國家衛生研究院 NHRI:Item 3990099045/10404
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    题名: CagA and NFAT co-operatively participate in the lymphomagenesis of gastric MALT lymphoma
    作者: Kuo, SH;Tsai, HJ;Yeh, KH;Lin, CW;Zeng, YS;Wu, MS;Hsu, PN;Chen, LT;Cheng, AL
    贡献者: National Institute of Cancer Research
    摘要: Background: Previous studies revealed that in gastric epithelial cell, CagA can inhibit progression of the cell cycle through activation of nuclear factor of activated T-cell (NFAT) and NFAT-dependent genes, such as p21. We recently reported that CagA and its signaling molecules, p-SHP-2, p-ERK, and Bcl-xL were associated with H. pylori (HP) dependence of gastric mucosa-associated lymphoid tissue lymphoma (MALToma). In this study, we further assessed if CagA and NFAT co-operatively participate in the lymphomagenesis of gastric MALToma. Methods: HP strains were cultured from patients with HP-dependent gastric MALToma. We co-cultured gastric epithelial cell, MA-1 cell (t(14;18)(q32;q21)/IGH-MALT1-positive B-cell lymphoma), and Pfeiffer cell (diffuse large B-cell lymphoma) with HP strains and further evaluated the expression pattern of CagA, CagA-signaling molecules and NFATc1 using western blotting...
    日期: 2016-10
    關聯: Annals of Oncology. 2016 Oct;27(Suppl. 6):Meeting Abstract 933P.
    Link to: http://dx.doi.org/10.1093/annonc/mdw375.28
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0923-7534&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000393913000029
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85068307450
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