國家衛生研究院 NHRI:Item 3990099045/10391
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10391


    Title: Global DNA methylation and oxidative stress biomarkers in workers exposed to metal oxide nanoparticles
    Authors: Liou, SH;Wu, WT;Liao, HY;Chen, CY;Tsai, CY;Jung, WT;Lee, HL
    Contributors: National Institute of Environmental Health Sciences
    Abstract: This is the first study to assess global methylation, oxidative DNA damage, and lipid peroxidation in workers with occupational exposure to metal oxide nanomaterials (NMs). Urinary and white blood cell (WBC) 8-hydroxydeoxyguanosine (8-OHdG), and exhaled breath condensate (EBC) 8-isoprostane were measured as oxidative stress biomarkers. WBC global methylation was measured as an epigenetic alteration. Exposure to TiO2, SiO2, and indium tin oxide (ITO) resulted in significantly higher oxidative biomarkers such as urinary 8-OHdG and EBC 8-isoprostane. However, significantly higher WBC 8-OHdG and lower global methylation were only observed in ITO handling workers. Significant positive correlations were noted between WBC and urinary 8-OHdG (Spearman correlation r=0.256, p=0.003). Furthermore, a significant negative correlation was found between WBC 8-OHdG and global methylation (r=-0.272, p=0.002). These results suggest that exposure to metal oxide NMs may lead to global methylation, DNA oxidative damage, and lipid peroxidation.
    Date: 2017-06-05
    Relation: Journal of Hazardous Materials. 2017 Jun 05;331:329-335.
    Link to: http://dx.doi.org/10.1016/j.jhazmat.2017.02.042
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3894&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000398879800037
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=-85014378911
    Appears in Collections:[Saou-Hsing Liou] Periodical Articles
    [Wei-Te Wu] Periodical Articles

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