國家衛生研究院 NHRI:Item 3990099045/10406
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    题名: Effects of nanoliposomal irinotecan (nal-IRI;MM-398) +/- 5-fluorouracil and leucavorin (5-FU/LV) on quality of life (QoL) in patients (pts) with metastatic pancreatic adenocarcinoma (mPAC) previously treated with gemcitabine-based therapy: Results from t
    作者: Melisi, D;Melisi, D;Siveke, JT;Blanc, J;Von Hoff, DD;Wang-Gillam, A;Chen, L;Becker, C;Mamlouk, K;De Jong, F;Hubner, R
    贡献者: National Institute of Cancer Research
    摘要: Background: Here we report QoL results from the randomized, phase 3 NAPOLI-1 study of nal—IRI + 5—FU/LV vs 5-FU/LV alone in pts with mPDAC previously treated with gemcitabine-based therapy. Methods: QoL was assessed using the EORTC-QLQ-C30, which includes Functional, Symptom, and Global Health and QoL scales. Pts completed the questionnaire at treatment start, every 6 weeks (wks) and 30 days post-follow-up. Pts who were assessed at baseline and at ≥1 subsequent visit were included. Scores were reported in a 0–100 range after linear transformations were applied to raw scores. For each subscale, pt response was classified as improved (≥10% increase in scale of breadth at a post-baseline time point and remained above baseline for ≥6 wks), worsened (did not meet improvement criteria and died,...
    日期: 2016-09
    關聯: Annals of Oncology. 2016 Sep;27(Suppl. 4):Meeting Abstract B04.
    Link to: http://dx.doi.org/10.1093/annonc/mdw333.04
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0923-7534&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000393829200053
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