國家衛生研究院 NHRI:Item 3990099045/10423
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    题名: Oncogenic MCT-1 activation deregulates oxidative metabolism and promotes lung tumor progression and metastasis
    作者: Tseng, HY;Chen, YA;Jen, JY;Wang, YC;Hsu, HL
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Multiple copies in T-cell malignancy 1 (MCT-1) is involved in transcription regulation and translation initiation. We have identified that MCT-1 plays important roles in cell transformation and survival, catastrophic mitosis and genomic instability. Enhanced MCT-1 activity decreases p53 promoter function, protein stability and activity, thereby overexpressing MCT-1 further promotes tumorigenicity in a p53-null background. Enhanced MCT-1 activation induces SHCs (Src homology 2 domain containing transforming proteins) that transmit EGFR signaling to extracellular-regulated kinase (ERK) and AKT pathway. Here, we identify a novel carcinoma metabolism pathway involving MCT-1-YY1-EGFR-MnSOD axis which confers oxidative resistance, changes tumor microenvironments and promotes tumor development. Inhibiting this oncogenic pathway may be a novel clinical intervention approach to prevent tumor progression and metastasis.
    日期: 2017-03
    關聯: Cancer Research. 2017 Mar;77(Suppl. 6):Meeting Abstract A30.
    Link to: http://dx.doi.org/10.1158/1538-7445.Transcontrol16-A30
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000397860300022
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