國家衛生研究院 NHRI:Item 3990099045/10651
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    題名: Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium
    作者: Kawakita, D;Amy Lee, YC;Turati, F;Parpinel, M;Decarli, A;Serraino, D;Matsuo, K;Olshan, AF;Zevallos, JP;Winn, DM;Moysich, K;Zhang, ZF;Morgenstern, H;Levi, F;Kelsey, K;McClean, M;Bosetti, C;Garavello, W;Schantz, S;Yu, GP;Boffetta, P;Chuang, SC;Hashibe, M;Ferraroni, M;La Vecchia, C;Edefonti, V
    貢獻者: Division of Health Policy Translation
    摘要: The possible role of dietary fiber in the etiology of head and neck cancers (HNCs) is unclear. We used individual-level pooled data from 10 case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th vs. 1st quintile category = 0.49, 95% CI: 0.40-0.59; p for trend <0.001) and with laryngeal cancer (OR = 0.66, 95% CI: 0.54-0.82, p for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral and pharyngeal cancer combined. Nonetheless, inverse associations were consistently observed for the subsites of oral and pharyngeal cancers and within most strata of the considered covariates, for both cancer sites. Our findings from a multicenter large-scale pooled analysis suggest that, although in the presence of between-study heterogeneity, a greater intake of fiber may lower HNC risk.
    日期: 2017-11
    關聯: International Journal of Cancer. 2017 Nov;141(9):1811-1821.
    Link to: http://dx.doi.org/10.1002/ijc.30886
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0020-7136&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000408973500011
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85026358989
    顯示於類別:[莊淑鈞] 期刊論文

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