國家衛生研究院 NHRI:Item 3990099045/10392
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    題名: Intellectual evaluation of children exposed to phthalate-tainted products after the 2011 Taiwan phthalate episode
    作者: Huang, PC;Tsai, CH;Chen, CC;Wu, MT;Chen, ML;Wang, SL;Chen, BH;Lee, CC;Jaakkola, JJK;Wu, WC;Chen, MK;Hsiung, CA;Group, R
    貢獻者: National Institute of Environmental Health Sciences;Division of Biostatistics and Bioinformatics
    摘要: Introduction: Phthalate exposure may reduce intellectual development in young children. In 2011, numerous Taiwanese children had been reported to have consumed phthalate-tainted products. We investigated the effects of phthalate exposure on the intellectual development of these children after the 2011 Taiwan di-2-ethylhexyl phthalate (DEHP) episode. Methods: We recruited 204 children, aged 3-12 y, from 3 hospitals in Taiwan between 2012 and 2013. First morning urine samples were collected for analyzing 5 phthalate metabolites. We applied a Bayesian model to estimate the past DEHP exposure (estDEHPADD) of each participant before the 2011 DEHP episode. Demographic information, consumption of phthalate-tainted products, and maternal education, of each participant were obtained using a questionnaire. We used the Wechsler intelligence evaluation tools for assessing the children's and maternal intelligence quotient. Results and discussion: The median levels of mono-2-ethylhexyl phthalate, mono(2-ethyl-5-hydroxyhexyl) phthalate, mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-n-butyl phthalate, and mono-iso-butyl phthalate in the children were 9.97, 45.8, 32.2, 46.2, and 24.3 mu g/g creatinine, respectively. Using the aforementioned urinary phthalate metabolites, we found that the children's verbal comprehension index (N =98) was significantly negatively associated with urinary log(10) MEOHP (beta, 11.92; SE, 5.33; 95%CI, 22.52 1.33; P=0.028) and log(1) Sigma DBP metabolites (beta, -10.95; SE, 4.93; 95%CI, -20.74 similar to -1.16; P=0.029) after adjustment for age, gender, maternal IQ and education, passive smoking, estDEHPADD, active and passive smoking during pregnancy. Through a tolerable daily intake-based approach, we only found a significant negative association between past estimate DEHPADD and VIQ(>= 3- <6) in preschool children whereas no correlation was observed between current DEHP exposure and IQ(>= 3- <6) score with/without estimate DEHPADD adjustment It revealed that the effect of past high-DEHP exposure on verbal-related neurodevelopment of younger child are more sensitive. Conclusion: Our results are consistent with the hypothesis that exposure to DEHP and DnBP affects intellectual development in preschool and school-aged children, particularly their language learning or expression ability.
    日期: 2017-07
    關聯: Environmental Research. 2017 Jul;156:158-166.
    Link to: http://dx.doi.org/10.1016/j.envres.2017.03.016
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0013-9351&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000403735300021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85016165933
    顯示於類別:[王淑麗] 期刊論文
    [黃柏菁] 期刊論文
    [熊昭] 期刊論文
    [陳主智] 期刊論文

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