國家衛生研究院 NHRI:Item 3990099045/10582
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 911816      線上人數 : 996
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10582


    題名: The role of consolidation chemoradiotherapy in Locally Advanced Pancreatic Cancer receiving chemotherapy: An updated systematic review and meta-analysis
    作者: Chang, JS;Chiu, YF;Yu, JC;Chen, LT;Ch'ang, HJ
    貢獻者: National Institute of Cancer Research;Division of Biostatistics and Bioinformatics
    摘要: Purpose: The role of consolidation chemoradiation (CCRT) after systemic chemotherapy in locally advanced pancreatic cancer (LAPC) is still controversial. We aim to evaluate the effectiveness of CCRT in LAPC using systematic review and meta-analysis of prospective studies. Materials and Methods: Prospective clinical trials of LAPC receiving chemotherapy with or without subsequent CCRT were included in the analysis. We systematically searched in PubMed, Medline, Embase, Web of Science. The primary outcome of interest was one-year survival. Secondary endpoints were median overall survival, progression-free survival, toxicity, and resection rate. Results: Forty-one studies with forty-nine study arms were included with a total of 1,018 patients receiving CCRT after induction chemotherapy (ICT) and 954 patients receiving chemotherapy alone. CCRT after ICT did not improve one-year survival significantly in LAPC patients compared with chemotherapy alone (58% vs 52%). ICT lasted for at least three months revealed significantly improved survival of additional CCRT to LAPC patients compared to chemotherapy alone (65% vs 52%). A marginal survival benefit of consolidation CCRT was noted in studies using maintenance chemotherapy (59% vs 52%), and fluorouracil-based CCRT (64% vs 52%), as well as in studies conducted after the 2010 (64% vs 55%). Conclusions: The survival benefit of ICT+CCRT over chemotherapy alone in treating LAPC was noted when ICT lasted for at least three months. Fluorouracil-based CCRT, and maintenance chemotherapy were associated with improved clinical outcomes.
    日期: 2018-04
    關聯: Cancer Research and Treatment. 2018 Apr;50(2):562-574.
    Link to: http://dx.doi.org/10.4143/crt.2017.105
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1598-2998&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000429484900025
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85044948952
    顯示於類別:[常慧如] 期刊論文
    [陳立宗] 期刊論文
    [張書銘] 期刊論文
    [邱燕楓] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB28602054.pdf770KbAdobe PDF328檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋