國家衛生研究院 NHRI:Item 3990099045/10473
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10473


    Title: Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: Results from Taiwan Stroke Registry
    Authors: Chen, YW;Li, CH;Yang, CD;Liu, CH;Chen, CH;Sheu, JJ;Lin, SK;Chen, AC;Chen, PK;Chen, PL;Yeh, CH;Chen, JR;Hsiao, YJ;Lin, CH;Hsu, SP;Chen, TS;Sung, SF;Yu, SC;Muo, CH;Wen, CP;Sung, FC;Jeng, JS;Hsu, CY;Investigators, Taiwan Stroke Registry
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low cholesterol levels may have association with intracerebral hemorrhage (ICH) severity at admission and 3-month outcomes. This study used data obtained from a multi-center stroke registry program in Taiwan. We categorized acute spontaneous ICH patients, based on their baseline levels of total cholesterol (TC) measured at admission, into 3 groups with <160, 160-200 and >200 mg/dL of TC. We evaluated risk of having initial stroke severity, with National Institutes of Health Stroke Scale (NIHSS) >15 and unfavorable outcomes (modified Rankin Scale [mRS] score >2, 3-month mortality) after ICH by the TC group. A total of 2444 ICH patients (mean age 62.5+/-14.2 years; 64.2% men) were included in this study and 854 (34.9%) of them had baseline TC <160 mg/dL. Patients with TC <160 mg/dL presented more often severe neurological deficit (NIHSS >15), with an adjusted odds ratio [aOR] of 1.80; 95% confidence interval [CI], 1.41-2.30), and 3-month mRS >2 (aOR, 1.41; 95% CI, 1.11-1.78) using patients with TC >200 mg/dL as reference. Those with TC >160 mg/dL and body mass index (BMI) <22 kg/m2 had higher risk of 3-month mortality (aOR 3.94, 95% CI 1.76-8.80). Prior use of lipid-lowering drugs (2.8% of the ICH population) was not associated with initial severity and 3-month outcomes. A total cholesterol level lower than 160 mg/dL was common in patients with acute ICH and was associated with greater neurological severity on presentation and poor 3-month outcomes, especially with lower BMI.
    Date: 2017-04-19
    Relation: PLoS ONE. 2017 Apr 19;12(4):Article number e0171379.
    Link to: http://dx.doi.org/10.1371/journal.pone.0171379
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000399875600004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85017666212
    Appears in Collections:[Chi-Pang Wen(2001-2010)] Periodical Articles

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