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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/10543
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| Title: | High fat diet induces mitochondria stress and impairs myelin structure in rat hypothalamus |
| Authors: | Huang, HT;Hsien, HH;Wu, HT;Tsai, SF;Huang, HY;Kuo, YM;Chen, PS;Yang, CS;Tzeng, SF |
| Contributors: | Institute of Biomedical Engineering and Nanomedicine |
| Abstract: | Obesity-induced central mild inflammation and metabolic control in the hypothalamus have been well documented. Gliosis, a reactive change of astrocytes and microglia, is observed in the hypothalamus of obese rodents and humans. However, the reaction of oligodendrocytes (OLGs), a CNS myelin producing glia population, in the hypothalamus of obese individuals is poorly known. Using high-fat diet (HFD)-fed mouse model, we found that Iba1+ microglia in arcuate nucleus (ARC) and median eminence (ME) in the hypothalamus of HFD-fed mice displayed an amoeboid hypertrophic form. Interestingly, we detected an increase in the protein level of IL-27, a pleiotropic cytokine that has been recently shown to inhibit the severity of experimental autoimmune encephalomyelitis. Through comparative microRNA microarray, we observed an increase in a group of microRNAs in the hypothalamus at 3 month post HFD feeding. Among these microRNAs, we confirmed that let-7f, a regulator of brain development and glucose metabolism, was increased in the hypothalamus after HFD feeding for 4 months. Moreover, the results from transmission electron microscopy (TEM) analysis indicated that fragmented or hyperfused mitochondria was observed in the hypothalamus of HFD-fed mice. The disturbed structure of myelin in the hypothalamus of HFD-fed mice was also detected by TEM. Based on these observations, we suggest that HFD-induced mild inflammation and changes in mitochondrial functions might impair metabolism homeostasis in OLGs, and cause an injury in myelin microstructure. |
| Date: | 2017-06 |
| Relation: | Glia. 2017 Jun;65(Suppl.):E207. |
| Link to: | http://dx.doi.org/10.1002/glia.23157 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0894-1491&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000403071700317 |
| Appears in Collections: | [楊重熙] 會議論文/會議摘要
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| ISI000403071700317.pdf | | 69Kb | Adobe PDF | 342 | View/Open |
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