國家衛生研究院 NHRI:Item 3990099045/10453
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    题名: Improving neurorepair in stroke brain through endogenous neurogenesis-enhancing drugs
    作者: Wu, KJ;Yu, S;Lee, JY;Hoffer, B;Wang, Y
    贡献者: Center for Neuropsychiatric Research
    摘要: Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone(SVZ) of adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes which occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs, and review the general status of stroke therapeutics in evaluating the field of pharmacotherapy for stroke.
    日期: 2017-09
    關聯: Cell Transplantation. 2017 Sep;26(9):1596-1600.
    Link to: http://dx.doi.org/10.1177/0963689717721230
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0963-6897&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000414907000012
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85034056740
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