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| Title: | Functional mri imaging signatures in young men with prenatal exposure to dioxin-like chemicals |
| Authors: | Guo, L;Chu, CP;Huang, YC;Hsieh, ST |
| Contributors: | National Institute of Environmental Health Sciences |
| Abstract: | Introduction: In 1979, an episode of food intoxication by rice oil contaminated with dioxin-like chemicals occurred in Taiwan called Yucheng (oil-syndrome in Chinese). The children born to exposed women suffered from skin manifestations, tooth problems, reduced neurocognitive capability, etc. We aim to determine whether children born to Yucheng mothers had changes in functional MRI imaging signatures. Methods: The fMRI study was performed using a 3T MRI scanner. Gradient-echo echo-planar imaging (EPI) was used to acquire BOLD signal. Two different paradigms for fMRI, N-back task and picture rotation task, were used to simulate coding and object assembly subtest. All data were processed using SPM8(www.fil.ion.ucl.ac.uk/spm) implemented on MATLAB. Results: We recruited 10 men born to Yucheng mothers and 11 community controls, with mean age of 29 years. The Yucheng and control groups were similar in age, percentage of smoking and alcohol drinking, and years of education. The accuracy and response time of the N-back test and the picture rotation task between these two groups were similar. In the paradigm of the N-back test, the Yucheng men had increased BOLD signal in bilateral cingulate gyrus, dorsal medial prefrontal gyrus and inferior occipital gyrus. For the picture rotation task, bilateral parietal cortex, occipital cortex and dorsolateral prefrontal cortex were activated in the picture rotation task, while the medial frontal cortex, bilateral subcortical nuclei and right temporal lobe were deactivated. Yucheng men showed reduced activation over the anterior cingulate gyrus, right inferior frontal gyrus and medial temporal lobe in the picture rotation task. In the two-back task, Yucheng men had stronger activations over the dorsal medial prefrontal cortex and cingulate gyrus. Furthermore, these areas showed significant deactivations during the execution of the tasks. These results implied different image signatures between the two groups, less deactivations in the Yucheng subjects during the task. Similarly, the activation difference between the Yucheng men and their controls in picture rotation task could be attributed to stronger deactivations in the Yucheng descendants in the anterior cingulate gyrus, right medial temporal lobe and inferior frontal gyrus. Default mode network (DMN) on resting fMRI was obtained using the posterior cingulated cortex (PCC) as a seed, the PCC in the Yucheng group had increased connectivity with bilateral caudate nuclei, the right thalamus and left parahippocampal gyrus but decreased connectivity with the precuneous, right medial temporal gyrus and left superior temporal gyrus. Conclusion: Yucheng men prenatally exposed to dioxin-like chemicals had reduced DMN deactivation nodes, as well as alterations in task-induced deactivations, implying that different brain networks were used for the Yucheng group to achieve similar levels of neurocognitve functions. Further follow-up of neurocognitive functioning is warranted due to potential of mental decline found to associate with the current fMRI findings. |
| Date: | 2017-07-05 |
| Relation: | Brain Injury. 2017 Jul 5;31(6-7):845. |
| Link to: | http://dx.doi.org/10.1080/02699052.2017.1312145 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0269-9052&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000406734000259 |
| Appears in Collections: | [郭育良] 會議論文/會議摘要
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| ISI000406734000259.pdf | | 53Kb | Adobe PDF | 697 | View/Open |
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