontaneous PTB; but no association was found in U.S. born mothers. Furthermore, significant joint associations of LS (or PS) and African ancestral proportion (AAP) on PTB were found in immigrant mothers, but not in U.S. born mothers.Although, overall, immigrant women had lower rates of PTB compared to U.S. born women, our study is one of the first to identify a subset of immigrant women could be at significantly increased risk of PTB and related outcomes if they have high AAP and are under high LS or PS. In light of the growing number of immigrant mothers in the U.S., our findings may have important clinical and public health implications.
    Date: 2017-02
    Relation: Medicine. 2017 Feb;96(5):Article numbere5899.
    Link to: http://dx.doi.org/10.1097/md.0000000000005899
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0025-7974&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000394253800018
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85013218780
    Appears in Collections:[Hui-Ju Tsai] Periodical Articles

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