國家衛生研究院 NHRI:Item 3990099045/10509
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    題名: Prenatal and childhood exposure to phthalate diesters and sex steroid hormones in 2-, 5-, 8-, and 11-year-old children: A pilot study of the Taiwan Maternal and Infant Cohort Study
    作者: Wen, HJ;Sie, L;Su, PH;Chuang, CJ;Chen, HY;Sun, CW;Huang, LH;Hsiung, CA;Julie Wang, SL
    貢獻者: National Institute of Environmental Health Sciences;Division of Biostatistics and Bioinformatics
    摘要: BACKGROUND: Phthalate diesters are commonly used and have been well established as environmental endocrine disruptors. However, few studies have examined their effects on sex steroid hormones in children. We followed children over time to examine the association between pre- and post-natal phthalate exposure and sex steroid hormone levels at 2, 5, 8, and 11 years of age. METHODS: We recruited 430 pregnant women from central Taiwan from 2000 to 2001 and assessed their children at birth, 2, 5, 8, and 11 years of age. We studies children with at least one measurement for both phthalate and hormone levels during each any of the follow-up time point (n = 193). Estradiol, free testosterone, testosterone, and progesterone were measured from venous blood. Three monoesters of di-2-ethylhexyl phthalate (DEHP), mono-benzyl phthalate, mono-n-butyl phthalate, mono-ethyl phthalate, and mono-methyl phthalate were measured in maternal urine collected during the 3rd trimester and child urine collected at each follow-up point. The sum of mono-2-ethylhexyl phthalate ( summation operatorMEHP) was calculated by summing the concentrations of the three DEHP monoesters. Generalized estimating equation regression analysis with repeated measures was used to estimate associations between phthalate metabolites and hormone levels. RESULTS: After adjustment for potential confounders, maternal summation operatorMEHP level was associated with decreased levels of progesterone in girls (beta = -0.309 p = 0.001). The child summation operatorMEHP concentration was associated with decreased levels of progesterone for girls (beta = -0.194, p = 0.003) and with decreased levels of free testosterone for boys (beta = -0.124, p = 0.004). CONCLUSIONS: Early-life DEHP exposure may alter sex steroid hormones of children over time, which may pose potential reproductive health risks.
    日期: 2017-11
    關聯: Journal of Epidemiology. 2017 Nov;27(11):516-523.
    Link to: http://dx.doi.org/10.1016/j.je.2016.10.009
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0917-5040&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000411698200003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85030553454
    顯示於類別:[王淑麗] 期刊論文
    [熊昭] 期刊論文
    [温慧茹] 期刊論文

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