國家衛生研究院 NHRI:Item 3990099045/10442
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    题名: Epigallocatechin-3-gallate reduces scavenger receptor a expression and foam cell formation in human macrophages
    作者: Chen, SJ;Kao, YH;Jing, L;Chuang, YP;Wu, WL;Liu, ST;Huang, SM;Lai, JH;Ho, LJ;Tsai, MC;Lin, CS
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Foam cells are formed when macrophages imbibe low-density lipoprotein (LDL) through scavenger receptors. Here we examined how epigallocatechin-3-gallate (EGCG) influences foam cell formation. We found that EGCG dose-dependently reduced oxidized LDL (oxLDL) uptake in THP-1 (10 muM, 20.0 +/- 0.50, p < 0.05) and primary macrophages (134.6 +/- 15.6, p < 0.05) and reduced intracellular cholesterol content in these cells, respectively (10 muM, 32.6 +/- 0.14, p < 0.05; 31.7 +/- 1.26, p < 0.05). EGCG treatment decreased scavenger receptor A expression, but not the expression of CD36 or of reverse cholesterol transporters. Moreover, EGCG stimulated translocation of the p50 and p65 subunits of NF-kappaB and enhanced NF-kappaB DNA-binding activity, thus suppressing SR-A promoter activity. EGCG's suppression of SR-A expression was blocked by the NF-kappaB inhibitor Bay. The present findings suggest that EGCG regulates NF-kappaB activity and thus suppresses SR-A expression, oxLDL uptake, and foam cell formation.
    日期: 2017-04-19
    關聯: Journal of Agricultural and Food Chemistry. 2017 Apr 19;65(15):3141-3150.
    Link to: http://dx.doi.org/10.1021/acs.jafc.6b05832
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-8561&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000399966300008
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85017644690
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