國家衛生研究院 NHRI:Item 3990099045/10443
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    题名: Glucose-sensitive self-healing hydrogel as sacrificial materials to fabricate vascularized constructs
    作者: Tseng, TC;Hsieh, FY;Theato, P;Wei, Y;Hsu, SH
    贡献者: Institute of Cellular and Systems Medicine
    摘要: A major challenge in tissue engineering is the lack of proper vascularization. Although various approaches have been used to build vascular network in a tissue engineering construct, there remain some drawbacks. Herein, a glucose-sensitive self-healing hydrogel are employed as sacrificial materials to fabricate branched tubular channels within a construct. The hydrogel composes of mainly reversibly crosslinked poly(ethylene glycol) diacrylate and dithiothreitol with borax as the glucose-sensitive motif. The hydrogel is injectable and mechanically strong after injection. Moreover, it can be rapidly removed by immersion in the cell culture medium. To show the feasibility in building a vascularized tissue construct, the designed branching vascular patterns of the glucose-sensitive hydrogel are extruded and embedded in a non glucose-sensitive hydrogel containing neural stem cells. Vascular endothelial cells seeded in the lumen of the channels by perfusion can line the channel wall and migrate into the non-sacrificial hydrogel after 3 days. In long-term ( approximately 14 days), the endothelial cells form capillary-like structure (vascular network) while neural stem cells form neurosphere-like structure (neural development) in the construct, revealing the morphology of "a vascularized neural tissue". The novel sacrificial materials can create complicated but easily removable structure for building a vascularized tissue construct particularly a neurovascular unit.
    日期: 2017-04-09
    關聯: Biomaterials. 2017 Apr 09;133:20-28.
    Link to: http://dx.doi.org/10.1016/j.biomaterials.2017.04.008
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0142-9612&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000401716700003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85017456428
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