國家衛生研究院 NHRI:Item 3990099045/10521
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10521


    Title: The occurrence of hepatocellular carcinoma in different risk stratifications of clinically noncirrhotic nonalcoholic fatty liver disease
    Other Titles: HCC occurrence in non-cirrhotic NAFLD
    Authors: Lee, TY;Wu, JC;Yu, SH;Lin, JT;Wu, MS;Wu, CY
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: Non-alcoholic fatty liver disease (NAFLD) may be a cause of hepatocellular carcinoma (HCC), but its high prevalence challenges current surveillance strategies. We aimed to evaluate HCC incidences in different risk stratifications for non-cirrhotic NAFLD. Using Taiwan's National Health Insurance Research Database, we located 31,571 patients with NAFLD between the years 1998 and 2012. After excluding other causes of hepatitis, underlying cirrhosis, or malignancy, 18,080 patients were recruited for final analysis. Cumulative incidences of HCC were analyzed after adjusting for competing mortality. With a median follow-up duration of 6.32 years in the study cohort, the 10-year cumulative incidence of HCC was 2.73% (95% confidence interval [CI]: 1.69-3.76%). Hepatoprotectant was used as a surrogate marker for elevated serum alanine transaminase (ALT). After adjusting for age, gender, hypertension, hypercholesterolemia, diabetes mellitus, gout, statin use, metformin use, and aspirin use, elevated ALT was independently associated with an increased HCC risk (hazard ratio [HR] 6.80, 95% CI: 3.00-15.42; P< 0.001). Multivariate stratified analysis verified this association in all subgroups (HR> 1.0). Moreover, increased age (HR 1.08 per year, 95% CI: 1.05-1.11) and statin use (HR 0.29, 95% CI: 0.12-0.68) were also identified as independent risk factors. The 10-year cumulative HCC incidence was highest in older (age >55 years) patients with ALT elevation (12.41%, 95% CI: 5.99-18.83%), but lowest in younger patients without ALT elevation (0.36%, 95% CI: 0-1.08%). The incidence of HCC was relatively low in patients with clinically non-cirrhotic NAFLD, however HCC risk was significantly increased in older patients experiencing an elevated serum ALT.
    Date: 2017-10
    Relation: International Journal of Cancer. 2017 Oct;141(7):1307-1314.
    Link to: http://dx.doi.org/10.1002/ijc.30784
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0020-7136&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000406977600003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85021732290
    Appears in Collections:[Jaw-Town Lin] Periodical Articles

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