國家衛生研究院 NHRI:Item 3990099045/10445
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12189/12972 (94%)
造访人次 : 955292      在线人数 : 656
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10445


    题名: A novel biodegradable self-healing hydrogel to induce blood capillary formation
    作者: Hsieh, FY;Tao, L;Wei, Y;Hsu, SH
    贡献者: Institute of Cellular and Systems Medicine
    摘要: A major challenge in tissue engineering is to generate a functional microvasculature that ensures proper blood perfusion and connection with surrounding tissues. Strategies such as the incorporation of growth factors have been proposed to induce the growth of new blood vessels into engineered tissue, but limitations remain. Herein a novel chitosan-fibrin (CF)-based self-healing hydrogel with a modulus of similar to 1.2 kPa was developed. The self-healing hydrogel was found to be injectable and to degrade similar to 70% in 2 weeks. Vascular endothelial cells seeded in the CF hydrogel were able to form capillary- like structures. Moreover, the injection of the CF hydrogel alone promoted angiogenesis in the perivitelline space of zebrafish and rescued the blood circulation in ischemic hindlimbs of mice. The excellent self- healing and angiogenic capacities of the hydrogel may be associated with the formation of an interpenetrating polymer network structure between chitosan and fibrin. This unique self-healing hydrogel offers new possibilities for future applications to vascular repair.
    日期: 2017-03
    關聯: Npg Asia Materials. 2017 Mar;9:Article number e363.
    Link to: http://dx.doi.org/10.1038/am.2017.23
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1884-4049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000397296800011
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85038386474
    显示于类别:[徐善慧] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000397296800011.pdf3033KbAdobe PDF348检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈