國家衛生研究院 NHRI:Item 3990099045/10638

NHRI > National Institute of Infectious Diseases and Vaccinology > Horng-Yunn Dou > Periodical Articles > Item 3990099045/10638

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10638

Title:	Combining molecular typing and spatial pattern analysis to identify areas of high tuberculosis transmission in a moderate-incidence county in Taiwan
Authors:	Chen, YY;Chang, JR;Wu, CD;Yeh, YP;Yang, SJ;Hsu, CH;Lin, MC;Tsai, CF;Lin, MS;Su, IJ;Dou, HY
Contributors:	Division of Infectious Diseases
Abstract:	In total, 303 randomly selected clinical Mycobacterium tuberculosis (MTB) isolates from 303 patients (collected January to December 2012) in central Taiwan were examined. The major lineages found were Beijing (N = 114, 37.62%), Haarlem (N = 76, 25.08%) and East African-Indian (EAI) (N = 42, 13.86%). Notably, younger persons (</=30 years old) were 6.58 times more likely to be infected with a Beijing genotype compared to older persons (>70 years) (p < 0.05). Combining molecular typing methods and geographical information system (GIS) analysis, we uncovered a twofold higher incidence of Beijing strains in a hotspot area (33%) compared to non-hotspot areas (17%). By 24 MIRU-VNTR typing, persons in clustered groups were 1.96 times more likely to be infected with a Beijing strain compared with non-clustered persons, suggesting recent spread and emergence of MTB. Finally, we observed a trend in which TB incidence increased as the density/concentration of analyzed environmental factors increased, suggesting that environmental factors are associated with TB transmission; however, only population density was found to be significantly associated with increased risk of TB (p < 0.05). Molecular typing methods combined with spatial analysis suggest possible TB transmission. Early intervention to interrupt transmission may be most effective if targeted to hot zones of TB.
Date:	2017-07-14
Relation:	Scientific Reports. 2017 Jul 14;7:Article number 5394.
Link to:	http://dx.doi.org/10.1038/s41598-017-05674-6
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000405464200031
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85024386369
Appears in Collections:	[Horng-Yunn Dou] Periodical Articles [Ih-Jen Su(2002-2015)] Periodical Articles

Files in This Item:

File	Description	Size	Format
PUB28710410.pdf		2929Kb	Adobe PDF	506	View/Open

Loading...