國家衛生研究院 NHRI:Item 3990099045/10713
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    题名: Investigating the association between alcohol and risk of head and neck cancer in Taiwan
    作者: Huang, CC;Hsiao, JR;Lee, WT;Lee, YC;Ou, CY;Chang, CC;Lu, YC;Huang, JS;Wong, TY;Chen, KC;Tsai, ST;Fang, SY;Wu, JL;Wu, YH;Hsueh, WT;Yen, CJ;Wu, SY;Chang, JY;Lin, CL;Wang, YH;Weng, YL;Yang, HC;Chen, YS;Chang, JS
    贡献者: National Institute of Cancer Research
    摘要: Although alcohol is an established risk factor of head and neck cancer (HNC), insufficiencies exist in the literature in several aspects. We analyzed detailed alcohol consumption data (amount and type of alcoholic beverage) of 811 HNC patients and 940 controls to evaluate the association between alcohol and HNC by HNC sites and by genotypes of ADH1B and ALDH2. Alcohol was associated with an increased HNC risk in a dose-response relationship, with the highest risk observed for hypopharyngeal cancer, followed by oropharyngeal and laryngeal cancers. Liquor showed a stronger positive association with HNC than beer and wine. The highest HNC risk occurred in individuals with the slow ADH1B and slow/non-functional ALDH2 genotype combination. In our study population, 21.8% of HNCs, 55.7% of oropharyngeal cancers, and 89.1% of hypopharyngeal cancers could be attributed to alcohol. Alcohol accounted for 47.3% of HNCs among individuals with the slow ADH1B and slow/non-functional ALDH2 genotype combination. The HNC risk associated with alcohol became comparable to that of never/occasional drinkers after ten or more years of cessation from regular alcohol drinking. In conclusion, alcohol use is associated with an increased HNC risk, particularly for individuals with slow ethanol metabolism. HNC incidence may be reduced by alcohol cessation.
    日期: 2017-08-29
    關聯: Scientific Reports. 2017 Aug 29;7:Article number 9701.
    Link to: http://dx.doi.org/10.1038/s41598-017-08802-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000408536200007
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85028473115
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