國家衛生研究院 NHRI:Item 3990099045/10682

NHRI > National Institute of Infectious Diseases and Vaccinology > Guann-Yi Yu > Periodical Articles > Item 3990099045/10682

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10682

Title:	Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma
Authors:	Wu, MS;Wang, CH;Tseng, FC;Yang, HJ;Lo, YC;Kuo, YP;Tsai, DJ;Tsai, WT;Yu, GY
Contributors:	National Institute of Infectious Diseases and Vaccinology
Abstract:	Background: The role of interleukin (IL) 17A in chronic liver diseases had been extensively studied, but the function of IL-17F, which shares a high degree of homology with IL-17A, in the progression of chronic hepatic diseases is poorly understood. The aim of the study was to evaluate the association between IL-17F and liver diseases including, fibrosis and hepatocellular carcinoma (HCC). Methods: Hepatic tumor samples from both hepatitis C virus (HCV) positive and negative patients (without HBV and HCV, NBNC) were examined with quantitative PCR and immunohistochemistry staining for inflammatory cytokine genes expression. In addition, 250 HCV patients naive for interferon treatment were also subjected to enzyme-linked immunosorbent Assay (ELISA) for their serum cytokine concentrations. Results: Serum IL-17F concentrations were significantly elevated in HCV patients with severe fibrosis stages. In accordance with serum data, IL-17F expression was also found higher in HCV-associated HCC tissues compared with NBNC HCC tissues at both the mRNA and protein levels. Conclusions: Our data suggest that IL-17F might be used as a valuable biological marker than IL-17A during chronic fibrosis progression and HCC development in HCV patients.
Date:	2017-07
Relation:	Infectious Agents and Cancer. 2017 Jul;12:Article number 42.
Link to:	http://dx.doi.org/10.1186/s13027-017-0152-7
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1750-9378&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000406552000001
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85026289169
Appears in Collections:	[Guann-Yi Yu] Periodical Articles [Fan-Chen Tseng] Periodical Articles

Files in This Item:

File	Description	Size	Format
ISI000406552000001.pdf		2458Kb	Adobe PDF	351	View/Open

Loading...