國家衛生研究院 NHRI:Item 3990099045/10549
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 912963      線上人數 : 1167
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10549


    題名: Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth
    作者: Hong, XM;Hao, K;Ji, HK;Peng, SE;Sherwood, B;Di Narzo, A;Tsai, HJ;Liu, X;Burd, I;Wang, GY;Ji, YL;Caruso, D;Mao, GY;Bartell, TR;Zhang, ZY;Pearson, C;Heffner, L;Cerda, S;Beaty, TH;Fallin, MD;Lee-Parritz, A;Zuckerman, B;Weeks, DE;Wang, X
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: Preterm birth (PTB) contributes significantly to infant mortality and morbidity with lifelong impact. Few robust genetic factors of PTB have been identified. Such 'missing heritability' may be partly due to gene x environment interactions (G x E), which is largely unexplored. Here we conduct genome-wide G x E analyses of PTB in 1,733 African-American women (698 mothers of PTB; 1,035 of term birth) from the Boston Birth Cohort. We show that maternal COL24A1 variants have a significant genome-wide interaction with maternal pre-pregnancy overweight/obesity on PTB risk, with rs11161721 (PG x E=1.8 x 10-8; empirical PG x E=1.2 x 10-8) as the top hit. This interaction is replicated in African-American mothers (PG x E=0.01) from an independent cohort and in meta-analysis (PG x E=3.6 x 10-9), but is not replicated in Caucasians. In adipose tissue, rs11161721 is significantly associated with altered COL24A1 expression. Our findings may provide new insight into the aetiology of PTB and improve our ability to predict and prevent PTB.
    日期: 2017-06-09
    關聯: Nature Communications. 2017 Jun 09;8:Article number 15608.
    Link to: http://dx.doi.org/10.1038/ncomms15608
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000402962700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85040540725
    顯示於類別:[蔡慧如] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB28598419.pdf611KbAdobe PDF367檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋