國家衛生研究院 NHRI:Item 3990099045/10301
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10301


    Title: Prognostic significance of left ventricular mass index and renal function decline rate in Chronic Kidney Disease G3 and G4
    Authors: Huang, JC;Chen, SC;Tsai, YC;Kuo, IC;Chiu, YW;Chang, JM;Hwang, SJ;Chen, HC
    Contributors: Division of Geriatric Research
    Abstract: The effect of left ventricular mass index (LVMI) and estimated glomerular filtration rate (eGFR) decline rate on outcome prediction in patients with chronic kidney disease (CKD) remains unclear. We included 306 CKD G3 and G4 patients with LVMI assessed through echocardiography. Rapid decline in renal function was defined as the eGFR slope <-3 mL/min/1.73 m2/year. Patients were stratified into four groups using sex-specific median values of LVMI and rapid eGFR decline. The composite outcome was progression to maintenance dialysis or death. 32 patients had the composite outcome during a median follow-up of 2.7 years. In multivariate Cox analysis, compared with patients with non-rapid eGFR decline and lower LVMI, those with non-rapid eGFR decline and higher LVMI (hazard ratio [HR]: 5.908, 95% confidence interval [CI] = 1.304-26.780), rapid eGFR decline and lower LVMI (HR: 12.737, 95% CI = 2.297-70.636), and rapid eGFR decline and higher LVMI (HR: 15.249, 95% CI = 3.365-69.097) had an increased risk of progression to adverse outcomes. LVMI and eGFR decline synergistically effect the prognostic implications in CKD G3 and G4 patients.
    Date: 2017-02-14
    Relation: Scientific Reports. 2017 Feb 14;7:Article number 42578.
    Link to: http://dx.doi.org/10.1038/srep42578
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000393867100001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85012932378
    Appears in Collections:[Others] Periodical Articles

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