國家衛生研究院 NHRI:Item 3990099045/10427
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10427


    Title: Ultrasound-responsive NIPAM-based hydrogels with tunable profile of controlled release of large molecules
    Authors: Wu, CH;Sun, MK;Shieh, J;Chen, CS;Huang, CW;Dai, CA;Chang, SW;Chen, WS;Young, TH
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: Episodic release of bioactive compounds plays an important role in biological systems. "On-demand" release systems which based on polymeric materials and activated by external stimuli may provide the necessary functionality. Here we describe an ultrasound-responsive hydrogel based on N-isopropylacrylamide (NIPAM) and N,N'-methylenebisacrylamide (MBAm), which is suitable for triggered release of two large molecules: bovine serum albumin (BSA, 66. kDa) and dextran (3-5. kDa). It is shown that the release amount of these two large molecules increased with increasing hydrogel temperature, and the application of ultrasound further increased the release. By simply adjusting the contents of NIPAM and MBAm, the difference of BSA release between the presence and absence of ultrasound could be adjusted from 2.7 to 84 folds. There was also a positive correlation between the ultrasound intensity and release amount. These properties made the NIPAM-based hydrogel a tunable platform for focal drug delivery.
    Date: 2018-02
    Relation: Ultrasonics. 2018 Feb;83:157-163.
    Link to: http://dx.doi.org/10.1016/j.ultras.2017.03.019
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0041-624X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000415887300019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85017343360
    Appears in Collections:[Others] Periodical Articles

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