國家衛生研究院 NHRI:Item 3990099045/10343
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10343


    Title: Interrelations between mitochondrial DNA copy number and inflammation in older adults
    Authors: Wu, IC;CC, Lin;CS, Liu;CC, Hsu;CY, Chen;Hsiung, CA
    Contributors: Division of Biostatistics and Bioinformatics;Division of Geriatric Research
    Abstract: Background: Interplays between inflammation and mitochondrial biology are reported. Here, we examined the cross-sectional interrelationships of mitochondrial DNA copy number (mtDNACN) and inflammation and their interaction with physical functioning.Methods: A total of 1990 community-dwelling adults aged 65 years and older who were participating in the Healthy Aging Longitudinal Study in Taiwan underwent measurements of peripheral-blood leukocytes MtDNACN, multiple inflammatory markers, grip strength, and gait speed. Results: Principal components analysis revealed two inflammatory factors: factor 1 (high-sensitivity C-reactive protein [hs-CRP], white blood cell count, fibrinogen and interleukin-6 [IL-6]); factor 2 (tumor necrosis factor receptor 1, D-dimer and soluble interleukin-6 receptor). Participants with severe physical functioning impairment (low grip strength and gait speed) had higher (p < .05) levels of factor 1 and 2, but not mtDNACN, than did those with moderately impaired (low grip strength or gait speed) and normal physical functioning. MtDNACN was negatively related to factor 1 (r = −.221, p < .001) but not factor 2 (r = −.002, p = .938). Increased factor 1 was strongly associated with higher odds of physical functioning impairment in those with a low mtDNACN (adjusted odds ratios [OR] of moderate physical function impairment 1.21, 95% CI 1.01–1.44; adjusted OR of severe physical function impairment 1.52, 95% CI 1.25–1.85) but not in those with a high mtDNACN (p for interaction = .016). Conclusions: A low mtDNACN was associated with an inflammation exhibiting elevated hs-CRP, IL-6, fibrinogen, and white blood cell count, and strengthened the association of this inflammation with physical functioning impairment.
    Date: 2017-07
    Relation: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences.2017 Jul;72(7):937-944.
    Link to: https://doi.org/10.1093/gerona/glx033
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1079-5006&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000404880100012
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85021813832
    Appears in Collections:[I-Chien Wu] Periodical Articles
    [Ching-Yu Chen(2006-2010)] Periodical Articles
    [Chih-Cheng Hsu] Periodical Articles
    [Chao A. Hsiung] Periodical Articles

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